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** ALCOHOL / ADDICTION / ILLEGAL DRUGS News **
Marijuana Use May Raise Nicotine Dependence
http://mnt.to/a/4cnT
People who have used marijuana may be more susceptible to the addictive properties of nicotine, researchers from the National Institute on Drug Abuse reported in the journal Neuropsychopharmacology.
In Pathological Gambling, Problems Differ With Age
http://mnt.to/a/4cmN
To successfully treat pathological gambling, you need to intervene at an early stage, according to Susana Jimenez-Murcia from the University Hospital of Bellvitge in Spain and colleagues. Their study shows that a patient's age influences how severe the psychopathology and clinical aspects of pathological gambling are.
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** ALLERGY News **
Risk-Mitigating Behaviors For People With Peanut/Tree Nut Allergies To Minimize Risk Of Reactions On Airplane Flights
http://mnt.to/a/4cn8
Few situations can provoke more anxiety for people with peanut or tree-nut allergies than having an allergic reaction while flying on an airplane and being unable to get help.But in a new study, published in the Journal of Allergy and Clinical Immunology-In Practice, researchers found passengers who engaged in eight mitigating factors were less likely to report an allergic reaction.
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** ALZHEIMER'S / DEMENTIA News **
Single Mutations In VCP Gene Implicated In A Number Of Neurodegenerative Diseases
http://mnt.to/a/4cmX
New research, published in Neuron, gives insight into how single mutations in the VCP gene cause a range of neurological conditions including a form of dementia called Inclusion Body Myopathy, Paget's Disease of the Bone and Frontotemporal Dementia (IBMPFD), and the motor neuron disease Amyotrophic Lateral Sclerosis (ALS).
Enhanced Electronic Medical Record Aging Brain Care Software Unveiled
http://mnt.to/a/4cmJ
Innovative medical records software developed by geriatricians and informaticians from the Regenstrief Institute and the Indiana University Center for Aging Research will provide more personalized health care for older adult patients, a population at significant risk for mental health decline and disorders.
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** ARTHRITIS / RHEUMATOLOGY News **
Lifestyle Factors Linked To Rheumatoid Arthritis
http://mnt.to/a/4cpk
Several lifestyle factors and pre-existing conditions are linked to an increased risk of developing rheumatoid arthritis.The finding came from a new study by researchers at the Arthritis Research UK Epidemiology Center, which is part of the National Institute of Health Research, Manchester Musculoskeletal Biomedical Research Unit, England, and was published in Annals of the Rheumatic Diseases.
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** AUTISM News **
Study Opens Promising New Direction In Autism Research
http://mnt.to/a/4cn6
Autism Speaks, the world's leading autism science and advocacy organization, has announced a study supported by one of Autism Speaks' first Suzanne and Bob Wright Trailblazer Awards, presents a new theory that autism may result from chronic danger signaling by mitochondria, cell structures that supply our cells with energy.
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** BIO-TERRORISM / TERRORISM News **
News From The Journal MBio®, Volume 4, Issue 1
http://mnt.to/a/4cmF
1 Disarming One of the Deadliest PathogensFrancisella tularensis, the cause of tularemia and one of the deadliest respiratory pathogens in existence, is considered a potential biological weapon because it is readily aerosolized and exhibits a high degree of infectivity and lethality in humans.
----------------------------------------------
** BIOLOGY / BIOCHEMISTRY News **
Getting White Fat Cells To Burn Calories Could Be Way To Tackle Obesity
http://mnt.to/a/4cpn
US scientists have discovered a protein switch that decides whether precursor fat cells turn into white fat cells that store calories, or brown fat cells that burn calories. They suggest the fight against obesity and diabetes could learn some valuable clues from studying how this switch works.
----------------------------------------------
** BIRD FLU / AVIAN FLU News **
Technique To Predict Hotspots For Future Flu Outbreaks
http://mnt.to/a/4cn7
This year's unusually long and rocky flu season would be nothing compared to the pandemic that could occur if bird flu became highly contagious among humans, which is why UCLA researchers and their colleagues are creating new ways to predict where an outbreak could emerge.
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** BLOOD / HEMATOLOGY News **
For Children With Hurler's Syndrome, Cord Blood Effective Alternative To Matched Donor Stem Cells
http://mnt.to/a/4cmV
Transplants of blood-forming stem cells from umbilical cord blood may be an effective alternative to transplants of matched donor bone marrow stem cells to treat children with a rare, debilitating disease known as Hurler's syndrome (HS), according to results of a study published online in Blood, the Journal of the American Society of Hematology (ASH).
Key Step In The Manufacture Of Red Blood Cells Decoded
http://mnt.to/a/4cmB
A healthy adult must generate as many as one hundred billion new red blood cells each day, to maintain the numbers circulating in his blood. A team of EPFL researchers has identified a key step in the process by which red blood cells are born.
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** BREAST CANCER News **
Mammograms Every Other Year Fine For Women Over 50
http://mnt.to/a/4cpj
Women aged 50 to 74 years who get mammograms every other year instead of every year are at a lower risk of false-positive results and at a similar risk of advanced-stage disease. The study, which was published in JAMA Internal Medicine, identified the outcomes of screening mammography for age, breast density and postmenopausal use of hormone therapy.
Blood Test Tracks Response To Cancer Treatment
http://mnt.to/a/4cnY
A blood test that tracks fragments of DNA shed by dying tumor cells could one day be used to monitor how well patients are responding to cancer treatment, according to a small study in women with advanced breast cancer.
Breast Cancer Patients Should Avoid High-Fat Dairy Products
http://mnt.to/a/4cnS
Patients who have suffered from breast cancer should avoid consuming high-fat dairy products in order to improve their long-term survival. The study, carried out by Kaiser Permanente researchers and published in the Journal of the National Cancer Institute, is one of the first of its kind to identify a link between high fat dairy consumption and poorer breast cancer survival.
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** CANCER / ONCOLOGY News **
Blood Test Tracks Response To Cancer Treatment
http://mnt.to/a/4cnY
A blood test that tracks fragments of DNA shed by dying tumor cells could one day be used to monitor how well patients are responding to cancer treatment, according to a small study in women with advanced breast cancer.
Breast Cancer Patients Should Avoid High-Fat Dairy Products
http://mnt.to/a/4cnS
Patients who have suffered from breast cancer should avoid consuming high-fat dairy products in order to improve their long-term survival. The study, carried out by Kaiser Permanente researchers and published in the Journal of the National Cancer Institute, is one of the first of its kind to identify a link between high fat dairy consumption and poorer breast cancer survival.
Kinase Inhibitors Could Keep Cancer Patients Alive For Much Longer
http://mnt.to/a/4cnR
Kinase inhibitors, a class of cutting-edge cancer medications, could keep patients alive for far longer than is currently possible after scientists from the University of Sussex and The Institute of Cancer Research, England, discovered how they attack tumors.
Childhood Cancer And Survivor Fertility
http://mnt.to/a/4cnC
As success rates in treating childhood cancers have improved, greater emphasis is being placed on quality of life issues following successful treatment. Many cancer treatments can lead to infertility, but there are few methods to preserve the fertility of children who have not entered puberty.
How Vitamin E Can Help Prevent Cancer
http://mnt.to/a/4cn3
Researchers have identified an elusive anti-cancer property of vitamin E that has long been presumed to exist, but difficult to find.Many animal studies have suggested that vitamin E could prevent cancer, but human clinical trials following up on those findings have not shown the same benefits.
Promising New Cancer Diagnostic Technique
http://mnt.to/a/4cmx
Cancer cells break down sugars and produce the metabolic acid lactate at a much higher rate than normal cells. This phenomenon provides a telltale sign that cancer is present, via diagnostics such as PET scans, and possibly offers an avenue for novel cancer therapies.
Link Between Smoking And Worse Urothelial Cancer Prognosis, Especially For Women
http://mnt.to/a/4cmw
Smoking significantly increases individuals' risk of developing serious forms of urothelial carcinoma and a higher likelihood of dying from the disease, particularly for women. That is the conclusion of a recent study published in BJU International.
Terahertz Pulses That Destroy Skin Tissue, Increase Tumor-Suppressing Proteins At The Same Time
http://mnt.to/a/4cmv
Terahertz (THz) radiation, a slice of the electromagnetic spectrum that occupies the middle ground between microwaves and infrared light, is rapidly finding important uses in medical diagnostics, security, and scientific research.
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** CARDIOVASCULAR / CARDIOLOGY News **
Blood Protein Able To Detect Higher Risk Of Cardiovascular Events In People With Chest Pain Originating From Heart Disease
http://mnt.to/a/4cpc
Higher levels of pregnancy-associated plasma protein A (PAPP-A) were associated with an increased risk of cardiovascular events in people with cardiac chest pain that developed as a result of heart disease/coronary artery disease, according to a study published in CMAJ (Canadian Medical Association Journal).
Brain Aneurysm Treatment Used To Stop Irregular Heart Rhythms
http://mnt.to/a/4cmD
For the first time, a UCLA team has used a technique normally employed in treating brain aneurysms to treat severe, life-threatening irregular heart rhythms in two patients.This unique use of the method helped stop ventricular arrhythmias - which cause "electrical storms" - that originated in the septum, the thick muscle that separates the heart's two ventricles.
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** CERVICAL CANCER / HPV VACCINE News **
Fears of Parents Prevent Girls From Getting HPV Vaccine
http://mnt.to/a/4cpm
Health professionals strongly recommend the vaccine for the human papilloma virus (HPV) - the virus that causes most cases of cervical cancer - for women and girls. However, many parents are worried about its safety, a new study in Pediatrics suggests.
Staggeringly Low Uptake Of HPV Vaccine Points To Failures In Patient Education, Vaccine Programs
http://mnt.to/a/4cmP
Completion rates for the human papillomavirus (HPV) vaccine series across both genders continue to remain alarmingly low nearly seven years after its introduction, suggesting that better patient education and increased public vaccine financing programs are needed, according to new research from the University of Texas Medical Branch (UTMB).
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** CONFERENCES News **
Learn Best Practices From Your Peers At The Gross-To-Net Accounting Forum, 17-18 June 2013, Boston, MA
http://mnt.to/a/4cph
Ensuring your Gross-to-Net calculations are accurate is a messy business, but a necessary one. In the GTN space, the pharmaceutical industry has just recently begun to open up about forecasting and accruing for liability or working interdepartmentally between the commercial and government sectors.
NICE Turnaround On Novartis' Xolair To Be Discussed At Asthma & Copd Conference, 15-16 April 2013, London
http://mnt.to/a/4cnZ
The UK's National Institute for Health and Clinical Excellence (NICE) has recently recommended Xolair, Novartis as an option for treating severe, persistent allergic asthma in adults, adolescents and children.
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** DEPRESSION News **
Childhood Depression Linked To Cardiac Risks Later In Life
http://mnt.to/a/4cnB
Teens who were depressed as children are far more likely than their peers to be obese, smoke cigarettes and lead sedentary lives, even if they no longer suffer from depression.The research, by scientists at Washington University School of Medicine in St.
In Pathological Gambling, Problems Differ With Age
http://mnt.to/a/4cmN
To successfully treat pathological gambling, you need to intervene at an early stage, according to Susana Jimenez-Murcia from the University Hospital of Bellvitge in Spain and colleagues. Their study shows that a patient's age influences how severe the psychopathology and clinical aspects of pathological gambling are.
----------------------------------------------
** DERMATOLOGY News **
Cytoskeletal Dysregulation Underlies Buruli Ulcer Formation
http://mnt.to/a/4cnD
Mycobacterium ulcerans infects the skin and subcutaneous tissues and secretes a lipid toxin, mycolactone, which causes open skin lesions, known as Buruli ulcers. In this issue of the Journal of Clinical Investigation, researchers led by Caroline Demangel at the Pasteur Institue in Paris investigated the molecular actions of mycolactone and found that it dysregulates the cellular skeleton (cytoskeleton) through activation of a protein known as N-WASP.
----------------------------------------------
** DIABETES News **
Learning How Brown Fat Cells Develop Offers Hope In The Fight Against Obesity
http://mnt.to/a/4cmy
Brown fat is a hot topic, pardon the pun. Brown fats cells, as opposed to white fat cells, make heat for the body, and are thought to have evolved to help mammals cope with the cold. But, their role in generating warmth might also be applied to coping with obesity and diabetes.
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** DYSLEXIA News **
Overcoming Reading Problems: How Can We Stlil Raed Words Wehn Teh Lettres Are Jmbuled Up?
http://mnt.to/a/4cmZ
Researchers in the UK have taken an important step towards understanding how the human brain 'decodes' letters on a page to read a word. The work, funded by the Economic and Social Research Council (ESRC), will help psychologists unravel the subtle thinking mechanisms involved in reading, and could provide solutions for helping people who find it difficult to read, for example in conditions such as dyslexia.
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** ENDOCRINOLOGY News **
Oral Estrogen Hormone Therapy Linked To Increased Risk Of Gallbladder Surgery In Menopausal Women
http://mnt.to/a/4cpb
Oral estrogen therapy for menopausal women is associated with an increased risk of gallbladder surgery, according to a large-scale study of more than 70 000 women in France published in CMAJ (Canadian Medical Association Journal).
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** ERECTILE DYSFUNCTION / PREMATURE EJACULATION News **
Novel Therapeutic Strategy For Erectile Dysfunction
http://mnt.to/a/4cnd
Transplantation of mesenchymal stem cells cultivated on the surface of nanofibrous meshes could be a novel therapeutic strategy against post-prostatectomy erectile dysfunction (ED), conclude the authors of a study which is to be presented at the 28th Annual EAU Congress later this week.
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** FERTILITY News **
Childhood Cancer And Survivor Fertility
http://mnt.to/a/4cnC
As success rates in treating childhood cancers have improved, greater emphasis is being placed on quality of life issues following successful treatment. Many cancer treatments can lead to infertility, but there are few methods to preserve the fertility of children who have not entered puberty.
----------------------------------------------
** FLU / COLD / SARS News **
Technique To Predict Hotspots For Future Flu Outbreaks
http://mnt.to/a/4cn7
This year's unusually long and rocky flu season would be nothing compared to the pandemic that could occur if bird flu became highly contagious among humans, which is why UCLA researchers and their colleagues are creating new ways to predict where an outbreak could emerge.
Enlisting Two Suboptimal Vaccine Approaches Could Lead To A Universal Shot Against The Flu
http://mnt.to/a/4cmz
Seasonal epidemics of influenza result in nearly 36,000 deaths annually in the United States, according to the Centers for Disease Control. Current vaccines against the influenza virus elicit an antibody response specific for proteins on the outside of the virus, specifically the hemagglutinin (HA) protein.
----------------------------------------------
** GENETICS News **
Getting White Fat Cells To Burn Calories Could Be Way To Tackle Obesity
http://mnt.to/a/4cpn
US scientists have discovered a protein switch that decides whether precursor fat cells turn into white fat cells that store calories, or brown fat cells that burn calories. They suggest the fight against obesity and diabetes could learn some valuable clues from studying how this switch works.
Single Mutations In VCP Gene Implicated In A Number Of Neurodegenerative Diseases
http://mnt.to/a/4cmX
New research, published in Neuron, gives insight into how single mutations in the VCP gene cause a range of neurological conditions including a form of dementia called Inclusion Body Myopathy, Paget's Disease of the Bone and Frontotemporal Dementia (IBMPFD), and the motor neuron disease Amyotrophic Lateral Sclerosis (ALS).
Herpes Simplex Virus Vector Offers Novel Treatment Approach For Bladder Pain
http://mnt.to/a/4cmK
Severe chronic pain associated with conditions such as bladder pain syndrome/interstitial cystitis often require the use of opioid medication, with the risk of dependency and serious adverse reactions.
New Sensor Developed For Methylated DNA
http://mnt.to/a/4cmH
Collaborators from Mayo-Illinois Alliance for Technology Based Healthcare have developed a new, single molecule test for detecting methylated DNA. Methylation -- the addition of a methyl group of molecules to a DNA strand -- is one of the ways gene expression is regulated.
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** HEART DISEASE News **
Blood Protein Able To Detect Higher Risk Of Cardiovascular Events In People With Chest Pain Originating From Heart Disease
http://mnt.to/a/4cpc
Higher levels of pregnancy-associated plasma protein A (PAPP-A) were associated with an increased risk of cardiovascular events in people with cardiac chest pain that developed as a result of heart disease/coronary artery disease, according to a study published in CMAJ (Canadian Medical Association Journal).
Childhood Depression Linked To Cardiac Risks Later In Life
http://mnt.to/a/4cnB
Teens who were depressed as children are far more likely than their peers to be obese, smoke cigarettes and lead sedentary lives, even if they no longer suffer from depression.The research, by scientists at Washington University School of Medicine in St.
----------------------------------------------
** HUNTINGTONS DISEASE News **
New Structural Insight Into Neurodegenerative Disease
http://mnt.to/a/4cmY
A research team from the Korea Advanced Institute of Science and Technology (KAIST) released their results on the structure and molecular details of the neurodegenerative disease-associated protein Ataxin-1.
----------------------------------------------
** IMMUNE SYSTEM / VACCINES News **
Fears of Parents Prevent Girls From Getting HPV Vaccine
http://mnt.to/a/4cpm
Health professionals strongly recommend the vaccine for the human papilloma virus (HPV) - the virus that causes most cases of cervical cancer - for women and girls. However, many parents are worried about its safety, a new study in Pediatrics suggests.
Potential Of Combined Vaccine And Steroid Drug In Castration Resistant PCa Shown By Japanese P2 Study
http://mnt.to/a/4cnc
Multi-peptide vaccination therapy combined with the low-dose steroid drug dexamethasone shows promise in treating chemotherapy-naive castration resistant prostate cancer (CRPC) patients.The study, which won the third prize for best abstract in oncology at the 28th European Association of Urology Congress held in Milan, Italy from 15 to 19 March, showed the promising benefit of this combination therapy in patients who are chemotherapy-naive or those not yet exposed to specific antigens.
Flagellin May Be Key In Stimulating Body's Natural Defences Against Urinary Tract Infections
http://mnt.to/a/4cnb
A new study by British scientists reveals that motile Escherichia coli isolates demonstrated significant activation of NF-(Kappa)B signaling suggesting that flagellin plays a key role in up-regulating the host innate defences against urinary tract infections (UTIs).
A Step Closer To Explaining How Long-Term Infections Occur: Immune Finding Aids Quest For Vaccines To Beat Tropical Infections
http://mnt.to/a/4cmS
Scientists are a step closer to developing vaccines for a range of diseases that affect 200 million people, mainly in tropical south-east Asia, Africa and Central America.Researchers studying infections caused by parasitic worms - which can lead to diseases such as elephantiasis and river blindness - have shown how these can shut down a part of the immune system that might otherwise fight sickness.
Making Headway In Developing A Vaccine For The Leading Infectious Cause Of Congenital Birth Defects
http://mnt.to/a/4cmQ
A virus that most people have probably never heard of, yet most of us carry, is the number one infectious cause of congenital birth defects. One in 750 children are born with, or develop, permanent disabilities such as hearing loss or brain damage as a result of CMV (cytomegalovirus) infection in the womb.
Enlisting Two Suboptimal Vaccine Approaches Could Lead To A Universal Shot Against The Flu
http://mnt.to/a/4cmz
Seasonal epidemics of influenza result in nearly 36,000 deaths annually in the United States, according to the Centers for Disease Control. Current vaccines against the influenza virus elicit an antibody response specific for proteins on the outside of the virus, specifically the hemagglutinin (HA) protein.
----------------------------------------------
** INFECTIOUS DISEASES / BACTERIA / VIRUSES News **
Cytoskeletal Dysregulation Underlies Buruli Ulcer Formation
http://mnt.to/a/4cnD
Mycobacterium ulcerans infects the skin and subcutaneous tissues and secretes a lipid toxin, mycolactone, which causes open skin lesions, known as Buruli ulcers. In this issue of the Journal of Clinical Investigation, researchers led by Caroline Demangel at the Pasteur Institue in Paris investigated the molecular actions of mycolactone and found that it dysregulates the cellular skeleton (cytoskeleton) through activation of a protein known as N-WASP.
New Cells Found In The Urethra Which May Detect Hazardous Substances
http://mnt.to/a/4cnf
A recent study conducted by a group of German scientists revealed the presence of a previously unknown cell in the urethra of mice. These chemosensory cholinergic brush cells are in close contact to sensory neurons that express cholinergic receptors.
Flagellin May Be Key In Stimulating Body's Natural Defences Against Urinary Tract Infections
http://mnt.to/a/4cnb
A new study by British scientists reveals that motile Escherichia coli isolates demonstrated significant activation of NF-(Kappa)B signaling suggesting that flagellin plays a key role in up-regulating the host innate defences against urinary tract infections (UTIs).
Making Headway In Developing A Vaccine For The Leading Infectious Cause Of Congenital Birth Defects
http://mnt.to/a/4cmQ
A virus that most people have probably never heard of, yet most of us carry, is the number one infectious cause of congenital birth defects. One in 750 children are born with, or develop, permanent disabilities such as hearing loss or brain damage as a result of CMV (cytomegalovirus) infection in the womb.
Copper Detoxification Used As Crafty Defense Mechanism By The Fungus Cryptococcus neoformans
http://mnt.to/a/4cmG
A potentially lethal fungal infection appears to gain virulence by being able to anticipate and disarm a hostile immune attack in the lungs, according to findings by researchers at Duke Medicine.
News From The Journal MBio®, Volume 4, Issue 1
http://mnt.to/a/4cmF
1 Disarming One of the Deadliest PathogensFrancisella tularensis, the cause of tularemia and one of the deadliest respiratory pathogens in existence, is considered a potential biological weapon because it is readily aerosolized and exhibits a high degree of infectivity and lethality in humans.
----------------------------------------------
** IT / INTERNET / E-MAIL News **
Enhanced Electronic Medical Record Aging Brain Care Software Unveiled
http://mnt.to/a/4cmJ
Innovative medical records software developed by geriatricians and informaticians from the Regenstrief Institute and the Indiana University Center for Aging Research will provide more personalized health care for older adult patients, a population at significant risk for mental health decline and disorders.
----------------------------------------------
** MEDICAL DEVICES / DIAGNOSTICS News **
Blood Test Tracks Response To Cancer Treatment
http://mnt.to/a/4cnY
A blood test that tracks fragments of DNA shed by dying tumor cells could one day be used to monitor how well patients are responding to cancer treatment, according to a small study in women with advanced breast cancer.
Promising New Cancer Diagnostic Technique
http://mnt.to/a/4cmx
Cancer cells break down sugars and produce the metabolic acid lactate at a much higher rate than normal cells. This phenomenon provides a telltale sign that cancer is present, via diagnostics such as PET scans, and possibly offers an avenue for novel cancer therapies.
Terahertz Pulses That Destroy Skin Tissue, Increase Tumor-Suppressing Proteins At The Same Time
http://mnt.to/a/4cmv
Terahertz (THz) radiation, a slice of the electromagnetic spectrum that occupies the middle ground between microwaves and infrared light, is rapidly finding important uses in medical diagnostics, security, and scientific research.
----------------------------------------------
** MENOPAUSE News **
Oral Estrogen Hormone Therapy Linked To Increased Risk Of Gallbladder Surgery In Menopausal Women
http://mnt.to/a/4cpb
Oral estrogen therapy for menopausal women is associated with an increased risk of gallbladder surgery, according to a large-scale study of more than 70 000 women in France published in CMAJ (Canadian Medical Association Journal).
----------------------------------------------
** MUSCULAR DYSTROPHY / ALS News **
Single Mutations In VCP Gene Implicated In A Number Of Neurodegenerative Diseases
http://mnt.to/a/4cmX
New research, published in Neuron, gives insight into how single mutations in the VCP gene cause a range of neurological conditions including a form of dementia called Inclusion Body Myopathy, Paget's Disease of the Bone and Frontotemporal Dementia (IBMPFD), and the motor neuron disease Amyotrophic Lateral Sclerosis (ALS).
----------------------------------------------
** NEUROLOGY / NEUROSCIENCE News **
Suppressing The Brain's "Filter" Can Improve Performance In Creative Tasks
http://mnt.to/a/4cn5
The brain's prefrontal cortex is thought to be the seat of cognitive control, working as a kind of filter that keeps irrelevant thoughts, perceptions and memories from interfering with a task at hand.
New Structural Insight Into Neurodegenerative Disease
http://mnt.to/a/4cmY
A research team from the Korea Advanced Institute of Science and Technology (KAIST) released their results on the structure and molecular details of the neurodegenerative disease-associated protein Ataxin-1.
Insights Into Human Cognitive Development Provided By Pig Brain Models
http://mnt.to/a/4cmL
A mutual curiosity about patterns of growth and development in pig brains has brought two University of Illinois research groups together. Animal scientists Rod Johnson and Ryan Dilger have developed a model of the pig brain that they plan to use to answer important questions about human brain development.
Copper Detoxification Used As Crafty Defense Mechanism By The Fungus Cryptococcus neoformans
http://mnt.to/a/4cmG
A potentially lethal fungal infection appears to gain virulence by being able to anticipate and disarm a hostile immune attack in the lungs, according to findings by researchers at Duke Medicine.
Brain Aneurysm Treatment Used To Stop Irregular Heart Rhythms
http://mnt.to/a/4cmD
For the first time, a UCLA team has used a technique normally employed in treating brain aneurysms to treat severe, life-threatening irregular heart rhythms in two patients.This unique use of the method helped stop ventricular arrhythmias - which cause "electrical storms" - that originated in the septum, the thick muscle that separates the heart's two ventricles.
----------------------------------------------
** NUTRITION / DIET News **
Breast Cancer Patients Should Avoid High-Fat Dairy Products
http://mnt.to/a/4cnS
Patients who have suffered from breast cancer should avoid consuming high-fat dairy products in order to improve their long-term survival. The study, carried out by Kaiser Permanente researchers and published in the Journal of the National Cancer Institute, is one of the first of its kind to identify a link between high fat dairy consumption and poorer breast cancer survival.
How Vitamin E Can Help Prevent Cancer
http://mnt.to/a/4cn3
Researchers have identified an elusive anti-cancer property of vitamin E that has long been presumed to exist, but difficult to find.Many animal studies have suggested that vitamin E could prevent cancer, but human clinical trials following up on those findings have not shown the same benefits.
Oils And Fats Regulate Feeling Of Satiety, But Olive Oil Works Best
http://mnt.to/a/4cmR
Reduced-fat food products are gaining in popularity. More and more people are choosing "light" products in an attempt to lose weight, or at least in the hope that they will not gain any pounds.
Not Drinking Milk At College Age Increases Risk For Metabolic Syndrome
http://mnt.to/a/4cmC
College-age kids who don't consume at least three servings of dairy daily are three times more likely to develop metabolic syndrome than those who do, said a new University of Illinois study.
----------------------------------------------
** OBESITY / WEIGHT LOSS / FITNESS News **
Getting White Fat Cells To Burn Calories Could Be Way To Tackle Obesity
http://mnt.to/a/4cpn
US scientists have discovered a protein switch that decides whether precursor fat cells turn into white fat cells that store calories, or brown fat cells that burn calories. They suggest the fight against obesity and diabetes could learn some valuable clues from studying how this switch works.
Oils And Fats Regulate Feeling Of Satiety, But Olive Oil Works Best
http://mnt.to/a/4cmR
Reduced-fat food products are gaining in popularity. More and more people are choosing "light" products in an attempt to lose weight, or at least in the hope that they will not gain any pounds.
Not Drinking Milk At College Age Increases Risk For Metabolic Syndrome
http://mnt.to/a/4cmC
College-age kids who don't consume at least three servings of dairy daily are three times more likely to develop metabolic syndrome than those who do, said a new University of Illinois study.
Learning How Brown Fat Cells Develop Offers Hope In The Fight Against Obesity
http://mnt.to/a/4cmy
Brown fat is a hot topic, pardon the pun. Brown fats cells, as opposed to white fat cells, make heat for the body, and are thought to have evolved to help mammals cope with the cold. But, their role in generating warmth might also be applied to coping with obesity and diabetes.
----------------------------------------------
** PAIN / ANESTHETICS News **
Herpes Simplex Virus Vector Offers Novel Treatment Approach For Bladder Pain
http://mnt.to/a/4cmK
Severe chronic pain associated with conditions such as bladder pain syndrome/interstitial cystitis often require the use of opioid medication, with the risk of dependency and serious adverse reactions.
----------------------------------------------
** PARKINSON'S DISEASE News **
New Structural Insight Into Neurodegenerative Disease
http://mnt.to/a/4cmY
A research team from the Korea Advanced Institute of Science and Technology (KAIST) released their results on the structure and molecular details of the neurodegenerative disease-associated protein Ataxin-1.
----------------------------------------------
** PEDIATRICS / CHILDREN'S HEALTH News **
Childhood Cancer And Survivor Fertility
http://mnt.to/a/4cnC
As success rates in treating childhood cancers have improved, greater emphasis is being placed on quality of life issues following successful treatment. Many cancer treatments can lead to infertility, but there are few methods to preserve the fertility of children who have not entered puberty.
Childhood Depression Linked To Cardiac Risks Later In Life
http://mnt.to/a/4cnB
Teens who were depressed as children are far more likely than their peers to be obese, smoke cigarettes and lead sedentary lives, even if they no longer suffer from depression.The research, by scientists at Washington University School of Medicine in St.
For Children With Hurler's Syndrome, Cord Blood Effective Alternative To Matched Donor Stem Cells
http://mnt.to/a/4cmV
Transplants of blood-forming stem cells from umbilical cord blood may be an effective alternative to transplants of matched donor bone marrow stem cells to treat children with a rare, debilitating disease known as Hurler's syndrome (HS), according to results of a study published online in Blood, the Journal of the American Society of Hematology (ASH).
Risk Of Smoking Greater In Children Of Divorced Parents
http://mnt.to/a/4cmT
Both daughters and sons from divorced families are significantly more likely to initiate smoking in comparison to their peers from intact families, shows a new analysis of 19,000 Americans.This University of Toronto study, published online this month in the journal Public Health, shows that men who experienced parental divorce before they turned 18 had 48-per-cent higher odds of ever smoking 100 or more cigarettes than men whose parents did not divorce.
Teen Sexting: The Gender Gap And The Potential For Long-Term Harm
http://mnt.to/a/4cmM
Sexting: Involves sending sexually explicit messages and/or photographs, primarily between mobile phones using the SMS system was first reported in 2005. It is an obvious portmanteau of "sex" and "texting"; the word was added to the Merriam-Webster's Collegiate Dictionary in August 2012.
Not Drinking Milk At College Age Increases Risk For Metabolic Syndrome
http://mnt.to/a/4cmC
College-age kids who don't consume at least three servings of dairy daily are three times more likely to develop metabolic syndrome than those who do, said a new University of Illinois study.
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** PREGNANCY / OBSTETRICS News **
Preconception Health Trends Among Women Of Reproductive Age
http://mnt.to/a/4cmW
A woman's health status before pregnancy is critical for the health and wellbeing of the fetus and mother-to-be. The U.S. Centers for Disease Control and Prevention (CDC) has set Healthy People 2020 national objectives for women of reproductive age, and young women are making important gains toward achieving some of those health goals, while some trends are less encouraging, as reported in a study published in Journal of Women's Health, a peer-reviewed publication from Mary Ann Liebert, Inc.
Making Headway In Developing A Vaccine For The Leading Infectious Cause Of Congenital Birth Defects
http://mnt.to/a/4cmQ
A virus that most people have probably never heard of, yet most of us carry, is the number one infectious cause of congenital birth defects. One in 750 children are born with, or develop, permanent disabilities such as hearing loss or brain damage as a result of CMV (cytomegalovirus) infection in the womb.
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** PROSTATE / PROSTATE CANCER News **
In Castration Resistant Prostate Cancer, Study Shows Additional Role For Abiraterone In Blocking Tumor Growth
http://mnt.to/a/4cng
As part of an EU-supported IMI-PREDECT consortium, a Dutch study showed that anti-androgenic properties of the drug abiraterone may provide an additional mechanism of action in blocking tumour growth of castration resistant prostate cancer (CRPC).
Novel Therapeutic Strategy For Erectile Dysfunction
http://mnt.to/a/4cnd
Transplantation of mesenchymal stem cells cultivated on the surface of nanofibrous meshes could be a novel therapeutic strategy against post-prostatectomy erectile dysfunction (ED), conclude the authors of a study which is to be presented at the 28th Annual EAU Congress later this week.
Potential Of Combined Vaccine And Steroid Drug In Castration Resistant PCa Shown By Japanese P2 Study
http://mnt.to/a/4cnc
Multi-peptide vaccination therapy combined with the low-dose steroid drug dexamethasone shows promise in treating chemotherapy-naive castration resistant prostate cancer (CRPC) patients.The study, which won the third prize for best abstract in oncology at the 28th European Association of Urology Congress held in Milan, Italy from 15 to 19 March, showed the promising benefit of this combination therapy in patients who are chemotherapy-naive or those not yet exposed to specific antigens.
In Men With Localized PCa, Surgery Is Superior To Radiotherapy: Swedish Study
http://mnt.to/a/4cn9
Surgery offers better survival benefit for men with localised prostate cancer, according to a large observational study, conducted by a group of researchers in Sweden and the Netherlands.The study won the second prize for best abstract in oncology at the 28th Annual EAU Congress which opened in Milan 15 March.
How Vitamin E Can Help Prevent Cancer
http://mnt.to/a/4cn3
Researchers have identified an elusive anti-cancer property of vitamin E that has long been presumed to exist, but difficult to find.Many animal studies have suggested that vitamin E could prevent cancer, but human clinical trials following up on those findings have not shown the same benefits.
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** PSYCHOLOGY / PSYCHIATRY News **
Suppressing The Brain's "Filter" Can Improve Performance In Creative Tasks
http://mnt.to/a/4cn5
The brain's prefrontal cortex is thought to be the seat of cognitive control, working as a kind of filter that keeps irrelevant thoughts, perceptions and memories from interfering with a task at hand.
How Mindfulness Can Improve Self-Knowledge
http://mnt.to/a/4cn4
Mindfulness - paying attention to one's current experience in a non-judgmental way - might help us to learn more about our own personalities, according to a new article published in the March 2013 issue of Perspectives on Psychological Science, a journal of the Association for Psychological Science.
Overcoming Reading Problems: How Can We Stlil Raed Words Wehn Teh Lettres Are Jmbuled Up?
http://mnt.to/a/4cmZ
Researchers in the UK have taken an important step towards understanding how the human brain 'decodes' letters on a page to read a word. The work, funded by the Economic and Social Research Council (ESRC), will help psychologists unravel the subtle thinking mechanisms involved in reading, and could provide solutions for helping people who find it difficult to read, for example in conditions such as dyslexia.
Risk Of Smoking Greater In Children Of Divorced Parents
http://mnt.to/a/4cmT
Both daughters and sons from divorced families are significantly more likely to initiate smoking in comparison to their peers from intact families, shows a new analysis of 19,000 Americans.This University of Toronto study, published online this month in the journal Public Health, shows that men who experienced parental divorce before they turned 18 had 48-per-cent higher odds of ever smoking 100 or more cigarettes than men whose parents did not divorce.
In Pathological Gambling, Problems Differ With Age
http://mnt.to/a/4cmN
To successfully treat pathological gambling, you need to intervene at an early stage, according to Susana Jimenez-Murcia from the University Hospital of Bellvitge in Spain and colleagues. Their study shows that a patient's age influences how severe the psychopathology and clinical aspects of pathological gambling are.
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** PUBLIC HEALTH News **
Risk-Mitigating Behaviors For People With Peanut/Tree Nut Allergies To Minimize Risk Of Reactions On Airplane Flights
http://mnt.to/a/4cn8
Few situations can provoke more anxiety for people with peanut or tree-nut allergies than having an allergic reaction while flying on an airplane and being unable to get help.But in a new study, published in the Journal of Allergy and Clinical Immunology-In Practice, researchers found passengers who engaged in eight mitigating factors were less likely to report an allergic reaction.
Technique To Predict Hotspots For Future Flu Outbreaks
http://mnt.to/a/4cn7
This year's unusually long and rocky flu season would be nothing compared to the pandemic that could occur if bird flu became highly contagious among humans, which is why UCLA researchers and their colleagues are creating new ways to predict where an outbreak could emerge.
Preconception Health Trends Among Women Of Reproductive Age
http://mnt.to/a/4cmW
A woman's health status before pregnancy is critical for the health and wellbeing of the fetus and mother-to-be. The U.S. Centers for Disease Control and Prevention (CDC) has set Healthy People 2020 national objectives for women of reproductive age, and young women are making important gains toward achieving some of those health goals, while some trends are less encouraging, as reported in a study published in Journal of Women's Health, a peer-reviewed publication from Mary Ann Liebert, Inc.
Teen Sexting: The Gender Gap And The Potential For Long-Term Harm
http://mnt.to/a/4cmM
Sexting: Involves sending sexually explicit messages and/or photographs, primarily between mobile phones using the SMS system was first reported in 2005. It is an obvious portmanteau of "sex" and "texting"; the word was added to the Merriam-Webster's Collegiate Dictionary in August 2012.
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** RADIOLOGY / NUCLEAR MEDICINE News **
Mammograms Every Other Year Fine For Women Over 50
http://mnt.to/a/4cpj
Women aged 50 to 74 years who get mammograms every other year instead of every year are at a lower risk of false-positive results and at a similar risk of advanced-stage disease. The study, which was published in JAMA Internal Medicine, identified the outcomes of screening mammography for age, breast density and postmenopausal use of hormone therapy.
In Men With Localized PCa, Surgery Is Superior To Radiotherapy: Swedish Study
http://mnt.to/a/4cn9
Surgery offers better survival benefit for men with localised prostate cancer, according to a large observational study, conducted by a group of researchers in Sweden and the Netherlands.The study won the second prize for best abstract in oncology at the 28th Annual EAU Congress which opened in Milan 15 March.
Terahertz Pulses That Destroy Skin Tissue, Increase Tumor-Suppressing Proteins At The Same Time
http://mnt.to/a/4cmv
Terahertz (THz) radiation, a slice of the electromagnetic spectrum that occupies the middle ground between microwaves and infrared light, is rapidly finding important uses in medical diagnostics, security, and scientific research.
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** RESPIRATORY / ASTHMA News **
Copper Detoxification Used As Crafty Defense Mechanism By The Fungus Cryptococcus neoformans
http://mnt.to/a/4cmG
A potentially lethal fungal infection appears to gain virulence by being able to anticipate and disarm a hostile immune attack in the lungs, according to findings by researchers at Duke Medicine.
News From The Journal MBio®, Volume 4, Issue 1
http://mnt.to/a/4cmF
1 Disarming One of the Deadliest PathogensFrancisella tularensis, the cause of tularemia and one of the deadliest respiratory pathogens in existence, is considered a potential biological weapon because it is readily aerosolized and exhibits a high degree of infectivity and lethality in humans.
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** SENIORS / AGING News **
Enhanced Electronic Medical Record Aging Brain Care Software Unveiled
http://mnt.to/a/4cmJ
Innovative medical records software developed by geriatricians and informaticians from the Regenstrief Institute and the Indiana University Center for Aging Research will provide more personalized health care for older adult patients, a population at significant risk for mental health decline and disorders.
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** SEXUAL HEALTH / STDS News **
'Daughter Aversion' And Contraception Use In Nepal
http://mnt.to/a/4cn2
While poverty and under-education continue to dampen contraception use in Nepal, exacerbating the country's efforts to reduce maternal and child mortality rates, researchers say another, more surprising factor may be more intractable: Deeply held cultural preferences for sons over daughters.
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** SMOKING / QUIT SMOKING News **
Marijuana Use May Raise Nicotine Dependence
http://mnt.to/a/4cnT
People who have used marijuana may be more susceptible to the addictive properties of nicotine, researchers from the National Institute on Drug Abuse reported in the journal Neuropsychopharmacology.
Risk Of Smoking Greater In Children Of Divorced Parents
http://mnt.to/a/4cmT
Both daughters and sons from divorced families are significantly more likely to initiate smoking in comparison to their peers from intact families, shows a new analysis of 19,000 Americans.This University of Toronto study, published online this month in the journal Public Health, shows that men who experienced parental divorce before they turned 18 had 48-per-cent higher odds of ever smoking 100 or more cigarettes than men whose parents did not divorce.
Link Between Smoking And Worse Urothelial Cancer Prognosis, Especially For Women
http://mnt.to/a/4cmw
Smoking significantly increases individuals' risk of developing serious forms of urothelial carcinoma and a higher likelihood of dying from the disease, particularly for women. That is the conclusion of a recent study published in BJU International.
----------------------------------------------
** STEM CELL RESEARCH News **
Novel Therapeutic Strategy For Erectile Dysfunction
http://mnt.to/a/4cnd
Transplantation of mesenchymal stem cells cultivated on the surface of nanofibrous meshes could be a novel therapeutic strategy against post-prostatectomy erectile dysfunction (ED), conclude the authors of a study which is to be presented at the 28th Annual EAU Congress later this week.
----------------------------------------------
** TRANSPLANTS / ORGAN DONATIONS News **
For Children With Hurler's Syndrome, Cord Blood Effective Alternative To Matched Donor Stem Cells
http://mnt.to/a/4cmV
Transplants of blood-forming stem cells from umbilical cord blood may be an effective alternative to transplants of matched donor bone marrow stem cells to treat children with a rare, debilitating disease known as Hurler's syndrome (HS), according to results of a study published online in Blood, the Journal of the American Society of Hematology (ASH).
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** TROPICAL DISEASES News **
A Step Closer To Explaining How Long-Term Infections Occur: Immune Finding Aids Quest For Vaccines To Beat Tropical Infections
http://mnt.to/a/4cmS
Scientists are a step closer to developing vaccines for a range of diseases that affect 200 million people, mainly in tropical south-east Asia, Africa and Central America.Researchers studying infections caused by parasitic worms - which can lead to diseases such as elephantiasis and river blindness - have shown how these can shut down a part of the immune system that might otherwise fight sickness.
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** UROLOGY / NEPHROLOGY News **
New Cells Found In The Urethra Which May Detect Hazardous Substances
http://mnt.to/a/4cnf
A recent study conducted by a group of German scientists revealed the presence of a previously unknown cell in the urethra of mice. These chemosensory cholinergic brush cells are in close contact to sensory neurons that express cholinergic receptors.
Flagellin May Be Key In Stimulating Body's Natural Defences Against Urinary Tract Infections
http://mnt.to/a/4cnb
A new study by British scientists reveals that motile Escherichia coli isolates demonstrated significant activation of NF-(Kappa)B signaling suggesting that flagellin plays a key role in up-regulating the host innate defences against urinary tract infections (UTIs).
Herpes Simplex Virus Vector Offers Novel Treatment Approach For Bladder Pain
http://mnt.to/a/4cmK
Severe chronic pain associated with conditions such as bladder pain syndrome/interstitial cystitis often require the use of opioid medication, with the risk of dependency and serious adverse reactions.
Link Between Smoking And Worse Urothelial Cancer Prognosis, Especially For Women
http://mnt.to/a/4cmw
Smoking significantly increases individuals' risk of developing serious forms of urothelial carcinoma and a higher likelihood of dying from the disease, particularly for women. That is the conclusion of a recent study published in BJU International.
----------------------------------------------
** WOMEN'S HEALTH / GYNECOLOGY News **
Fears of Parents Prevent Girls From Getting HPV Vaccine
http://mnt.to/a/4cpm
Health professionals strongly recommend the vaccine for the human papilloma virus (HPV) - the virus that causes most cases of cervical cancer - for women and girls. However, many parents are worried about its safety, a new study in Pediatrics suggests.
'Daughter Aversion' And Contraception Use In Nepal
http://mnt.to/a/4cn2
While poverty and under-education continue to dampen contraception use in Nepal, exacerbating the country's efforts to reduce maternal and child mortality rates, researchers say another, more surprising factor may be more intractable: Deeply held cultural preferences for sons over daughters.
Preconception Health Trends Among Women Of Reproductive Age
http://mnt.to/a/4cmW
A woman's health status before pregnancy is critical for the health and wellbeing of the fetus and mother-to-be. The U.S. Centers for Disease Control and Prevention (CDC) has set Healthy People 2020 national objectives for women of reproductive age, and young women are making important gains toward achieving some of those health goals, while some trends are less encouraging, as reported in a study published in Journal of Women's Health, a peer-reviewed publication from Mary Ann Liebert, Inc.
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