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** ALCOHOL / ADDICTION / ILLEGAL DRUGS News **
'Old Sober' Helps With Hangovers
http://mnt.to/a/4cPR
One of the Crescent City's time-honored traditions - a steaming bowl of Yak-a-mein Soup, a.k.a., "Old Sober" - after a night of partying in the French Quarter actually does have a basis in scientific fact.
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** ALZHEIMER'S / DEMENTIA News **
Dementia Care Study Confirms Dramatic Reduction In Use Of Antipsychotics And A Range Of Drugs With Corresponding Improvement In Wellbeing
http://mnt.to/a/4cRc
A new study of residents in specialised dementia care homes has confirmed a reduction, averaging 48 per cent, in the requirement for antipsychotic medication, together with dramatic reductions in usage of a range of other medications and a corresponding improvement in the wellbeing of participants.
Next-Generation Rat Model Will Advance Alzheimer's Research
http://mnt.to/a/4cPQ
A new genetically engineered lab rat that has the full array of brain changes associated with Alzheimer's disease supports the idea that increases in a molecule called beta-amyloid in the brain causes the disease, according to a study, published in the Journal of Neuroscience.
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** ARTHRITIS / RHEUMATOLOGY News **
'Mobility Shoes' Take A Load Off For Knee Osteoarthritis Suffers
http://mnt.to/a/4cR6
New research suggests that patients with knee osteoarthritis (OA) who wear flat, flexible footwear (mobility shoes) had significant reduction in knee loading - the force placed upon the joint during daily activities.
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** BIO-TERRORISM / TERRORISM News **
For Bioterror Threats, Currently Approved Drugs Found Effective In Laboratory Mice
http://mnt.to/a/4cPh
In the most extensive screen of its kind, Texas Biomed scientists in San Antonio have demonstrated the feasibility of repurposing already-approved drugs for use against highly pathogenic bacteria and viruses.
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** BIOLOGY / BIOCHEMISTRY News **
Understanding How Oncogenes Affect The Body Clock May Help Create Better Cancer Treatments
http://mnt.to/a/4cPZ
The Myc oncogene can disrupt the 24-hour internal rhythm in cancer cells. Postdoctoral fellow Brian Altman, PhD, and graduate student Annie Hsieh, MD, both from the in the lab of Chi Van Dang, MD, PhD, director of the Abramson Cancer Center, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, presented their data in the "Metabolic Pathway Regulation in Cancer" session at the 2013 American Association for Cancer Research meeting, Washington, D.
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** BONES / ORTHOPEDICS News **
'Mobility Shoes' Take A Load Off For Knee Osteoarthritis Suffers
http://mnt.to/a/4cR6
New research suggests that patients with knee osteoarthritis (OA) who wear flat, flexible footwear (mobility shoes) had significant reduction in knee loading - the force placed upon the joint during daily activities.
In Pediatric Bone Cancer, K9 Osteosarcoma Samples Identify Drivers Of Metastasis
http://mnt.to/a/4cQ7
Human osteosarcoma samples are hard to come by, making the disease difficult to study. However, K9 bone cancer is genetically indistinguishable from the human form of the disease, and over 10,000 canine patients develop the disease every year.
Future Disability May Be Predicted By Posture
http://mnt.to/a/4cPk
The shape of an individual's spinal column may predict his or her risk for nursing home admission or need of home assistance in old age, according to a new article published online in the Journals of Gerontology Series A: Biological Sciences and Medical Sciences.
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** BREAST CANCER News **
Inhibiting Growth Of Triple-Negative Breast Cancer With Omega-3 Fatty Acids
http://mnt.to/a/4cQm
Researchers from Fox Chase Cancer Center have found that omega-3 fatty acids and their metabolite products slow or stop the proliferation, or growth in the number of cells, of triple-negative breast cancer cells more effectively than cells from luminal types of the disease.
During Pregnancy, Excess Estrogen Can Silence BRCA1 In Daughters, Increasing Breast Cancer Risk
http://mnt.to/a/4cQ2
Excess estrogen levels during pregnancy can disable, in their daughters, a powerful breast cancer tumor suppressor gene, say researchers at Georgetown Lombardi Comprehensive Cancer Center. They found the DNA repair gene BRCA1 to be silenced in one year-old girls exposed to a high hormonal fetal environment.
Heterogeneity Quantified In Early Stage Breast-Cancer, Which Ultimately Could Help Doctors To Eradicate It Before More Invasive Cancers Develop
http://mnt.to/a/4cPW
A variety of mutations may give rise to breast cancer, but scientists generally assume that it starts off with just a few. That's because later-stage breast cancers tend to have more mutations - they are more heterogeneous - than early stage cancers.
Critical Metabolic Alterations Identified In Triple-Negative Breast Cancer Cells
http://mnt.to/a/4cPV
Researchers at Fox Chase Cancer Center have identified a host of small molecules critical to metabolism in cells of triple-negative breast cancer - one of the least understood groups of breast cancer.
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** CANCER / ONCOLOGY News **
"Death With Dignity" Program Is Rarely Used
http://mnt.to/a/4cSP
Doctors, patients, and their families have been okay with a "Death with Dignity" physician-assisted suicide program that is available to patients with fatal cancer at a Seattle clinic, a study suggests.
FDA Step Closer To Approving Breast Cancer Drug "Palbociclib"
http://mnt.to/a/4cRp
The pharmaceutical giant Pfizer has just announced that their drug "Palbociclib", a selective inhibitor of cyclin dependent kinases (CDK) 4 and 6, has just received Breakthrough Therapy designation by the United States Food and Drug Administration (FDA) for breast cancer treatment.
Tool Could Help Discover New Compounds, Combinations; Quickly Identify Most Effective Gastrointestinal Stromal Tumor Treatments
http://mnt.to/a/4cQn
A new preclinical technology enables researchers to quickly determine if a particular treatment is effective against gastrointestinal stromal tumors (GISTs), providing a boost to animal research and possibly patient care, according to new findings presented by Fox Chase Cancer Center at the AACR Annual Meeting 2013.
Hereditary Neuropathy And Chemotherapy-Induced Peripheral Neuropathy May Share Genetic Roots In Some Patients
http://mnt.to/a/4cQh
Seemingly benign differences in genetic code from one person to the next could influence who develops side effects to chemotherapy, a Mayo Clinic study has found. The study identified gene variations that can predispose people to chemotherapy-induced peripheral neuropathy, a condition that is hard to predict and often debilitating enough to cause cancer patients to stop their treatment early.
Neuroblastomas Vulnerable To Novel Class Of Drugs May Be Identified By Genetic Biomarker
http://mnt.to/a/4cQ9
An irregularity within many neuroblastoma cells may indicate whether a neuroblastoma tumor, a difficult-to-treat, early childhood cancer, is vulnerable to a new class of anti-cancer drugs known as BET bromodomain inhibitors, Dana-Farber/Children's Hospital Cancer Center scientists reported at the annual meeting of the American Association for Cancer Research in Washington, April 6-10.
In Pediatric Bone Cancer, K9 Osteosarcoma Samples Identify Drivers Of Metastasis
http://mnt.to/a/4cQ7
Human osteosarcoma samples are hard to come by, making the disease difficult to study. However, K9 bone cancer is genetically indistinguishable from the human form of the disease, and over 10,000 canine patients develop the disease every year.
Promising Phase I Clinical Trial Of Rogosertib Leads To Multi-Institutional Phase II Trial
http://mnt.to/a/4cQ4
Results of a phase 1 clinical trial reported at the American Association for Cancer Research (AACR) annual conference show that orally administered Rigosertib is well tolerated in patients with advanced solid tumors.
Understanding How Oncogenes Affect The Body Clock May Help Create Better Cancer Treatments
http://mnt.to/a/4cPZ
The Myc oncogene can disrupt the 24-hour internal rhythm in cancer cells. Postdoctoral fellow Brian Altman, PhD, and graduate student Annie Hsieh, MD, both from the in the lab of Chi Van Dang, MD, PhD, director of the Abramson Cancer Center, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, presented their data in the "Metabolic Pathway Regulation in Cancer" session at the 2013 American Association for Cancer Research meeting, Washington, D.
A Promising Drug Can Help Prevent Head And Neck Cancers
http://mnt.to/a/4cPY
Head and neck cancers typically begin in squamous cells that line moist surfaces inside the mouth, nose and throat. Squamous cell carcinoma of the head and neck (HNSCC) is the sixth most common type of cancer in the United States, and it is sometimes preceded by the appearance of changes inside the oral cavity called precancerous lesions.
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** CARDIOVASCULAR / CARDIOLOGY News **
A New Way To Treat Heart Disease?
http://mnt.to/a/4cQf
Hardening of the arteries, or atherosclerosis, is the primary cause of heart disease. It is caused by calcium accumulation in the blood vessels, which leads to arteries becoming narrow and stiff, obstructing blood flow and leading to heart complications.
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** CAREGIVERS / HOMECARE News **
Dementia Care Study Confirms Dramatic Reduction In Use Of Antipsychotics And A Range Of Drugs With Corresponding Improvement In Wellbeing
http://mnt.to/a/4cRc
A new study of residents in specialised dementia care homes has confirmed a reduction, averaging 48 per cent, in the requirement for antipsychotic medication, together with dramatic reductions in usage of a range of other medications and a corresponding improvement in the wellbeing of participants.
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** CLINICAL TRIALS / DRUG TRIALS News **
FDA Step Closer To Approving Breast Cancer Drug "Palbociclib"
http://mnt.to/a/4cRp
The pharmaceutical giant Pfizer has just announced that their drug "Palbociclib", a selective inhibitor of cyclin dependent kinases (CDK) 4 and 6, has just received Breakthrough Therapy designation by the United States Food and Drug Administration (FDA) for breast cancer treatment.
New Protocol Design Approaches Will Improve Clinical Trial Performance And Efficiency, According To Tufts Center For The Study Of Drug Development
http://mnt.to/a/4cRd
Growing protocol complexity-responsible for longer clinical study times, greater difficulty in recruiting volunteers, and rising drug development costs-is spurring new approaches to optimizing protocol design, according to leaders from the research-based drug industry recently convened by the Tufts Center for the Study of Drug Development.
Promising Phase I Clinical Trial Of Rogosertib Leads To Multi-Institutional Phase II Trial
http://mnt.to/a/4cQ4
Results of a phase 1 clinical trial reported at the American Association for Cancer Research (AACR) annual conference show that orally administered Rigosertib is well tolerated in patients with advanced solid tumors.
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** COLORECTAL CANCER News **
Space Radiation Reduces Ability Of Intestinal Cells To Destroy Oncoprotein, May Increase Colorectal Cancer Risk
http://mnt.to/a/4cQ3
Two studies funded by NASA and presented at the AACR Annual Meeting 2013 help explain why space radiation may increase the risk of colorectal cancer in humans.The researchers, from Georgetown Lombardi Comprehensive Cancer Center, found that cosmic radiation impairs the ability of cells in the intestines of mice to eliminate oncogenic proteins, thus substantially increasing development of colorectal tumors.
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** DERMATOLOGY News **
Synthetic Materials Inspired By Bean Leaves May Be A Future Trap For Bedbugs
http://mnt.to/a/4cQc
Inspired by a traditional Balkan bedbug remedy, researchers have documented how microscopic hairs on kidney bean leaves effectively stab and trap the biting insects, according to findings published online in the Journal of the Royal Society Interface.
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** EAR, NOSE AND THROAT News **
A Promising Drug Can Help Prevent Head And Neck Cancers
http://mnt.to/a/4cPY
Head and neck cancers typically begin in squamous cells that line moist surfaces inside the mouth, nose and throat. Squamous cell carcinoma of the head and neck (HNSCC) is the sixth most common type of cancer in the United States, and it is sometimes preceded by the appearance of changes inside the oral cavity called precancerous lesions.
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** EATING DISORDERS News **
Compulsive Eating And Excessive Weight Gain Curbed By Removal Of Hypothalamic Hamartoma
http://mnt.to/a/4cQk
Neurosurgeons at the University of Texas-Houston and Children's Memorial Hermann Hospital (Houston, Texas) report on the success they achieved when they removed a hypothalamic hamartoma (HH) from a 10-year-old girl to combat hyperphagia (excessive appetite and compulsive overeating) and consequent unhealthy weight gain.
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** ECZEMA / PSORIASIS News **
Psoriasis Increases Risk Of High Blood Pressure
http://mnt.to/a/4cRm
The World Health Organization recently began raising awareness for the risks that come with high blood pressure, and with this they recommended that healthcare professionals routinely scan for the health condition in people with psoriasis, an action praised by the International Federation of Psoriasis Associations (IFPA).
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** ENDOCRINOLOGY News **
Obesity May Not Be A Symptom Of Polycystic Ovary Syndrome
http://mnt.to/a/4cPg
The relationship between obesity and polycystic ovary syndrome may be exaggerated, likely because the women who actively seek care for the condition tend to be heavier than those identified through screening of the general population, researchers report.
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** EYE HEALTH / BLINDNESS News **
Rates Of Childhood Squint Surgery Have Plummeted Over Past 50 Years
http://mnt.to/a/4cR2
But there's still inexplicable fivefold difference in rates across England, similar to wide discrepancies in tonsil removalRates of surgery to correct childhood squint in England have tumbled over the past 50 years, finds research published online in the British Journal of Ophthalmology.
Side Effect Of Retinal Detachment May Be Prevented By Ranibizumab
http://mnt.to/a/4cQd
Proliferative vitreoretinopathy (PVR), or the formation of scar tissue in the eye, is a serious, sight-threatening complication in people recovering from surgical repair of retinal detachment.
Combination Therapy Could Be Key In Treating Blindness
http://mnt.to/a/4cPx
Researchers have discovered that using two kinds of therapy in tandem may be a knockout combo against inherited disorders that cause blindness. While their study focused on man's best friend, the treatment could help restore vision in people, too.
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** GASTROINTESTINAL / GASTROENTEROLOGY News **
Tool Could Help Discover New Compounds, Combinations; Quickly Identify Most Effective Gastrointestinal Stromal Tumor Treatments
http://mnt.to/a/4cQn
A new preclinical technology enables researchers to quickly determine if a particular treatment is effective against gastrointestinal stromal tumors (GISTs), providing a boost to animal research and possibly patient care, according to new findings presented by Fox Chase Cancer Center at the AACR Annual Meeting 2013.
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** GENETICS News **
Inostics DNA Blood Test Provides A More Precise Picture Of Resistance Mutations Than Traditional Biopsies
http://mnt.to/a/4cR8
A study presented at the AACR Annual Meeting 2013 indicates that a DNA blood testusing Inostics' BEAMing Digital PCR can detect more mutations associated with secondarydrug resistance in GIST patients than testing conventional biopsies.
Shedding Light On A Gene Mutation That Causes Signs Of Premature Aging
http://mnt.to/a/4cR5
Research from Western University and Lawson Health Research Institute sheds new light on a gene called ATRX and its function in the brain and pituitary. Children born with ATRX syndrome have cognitive defects and developmental abnormalities.
Study Identifies A Protein That Helps Trigger Both Normal Fetal Growth And Cancer
http://mnt.to/a/4cQj
Two researchers at the National Institutes of Health discovered a new genetic link between the rapid growth of healthy fetuses and the uncontrolled cell division in cancer. The findings shed light on normal development and on the genetic underpinnings of common cancers.
Hereditary Neuropathy And Chemotherapy-Induced Peripheral Neuropathy May Share Genetic Roots In Some Patients
http://mnt.to/a/4cQh
Seemingly benign differences in genetic code from one person to the next could influence who develops side effects to chemotherapy, a Mayo Clinic study has found. The study identified gene variations that can predispose people to chemotherapy-induced peripheral neuropathy, a condition that is hard to predict and often debilitating enough to cause cancer patients to stop their treatment early.
During Pregnancy, Excess Estrogen Can Silence BRCA1 In Daughters, Increasing Breast Cancer Risk
http://mnt.to/a/4cQ2
Excess estrogen levels during pregnancy can disable, in their daughters, a powerful breast cancer tumor suppressor gene, say researchers at Georgetown Lombardi Comprehensive Cancer Center. They found the DNA repair gene BRCA1 to be silenced in one year-old girls exposed to a high hormonal fetal environment.
Combination Therapy Could Be Key In Treating Blindness
http://mnt.to/a/4cPx
Researchers have discovered that using two kinds of therapy in tandem may be a knockout combo against inherited disorders that cause blindness. While their study focused on man's best friend, the treatment could help restore vision in people, too.
Genetic Predisposition Could Lead To Laziness
http://mnt.to/a/4cPj
Studies show 97 percent of American adults get less than 30 minutes of exercise a day, which is the minimum recommended amount based on federal guidelines. New research from the University of Missouri suggests certain genetic traits may predispose people to being more or less motivated to exercise and remain active.
Shedding Light On A Gene Mutation That Causes Signs Of Premature Aging
http://mnt.to/a/4cPd
Research from Western University and Lawson Health Research Institute sheds new light on a gene called ATRX and its function in the brain and pituitary. Children born with ATRX syndrome have cognitive defects and developmental abnormalities.
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** HEART DISEASE News **
A New Way To Treat Heart Disease?
http://mnt.to/a/4cQf
Hardening of the arteries, or atherosclerosis, is the primary cause of heart disease. It is caused by calcium accumulation in the blood vessels, which leads to arteries becoming narrow and stiff, obstructing blood flow and leading to heart complications.
World Heart Federation Position Statement Published Online In Nature Reviews Cardiology
http://mnt.to/a/4cPt
.
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** HYPERTENSION News **
Psoriasis Increases Risk Of High Blood Pressure
http://mnt.to/a/4cRm
The World Health Organization recently began raising awareness for the risks that come with high blood pressure, and with this they recommended that healthcare professionals routinely scan for the health condition in people with psoriasis, an action praised by the International Federation of Psoriasis Associations (IFPA).
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** INFECTIOUS DISEASES / BACTERIA / VIRUSES News **
Shire Launches Report That Quantifies The Health, Psycho-Social And Economic Impact Of Rare Diseases
http://mnt.to/a/4cRb
New findings reveal the substantial burden of rare diseases due to lack of resources, financial challenges and emotional unrestShire plc (LSE: SHP, NASDAQ: SHPG) have launched a Rare Disease Impact Report, which uncovers the health, psycho-social, and economic impact of rare diseases on patient and medical communities in the United States (US) and United Kingdom (UK).
Atox Bio Publishes Data Demonstrating The Broad Therapeutic Effect Of Its Flagship Product In Treating "Flesh Eating Bacteria"
http://mnt.to/a/4cR9
Atox Bio announced new data in an animal model of necrotizing soft tissue infection (NSTI), commonly known as "flesh eating bacteria" demonstrating that administration of a single dose of AB103, given several hours after infection even without any antibiotics, increased survival in animals, and reduced tissue necrosis, inflammation and bacterial burden at the site of infection without compromising the immune response.
Rate Of Health Care-Acquired Infections In The ICU Reduced By Copper Surfaces
http://mnt.to/a/4cPC
Placement of copper objects in intensive care unit (ICU) hospital rooms reduced the number of healthcare-acquired infections (HAIs) in patients by more than half, according to a new study published in the May issue of Infection Control and Hospital Epidemiology, the journal of the Society for Healthcare Epidemiology of America, in a special topic issue focused on the role of the environment in infection prevention.
Hydrogen Peroxide Vapor Eradicates Multidrug-Resistant Organisms From Unopened Supplies
http://mnt.to/a/4cPB
In rooms of patients with multidrug-resistant organisms (MDROs), the outside of the packages containing sterile items can become contaminated. Unused medical supplies are often thrown away to prevent the items from becoming pathways for transmission of drug-resistant microbes, and in the process this leads to increased healthcare costs.
Disinfection Intervention Highlights Effective Method In Removing Antibiotic-Resistant Bug
http://mnt.to/a/4cPz
With rates and deaths associated with Clostridium difficile (C. difficile) at historically high levels, many hospitals have taken extra steps to reduce these infections. New research finds that a dedicated daily cleaning crew who adequately clean and disinfect rooms contaminated by C.
Study Finds Bird Virus Promising For Prostate Cancer Treatment
http://mnt.to/a/4cPs
A study at the Virginia-Maryland Regional College of Veterinary Medicine has identified a chicken-killing virus as a promising treatment for prostate cancer in humans.Researchers have discovered that a genetically engineered Newcastle disease virus, which harms chickens but not humans, kills prostate cancer cells of all kinds, including hormone-resistant cancer cells.
Plant Proteins Control Chronic Disease In Toxoplasma Infections
http://mnt.to/a/4cPr
A new discovery about the malaria-related parasite Toxoplasma gondii -- which can threaten babies, AIDS patients, the elderly and others with weakened immune function -- may help solve the mystery of how this single-celled parasite establishes life-long infections in people.
For Bioterror Threats, Currently Approved Drugs Found Effective In Laboratory Mice
http://mnt.to/a/4cPh
In the most extensive screen of its kind, Texas Biomed scientists in San Antonio have demonstrated the feasibility of repurposing already-approved drugs for use against highly pathogenic bacteria and viruses.
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** LIVER DISEASE / HEPATITIS News **
Hepatitis Research Aided By New Rodent Viruses
http://mnt.to/a/4cQb
Newly discovered mouse viruses could pave the way for future progress in hepatitis research, enabling scientists to study human disease and vaccines in the ultimate lab animal. In a study to be published in mBio®, the online open-access journal of the American Society for Microbiology, scientists describe their search for viruses related to the human hepatitis C virus (HCV) and human pegiviruses (HPgV) in frozen stocks of wild mice.
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** LUNG CANCER News **
Genes Related To The Regulation Of The Cell Cycle Are Associated With Poor Patient Outcomes In Lung And Bladder Cancers
http://mnt.to/a/4cQ8
Believe it or not, while researchers have explored which genes are mutated in each type of tobacco-associated cancer, until now no one had thought to look across these types for common genes that might predict patient outcomes.
Combination Of 2 Existing Drugs Appears Safe In Patients Who Have Not Responded To Previous Treatments For Resistant Lung Cancer
http://mnt.to/a/4cPX
A new chemotherapy regimen appears to produce minimal side effects in patients with lung cancer that has not responded to previous therapy, paving the way for additional research to determine if the new regimen also helps shrink tumors, according findings to be presented by Fox Chase Cancer Center researchers at the AACR Annual Meeting 2013.
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** MELANOMA / SKIN CANCER News **
New Target Plus New Drug Equals Death Of Melanoma Cells
http://mnt.to/a/4cQ5
Collaborative research presented by the University of Colorado Cancer Center, the University of North Carolina at Chapel Hill, Harvard Medical School and the University of Pittsburgh, at the American Association for Cancer Research (AACR) Annual Conference, shows that the protein receptor Mer is overexpressed in melanoma and that the investigational drug UNC1062 blocks Mer survival signaling in these cells, killing them.
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** MEN'S HEALTH News **
Helping Men To Become Stepdads
http://mnt.to/a/4cPm
As any stepdad can tell you, it's one thing to win a mom's heart and another to win over her children.Although one-third of American children live in a stepfamily during part of their childhood, little is known about the development of the relationship between stepfathers and stepchildren.
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** MRI / PET / ULTRASOUND News **
Brain Scan Offers First Objective Measure Of Pain
http://mnt.to/a/4cSQ
Using fMRI scans of the brain, US scientists have for the first time developed a method of "seeing" pain and suggest it may lead to reliable ways for doctors to quantify objectively how much pain patients are feeling.
----------------------------------------------
** MRSA / DRUG RESISTANCE News **
Inostics DNA Blood Test Provides A More Precise Picture Of Resistance Mutations Than Traditional Biopsies
http://mnt.to/a/4cR8
A study presented at the AACR Annual Meeting 2013 indicates that a DNA blood testusing Inostics' BEAMing Digital PCR can detect more mutations associated with secondarydrug resistance in GIST patients than testing conventional biopsies.
Hydrogen Peroxide Vapor Eradicates Multidrug-Resistant Organisms From Unopened Supplies
http://mnt.to/a/4cPB
In rooms of patients with multidrug-resistant organisms (MDROs), the outside of the packages containing sterile items can become contaminated. Unused medical supplies are often thrown away to prevent the items from becoming pathways for transmission of drug-resistant microbes, and in the process this leads to increased healthcare costs.
Disinfection Intervention Highlights Effective Method In Removing Antibiotic-Resistant Bug
http://mnt.to/a/4cPz
With rates and deaths associated with Clostridium difficile (C. difficile) at historically high levels, many hospitals have taken extra steps to reduce these infections. New research finds that a dedicated daily cleaning crew who adequately clean and disinfect rooms contaminated by C.
----------------------------------------------
** MUSCULAR DYSTROPHY / ALS News **
ALS Drug Effects Highlight Potassium Channel Role In Spinal Muscular Atrophy
http://mnt.to/a/4cQg
There is no specific drug to treat spinal muscular atrophy (SMA), a family of motor neuron diseases that in its most severe form is the leading genetic cause of infant death in the United States and affects one in 6,000 people overall.
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** NEUROLOGY / NEUROSCIENCE News **
Brain Scan Offers First Objective Measure Of Pain
http://mnt.to/a/4cSQ
Using fMRI scans of the brain, US scientists have for the first time developed a method of "seeing" pain and suggest it may lead to reliable ways for doctors to quantify objectively how much pain patients are feeling.
Non-Amputees Experience Phantom Limb Sensation
http://mnt.to/a/4cSN
Non-amputated individuals can actually experience the illusion of having a phantom hand, according to a new study in the Journal of Cognitive Neuroscience.The research was conducted by neuroscientists at the Karolinska Institutet in Sweden who explained that the sensation of having a physical body is not as obvious as some people may assume.
Compulsive Eating And Excessive Weight Gain Curbed By Removal Of Hypothalamic Hamartoma
http://mnt.to/a/4cQk
Neurosurgeons at the University of Texas-Houston and Children's Memorial Hermann Hospital (Houston, Texas) report on the success they achieved when they removed a hypothalamic hamartoma (HH) from a 10-year-old girl to combat hyperphagia (excessive appetite and compulsive overeating) and consequent unhealthy weight gain.
Hereditary Neuropathy And Chemotherapy-Induced Peripheral Neuropathy May Share Genetic Roots In Some Patients
http://mnt.to/a/4cQh
Seemingly benign differences in genetic code from one person to the next could influence who develops side effects to chemotherapy, a Mayo Clinic study has found. The study identified gene variations that can predispose people to chemotherapy-induced peripheral neuropathy, a condition that is hard to predict and often debilitating enough to cause cancer patients to stop their treatment early.
ALS Drug Effects Highlight Potassium Channel Role In Spinal Muscular Atrophy
http://mnt.to/a/4cQg
There is no specific drug to treat spinal muscular atrophy (SMA), a family of motor neuron diseases that in its most severe form is the leading genetic cause of infant death in the United States and affects one in 6,000 people overall.
Neuroblastomas Vulnerable To Novel Class Of Drugs May Be Identified By Genetic Biomarker
http://mnt.to/a/4cQ9
An irregularity within many neuroblastoma cells may indicate whether a neuroblastoma tumor, a difficult-to-treat, early childhood cancer, is vulnerable to a new class of anti-cancer drugs known as BET bromodomain inhibitors, Dana-Farber/Children's Hospital Cancer Center scientists reported at the annual meeting of the American Association for Cancer Research in Washington, April 6-10.
Study Offers Insights Into Hot And Cold Senses
http://mnt.to/a/4cPp
A study from the University of North Carolina School of Medicine offers new insights into how the nervous system processes hot and cold temperatures. The research led by neuroscientist Mark J.
Shedding Light On A Gene Mutation That Causes Signs Of Premature Aging
http://mnt.to/a/4cPd
Research from Western University and Lawson Health Research Institute sheds new light on a gene called ATRX and its function in the brain and pituitary. Children born with ATRX syndrome have cognitive defects and developmental abnormalities.
----------------------------------------------
** NUTRITION / DIET News **
Packs Of Soda Cause People To Drink More
http://mnt.to/a/4cRn
People buy more soda when they are offered packs of smaller drinks instead of single servings of different sized drinks.The finding came from a new study published in the journal PLOS ONE and was conducted by a team of experts, led by Brent M.
Inhibiting Growth Of Triple-Negative Breast Cancer With Omega-3 Fatty Acids
http://mnt.to/a/4cQm
Researchers from Fox Chase Cancer Center have found that omega-3 fatty acids and their metabolite products slow or stop the proliferation, or growth in the number of cells, of triple-negative breast cancer cells more effectively than cells from luminal types of the disease.
----------------------------------------------
** OBESITY / WEIGHT LOSS / FITNESS News **
Packs Of Soda Cause People To Drink More
http://mnt.to/a/4cRn
People buy more soda when they are offered packs of smaller drinks instead of single servings of different sized drinks.The finding came from a new study published in the journal PLOS ONE and was conducted by a team of experts, led by Brent M.
Compulsive Eating And Excessive Weight Gain Curbed By Removal Of Hypothalamic Hamartoma
http://mnt.to/a/4cQk
Neurosurgeons at the University of Texas-Houston and Children's Memorial Hermann Hospital (Houston, Texas) report on the success they achieved when they removed a hypothalamic hamartoma (HH) from a 10-year-old girl to combat hyperphagia (excessive appetite and compulsive overeating) and consequent unhealthy weight gain.
Obesity May Not Be A Symptom Of Polycystic Ovary Syndrome
http://mnt.to/a/4cPg
The relationship between obesity and polycystic ovary syndrome may be exaggerated, likely because the women who actively seek care for the condition tend to be heavier than those identified through screening of the general population, researchers report.
----------------------------------------------
** OVARIAN CANCER News **
Endometriosis Treatments Lower Ovarian Cancer Risk
http://mnt.to/a/4cR7
A novel study shows women who undergo surgical treatment for endometriosis have a lower risk of developing ovarian cancer. According to results published in Acta Obstetricia et Gynecologica Scandinavica, a journal of the Nordic Federation of Societies of Obstetrics and Gynecology, hormonal treatments for endometriosis did not lower ovarian cancer risk.
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** PAIN / ANESTHETICS News **
Brain Scan Offers First Objective Measure Of Pain
http://mnt.to/a/4cSQ
Using fMRI scans of the brain, US scientists have for the first time developed a method of "seeing" pain and suggest it may lead to reliable ways for doctors to quantify objectively how much pain patients are feeling.
Non-Amputees Experience Phantom Limb Sensation
http://mnt.to/a/4cSN
Non-amputated individuals can actually experience the illusion of having a phantom hand, according to a new study in the Journal of Cognitive Neuroscience.The research was conducted by neuroscientists at the Karolinska Institutet in Sweden who explained that the sensation of having a physical body is not as obvious as some people may assume.
Study Offers Insights Into Hot And Cold Senses
http://mnt.to/a/4cPp
A study from the University of North Carolina School of Medicine offers new insights into how the nervous system processes hot and cold temperatures. The research led by neuroscientist Mark J.
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** PANCREATIC CANCER News **
Promising Phase I Clinical Trial Of Rogosertib Leads To Multi-Institutional Phase II Trial
http://mnt.to/a/4cQ4
Results of a phase 1 clinical trial reported at the American Association for Cancer Research (AACR) annual conference show that orally administered Rigosertib is well tolerated in patients with advanced solid tumors.
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** PEDIATRICS / CHILDREN'S HEALTH News **
Rates Of Childhood Squint Surgery Have Plummeted Over Past 50 Years
http://mnt.to/a/4cR2
But there's still inexplicable fivefold difference in rates across England, similar to wide discrepancies in tonsil removalRates of surgery to correct childhood squint in England have tumbled over the past 50 years, finds research published online in the British Journal of Ophthalmology.
ALS Drug Effects Highlight Potassium Channel Role In Spinal Muscular Atrophy
http://mnt.to/a/4cQg
There is no specific drug to treat spinal muscular atrophy (SMA), a family of motor neuron diseases that in its most severe form is the leading genetic cause of infant death in the United States and affects one in 6,000 people overall.
Neuroblastomas Vulnerable To Novel Class Of Drugs May Be Identified By Genetic Biomarker
http://mnt.to/a/4cQ9
An irregularity within many neuroblastoma cells may indicate whether a neuroblastoma tumor, a difficult-to-treat, early childhood cancer, is vulnerable to a new class of anti-cancer drugs known as BET bromodomain inhibitors, Dana-Farber/Children's Hospital Cancer Center scientists reported at the annual meeting of the American Association for Cancer Research in Washington, April 6-10.
In Pediatric Bone Cancer, K9 Osteosarcoma Samples Identify Drivers Of Metastasis
http://mnt.to/a/4cQ7
Human osteosarcoma samples are hard to come by, making the disease difficult to study. However, K9 bone cancer is genetically indistinguishable from the human form of the disease, and over 10,000 canine patients develop the disease every year.
Kidney Function Of Adolescents May Be Negatively Impacted By Smoking
http://mnt.to/a/4cPq
Exposure to tobacco smoke could negatively impact adolescent kidney function; this is according to a new study led by a team of researchers at the Johns Hopkins Bloomberg School of Public Health and the Johns Hopkins Children's Center.
Helping Men To Become Stepdads
http://mnt.to/a/4cPm
As any stepdad can tell you, it's one thing to win a mom's heart and another to win over her children.Although one-third of American children live in a stepfamily during part of their childhood, little is known about the development of the relationship between stepfathers and stepchildren.
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** PHARMA INDUSTRY / BIOTECH INDUSTRY News **
New Protocol Design Approaches Will Improve Clinical Trial Performance And Efficiency, According To Tufts Center For The Study Of Drug Development
http://mnt.to/a/4cRd
Growing protocol complexity-responsible for longer clinical study times, greater difficulty in recruiting volunteers, and rising drug development costs-is spurring new approaches to optimizing protocol design, according to leaders from the research-based drug industry recently convened by the Tufts Center for the Study of Drug Development.
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** PREGNANCY / OBSTETRICS News **
During Pregnancy, Excess Estrogen Can Silence BRCA1 In Daughters, Increasing Breast Cancer Risk
http://mnt.to/a/4cQ2
Excess estrogen levels during pregnancy can disable, in their daughters, a powerful breast cancer tumor suppressor gene, say researchers at Georgetown Lombardi Comprehensive Cancer Center. They found the DNA repair gene BRCA1 to be silenced in one year-old girls exposed to a high hormonal fetal environment.
Unnecessary Early Deliveries Reduced In Multistate, Hospital-Based Study
http://mnt.to/a/4cPv
A study published in Obstetrics & Gynecology shows that multistate, hospital-based quality improvement programs can be remarkably effective at reducing early elective deliveries of babies.The rate of elective early term deliveries (i.
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** PRIMARY CARE / GENERAL PRACTICE News **
Half Of All Patient Complaints In Australia Are About 3% Of Doctors
http://mnt.to/a/4cR3
"Frequent fliers" concern for health services everywhere, but issue still veiled in secrecyHalf of all formal patient complaints made in Australia to health ombudsmen concern just 3% of the country's doctors, with 1% accounting for a quarter of all complaints, finds research published online in BMJ Quality & Safety.
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** PROSTATE / PROSTATE CANCER News **
Study Identifies A Protein That Helps Trigger Both Normal Fetal Growth And Cancer
http://mnt.to/a/4cQj
Two researchers at the National Institutes of Health discovered a new genetic link between the rapid growth of healthy fetuses and the uncontrolled cell division in cancer. The findings shed light on normal development and on the genetic underpinnings of common cancers.
Study Finds Bird Virus Promising For Prostate Cancer Treatment
http://mnt.to/a/4cPs
A study at the Virginia-Maryland Regional College of Veterinary Medicine has identified a chicken-killing virus as a promising treatment for prostate cancer in humans.Researchers have discovered that a genetically engineered Newcastle disease virus, which harms chickens but not humans, kills prostate cancer cells of all kinds, including hormone-resistant cancer cells.
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** PSYCHOLOGY / PSYCHIATRY News **
Fathers Sharing Household, Parenting Responsibilities Leads To A Better Marriage
http://mnt.to/a/4cPw
Although no exact formula for marital bliss exists, a University of Missouri researcher has found that husbands and wives are happier when they share household and child-rearing responsibilities.
Helping Men To Become Stepdads
http://mnt.to/a/4cPm
As any stepdad can tell you, it's one thing to win a mom's heart and another to win over her children.Although one-third of American children live in a stepfamily during part of their childhood, little is known about the development of the relationship between stepfathers and stepchildren.
A Self-Fulfilling Prophesy: Thinking You're Old And Frail
http://mnt.to/a/4cPf
Older adults who categorise themselves as old and frail encourage attitudinal and behavioural confirmation of that identity.This is the conclusion of a study conducted by Krystal Warmoth and colleagues at University of Exeter Medical School, which was presented at the British Psychological Society Annual Conference in Harrogate, UK.
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** PUBLIC HEALTH News **
Half Of All Patient Complaints In Australia Are About 3% Of Doctors
http://mnt.to/a/4cR3
"Frequent fliers" concern for health services everywhere, but issue still veiled in secrecyHalf of all formal patient complaints made in Australia to health ombudsmen concern just 3% of the country's doctors, with 1% accounting for a quarter of all complaints, finds research published online in BMJ Quality & Safety.
Synthetic Materials Inspired By Bean Leaves May Be A Future Trap For Bedbugs
http://mnt.to/a/4cQc
Inspired by a traditional Balkan bedbug remedy, researchers have documented how microscopic hairs on kidney bean leaves effectively stab and trap the biting insects, according to findings published online in the Journal of the Royal Society Interface.
Rate Of Health Care-Acquired Infections In The ICU Reduced By Copper Surfaces
http://mnt.to/a/4cPC
Placement of copper objects in intensive care unit (ICU) hospital rooms reduced the number of healthcare-acquired infections (HAIs) in patients by more than half, according to a new study published in the May issue of Infection Control and Hospital Epidemiology, the journal of the Society for Healthcare Epidemiology of America, in a special topic issue focused on the role of the environment in infection prevention.
Hydrogen Peroxide Vapor Eradicates Multidrug-Resistant Organisms From Unopened Supplies
http://mnt.to/a/4cPB
In rooms of patients with multidrug-resistant organisms (MDROs), the outside of the packages containing sterile items can become contaminated. Unused medical supplies are often thrown away to prevent the items from becoming pathways for transmission of drug-resistant microbes, and in the process this leads to increased healthcare costs.
Disinfection Intervention Highlights Effective Method In Removing Antibiotic-Resistant Bug
http://mnt.to/a/4cPz
With rates and deaths associated with Clostridium difficile (C. difficile) at historically high levels, many hospitals have taken extra steps to reduce these infections. New research finds that a dedicated daily cleaning crew who adequately clean and disinfect rooms contaminated by C.
Unnecessary Early Deliveries Reduced In Multistate, Hospital-Based Study
http://mnt.to/a/4cPv
A study published in Obstetrics & Gynecology shows that multistate, hospital-based quality improvement programs can be remarkably effective at reducing early elective deliveries of babies.The rate of elective early term deliveries (i.
World Heart Federation Position Statement Published Online In Nature Reviews Cardiology
http://mnt.to/a/4cPt
.
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** RADIOLOGY / NUCLEAR MEDICINE News **
Space Radiation Reduces Ability Of Intestinal Cells To Destroy Oncoprotein, May Increase Colorectal Cancer Risk
http://mnt.to/a/4cQ3
Two studies funded by NASA and presented at the AACR Annual Meeting 2013 help explain why space radiation may increase the risk of colorectal cancer in humans.The researchers, from Georgetown Lombardi Comprehensive Cancer Center, found that cosmic radiation impairs the ability of cells in the intestines of mice to eliminate oncogenic proteins, thus substantially increasing development of colorectal tumors.
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** RESPIRATORY / ASTHMA News **
CPAP Improves Work Productivity For Sleep Apnoea Patients
http://mnt.to/a/4cSq
Continuous positive airway pressure (CPAP) is effective at increasing work productivity, according to a new study.The study will be presented today at the Sleep and Breathing Conference in Berlin, organised by the European Respiratory Society and the European Sleep Research Society.
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** SENIORS / AGING News **
"Death With Dignity" Program Is Rarely Used
http://mnt.to/a/4cSP
Doctors, patients, and their families have been okay with a "Death with Dignity" physician-assisted suicide program that is available to patients with fatal cancer at a Seattle clinic, a study suggests.
Dementia Care Study Confirms Dramatic Reduction In Use Of Antipsychotics And A Range Of Drugs With Corresponding Improvement In Wellbeing
http://mnt.to/a/4cRc
A new study of residents in specialised dementia care homes has confirmed a reduction, averaging 48 per cent, in the requirement for antipsychotic medication, together with dramatic reductions in usage of a range of other medications and a corresponding improvement in the wellbeing of participants.
Shedding Light On A Gene Mutation That Causes Signs Of Premature Aging
http://mnt.to/a/4cR5
Research from Western University and Lawson Health Research Institute sheds new light on a gene called ATRX and its function in the brain and pituitary. Children born with ATRX syndrome have cognitive defects and developmental abnormalities.
Future Disability May Be Predicted By Posture
http://mnt.to/a/4cPk
The shape of an individual's spinal column may predict his or her risk for nursing home admission or need of home assistance in old age, according to a new article published online in the Journals of Gerontology Series A: Biological Sciences and Medical Sciences.
A Self-Fulfilling Prophesy: Thinking You're Old And Frail
http://mnt.to/a/4cPf
Older adults who categorise themselves as old and frail encourage attitudinal and behavioural confirmation of that identity.This is the conclusion of a study conducted by Krystal Warmoth and colleagues at University of Exeter Medical School, which was presented at the British Psychological Society Annual Conference in Harrogate, UK.
Shedding Light On A Gene Mutation That Causes Signs Of Premature Aging
http://mnt.to/a/4cPd
Research from Western University and Lawson Health Research Institute sheds new light on a gene called ATRX and its function in the brain and pituitary. Children born with ATRX syndrome have cognitive defects and developmental abnormalities.
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** SLEEP / SLEEP DISORDERS / INSOMNIA News **
CPAP Improves Work Productivity For Sleep Apnoea Patients
http://mnt.to/a/4cSq
Continuous positive airway pressure (CPAP) is effective at increasing work productivity, according to a new study.The study will be presented today at the Sleep and Breathing Conference in Berlin, organised by the European Respiratory Society and the European Sleep Research Society.
Understanding How Oncogenes Affect The Body Clock May Help Create Better Cancer Treatments
http://mnt.to/a/4cPZ
The Myc oncogene can disrupt the 24-hour internal rhythm in cancer cells. Postdoctoral fellow Brian Altman, PhD, and graduate student Annie Hsieh, MD, both from the in the lab of Chi Van Dang, MD, PhD, director of the Abramson Cancer Center, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, presented their data in the "Metabolic Pathway Regulation in Cancer" session at the 2013 American Association for Cancer Research meeting, Washington, D.
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** SMOKING / QUIT SMOKING News **
Genes Related To The Regulation Of The Cell Cycle Are Associated With Poor Patient Outcomes In Lung And Bladder Cancers
http://mnt.to/a/4cQ8
Believe it or not, while researchers have explored which genes are mutated in each type of tobacco-associated cancer, until now no one had thought to look across these types for common genes that might predict patient outcomes.
Kidney Function Of Adolescents May Be Negatively Impacted By Smoking
http://mnt.to/a/4cPq
Exposure to tobacco smoke could negatively impact adolescent kidney function; this is according to a new study led by a team of researchers at the Johns Hopkins Bloomberg School of Public Health and the Johns Hopkins Children's Center.
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** SPORTS MEDICINE / FITNESS News **
Genetic Predisposition Could Lead To Laziness
http://mnt.to/a/4cPj
Studies show 97 percent of American adults get less than 30 minutes of exercise a day, which is the minimum recommended amount based on federal guidelines. New research from the University of Missouri suggests certain genetic traits may predispose people to being more or less motivated to exercise and remain active.
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** TROPICAL DISEASES News **
Plant Proteins Control Chronic Disease In Toxoplasma Infections
http://mnt.to/a/4cPr
A new discovery about the malaria-related parasite Toxoplasma gondii -- which can threaten babies, AIDS patients, the elderly and others with weakened immune function -- may help solve the mystery of how this single-celled parasite establishes life-long infections in people.
Novel Approach To Developing A Dengue Virus Treatment Using Mutated Antibodies
http://mnt.to/a/4cPn
Nearly half of the world's population is at risk of infection by the dengue virus, yet there is no specific treatment for the disease. Now a therapy to protect people from the virus could finally be a step closer, thanks to a team at MIT.
For Bioterror Threats, Currently Approved Drugs Found Effective In Laboratory Mice
http://mnt.to/a/4cPh
In the most extensive screen of its kind, Texas Biomed scientists in San Antonio have demonstrated the feasibility of repurposing already-approved drugs for use against highly pathogenic bacteria and viruses.
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** UROLOGY / NEPHROLOGY News **
Study Identifies A Protein That Helps Trigger Both Normal Fetal Growth And Cancer
http://mnt.to/a/4cQj
Two researchers at the National Institutes of Health discovered a new genetic link between the rapid growth of healthy fetuses and the uncontrolled cell division in cancer. The findings shed light on normal development and on the genetic underpinnings of common cancers.
Genes Related To The Regulation Of The Cell Cycle Are Associated With Poor Patient Outcomes In Lung And Bladder Cancers
http://mnt.to/a/4cQ8
Believe it or not, while researchers have explored which genes are mutated in each type of tobacco-associated cancer, until now no one had thought to look across these types for common genes that might predict patient outcomes.
Kidney Function Of Adolescents May Be Negatively Impacted By Smoking
http://mnt.to/a/4cPq
Exposure to tobacco smoke could negatively impact adolescent kidney function; this is according to a new study led by a team of researchers at the Johns Hopkins Bloomberg School of Public Health and the Johns Hopkins Children's Center.
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** VETERINARY News **
Combination Therapy Could Be Key In Treating Blindness
http://mnt.to/a/4cPx
Researchers have discovered that using two kinds of therapy in tandem may be a knockout combo against inherited disorders that cause blindness. While their study focused on man's best friend, the treatment could help restore vision in people, too.
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** WOMEN'S HEALTH / GYNECOLOGY News **
Endometriosis Treatments Lower Ovarian Cancer Risk
http://mnt.to/a/4cR7
A novel study shows women who undergo surgical treatment for endometriosis have a lower risk of developing ovarian cancer. According to results published in Acta Obstetricia et Gynecologica Scandinavica, a journal of the Nordic Federation of Societies of Obstetrics and Gynecology, hormonal treatments for endometriosis did not lower ovarian cancer risk.
Obesity May Not Be A Symptom Of Polycystic Ovary Syndrome
http://mnt.to/a/4cPg
The relationship between obesity and polycystic ovary syndrome may be exaggerated, likely because the women who actively seek care for the condition tend to be heavier than those identified through screening of the general population, researchers report.
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