The Link Between Atrial Fibrillation and Dementia

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INDUSTRY HIGHLIGHT ATRIAL FIBRILLATION About This Content
News and Information for Healthcare Professionals	August 20, 2012
Atrial Fibrillation and Dementia: An Association Beyond Stroke? As our nation ages, the prevalence of both atrial fibrillation (AF) and dementia are rising. Ten percent of the nearly 3 million people in the US affected by AF are over the age of 80.1 Conventionally, it's been easy to appreciate a pathway from AF to dementia involving clinically significant strokes damaging areas of the brain responsible for cognition. However, recent studies have suggested that AF itself is a risk factor for dementia even in the absence of clinical stroke.2-6 One meta-analysis of seven prospective trials found an odds ratio of 1.6 for the association between AF and dementia. Many of the individual studies had important methodologic limitations,7 however, such as small sample size leading to underpowering, short follow-up, unadjudicated identification of dementia, and AF diagnoses established only at baseline. Find out more about the link between AF and stroke. Read the full article at MedPageToday.com 1 Naccarelli GV, et al. Increasing Prevalence of Atrial Fibrillation and Flutter in the United States. Am J Cardiol. 2009;104:1534-1539. 2 Ott A, et al. Atrial Fibrillation and Dementia in a Population-Based Study. The Rotterdam Study. Stroke. 1997;28:316-321. 3 Kilander L, et al. Atrial Fibrillation is an Independent Determinant of Low Cognitive Function: A Cross-Sectional Study in Elderly Men. Stroke. 1998;29:1816-1820. 4 Bunch TJ, et al. Atrial Fibrillation is Independently Associated With Senile, Vascular, and Alzheimer's Dementia. Heart Rhythm. 2010;7:433-437. 5 Forti P, et al. Atrial Fibrillation and Risk of Dementia in Non-Demented Elderly Subjects With and Without Mild Cognitive Impairment. Neurol Res. 2006;28:625-629. 6 Tilvis RS, et al. Predictors of Cognitive Decline and Mortality of Aged People Over a 10-Year Period. J Gerontol A Biol Sci Med Sci. 2004;59:268-274. 7 Kwok CS, et al. Atrial Fibrillation and Incidence of Dementia: A Systematic Review and Meta-Analysis. Neurology. 2011;76:914-922.

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