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** ADHD News **
Computer-Based ADHD Assessment Being Trialled In UK Prisons For The First Time
http://mnt.to/a/4dS5
Researchers hope that more accurate diagnosis and assessment can lead to improved inmate behavior and reduce offencesA new ADHD tool is being investigated in the UK prison population for the first time.
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** ALCOHOL / ADDICTION / ILLEGAL DRUGS News **
HIV-Treated Drug Users' Deaths Linked To Food Insecurity
http://mnt.to/a/4dRz
Food insecurity increases the risk of death among injection drug users living with HIV/AIDS even when they are receiving life-prolonging antiretroviral therapy (ART), according to a new study involving Simon Fraser University.
Tobacco Harm Reduction Affected By GP's Belief That Nicotine Is A Harmful Cigarette-Smoke Component
http://mnt.to/a/4dR8
A survey of GPs (general practitioners) in the UK and Sweden revealed that some hold the view that one of the greatest health risks from smoking is nicotine. This belief likely influences health advice to smokers when considering whether to recommend the use of alternative nicotine products.
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** BLOOD / HEMATOLOGY News **
Researchers Identify Novel Approach To Create Red Blood Cells, Platelets In Vitro
http://mnt.to/a/4dS7
Finding could reduce need for blood donations, speed up research on therapies to treat diseasesA study led by Boston University School of Medicine has identified a novel approach to create an unlimited number of human red blood cells and platelets in vitro.
Inostics' Blood-Based Mutation Testing Receives CLIA Certification
http://mnt.to/a/4dS4
Inostics, a molecular diagnostics company that provides blood-based mutation testing,received CLIA (Clinical Laboratory Improvement Amendments) licensure for its clinicallaboratory located in Baltimore, MD.
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** BREAST CANCER News **
MarginProbe System Makes Breast Cancer Surgery More Precise
http://mnt.to/a/4dRy
Any breast cancer surgeon who regularly performs lumpectomies confronts the question "Did I get it all?" Thirty to 60 percent of the time in the U.S., the answer is "no," requiring the patient to undergo a second surgery to remove the remaining tumor.
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** CANCER / ONCOLOGY News **
Can Oral Sex Cause Throat Cancer?
http://mnt.to/a/4dTN
Michael Douglas was diagnosed with throat cancer (oropharyngeal cancer) three years ago. He initially said it was caused by years of heavy smoking, alcohol abuse and stress. However, he recently told The Guardian newspaper that it was caused by oral sex (cunnilingus).
Cheap Vinegar Test Detects Cervical Cancer
http://mnt.to/a/4dSk
A remarkably simple vinegar test in India has managed to lower the rate of cervical cancer deaths by one-third.Healthcare professionals have said that the outcome of the test has been "incredible", stating that it is capable of saving millions of lives.
Cancer Patients In The US Are Suffering From Drug Shortages
http://mnt.to/a/4dSj
Eighty-three percent of cancer doctors have documented that they have experienced oncology drug shortages. Most of them also say their patients' treatments have been affected, according to a study presented at the 2013 American Society of Clinical Oncology.
Inostics' Blood-Based Mutation Testing Receives CLIA Certification
http://mnt.to/a/4dS4
Inostics, a molecular diagnostics company that provides blood-based mutation testing,received CLIA (Clinical Laboratory Improvement Amendments) licensure for its clinicallaboratory located in Baltimore, MD.
Cancer Pain Eased By Therapy That Heats And Destroys Bone Tumors
http://mnt.to/a/4dRN
Patients with cancer that has spread to their bones are often treated with radiation therapy to reduce pain. But if that treatment doesn't work, or can't be used again, a second, effective option now exists.
A Wide Variety Of Advanced Cancers Harbor Abnormalities In HER2 Gene
http://mnt.to/a/4dRM
The HER2 growth-factor gene is known to be over-active in breast and gastro-esophageal cancers. But now, irregularities in the genes 's expression - among them mutations, amplifications, substitutions, and translocations - have been found in 14 different advanced solid tumors.
Splicing Process Hijacked By Oncogene Mutation To Promote Growth And Survival
http://mnt.to/a/4dRF
An international team of researchers - led by principal investigator Paul S. Mischel, MD, a member of the Ludwig Institute for Cancer Research and professor in the Department of Pathology at the University of California, San Diego School of Medicine - has found that a singular gene mutation helps brain cancer cells to not just survive, but grow tumors rapidly by altering the splicing of genes that control cellular metabolism.
Progression Of Glioblastoma May Be Accelerated By Cytomegalovirus
http://mnt.to/a/4dRx
A virus that infects most Americans but that usually remains dormant in the body might speed the progression of an aggressive form of brain cancer when particular genes are shut off in tumor cells, new research shows.
Glioblastoma Patients Treated With Bevacizumab Experience Reduced Cognitive Function And Quality Of Life
http://mnt.to/a/4dRs
Many glioblastoma patients treated with bevacizumab (Avastin®) have significant deterioration in neurocognitive function, symptoms and quality of life. Not only that, the changes often predict treatment outcomes, according to new research from The University of Texas MD Anderson Cancer Center.
Identifying Glioblastoma Patients Most Likely To Benefit From Bevacizumab
http://mnt.to/a/4dRn
A new test may help identify newly diagnosed glioblastoma patients more likely to benefit from bevacizumab (Avastin®), according to new research from The University of Texas MD Anderson Cancer Center.
No Benefit Offered By Bevacizumab For Newly Diagnosed Glioblastoma
http://mnt.to/a/4dRm
The angiogenesis inhibitor bevacizumab (Avastin) failed to increase overall survival (OS) or statistically significant progression-free survival (PFS) for glioblastoma patients in the frontline setting, according to research led by researchers at The University of Texas MD Anderson Cancer Center.
Symptoms Of Burnout Suffered By Many US Oncologists Despite High Career Satisfaction
http://mnt.to/a/4dRk
Even though a majority of U.S. oncologists report satisfaction with their careers, many say they have experienced at least one symptom of burnout, a Mayo Clinic-led study has found. The study was released during the American Society of Clinical Oncology's annual meeting in Chicago.
Sorafenib Stops Tumor Growth And Provides The First Effective Treatment For Thyroid Cancer Patients Who Progress Following Standard Therapies
http://mnt.to/a/4dRj
The kidney and liver cancer drug sorafenib holds metastatic thyroid cancer at bay for nearly twice as long as a placebo, according to results of a randomized phase III trial, which was presented by a researcher from the Abramson Cancer Center and the Perelman School of Medicine at the University of Pennsylvania in a plenary session during the American Society of Clinical Oncology's annual meeting (Abstract #4).
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** CARDIOVASCULAR / CARDIOLOGY News **
Statin Use May Be Linked To Musculoskeletal Conditions And Injuries
http://mnt.to/a/4dTC
The usage of statins, drugs to treat high cholesterol, may be linked to musculoskeletal conditions, joint diseases (arthropathies) and injuries, researchers from VA North Texas Health Care System, Dallas, reported in the journal JAMA Internal Medicine.
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** CERVICAL CANCER / HPV VACCINE News **
Cheap Vinegar Test Detects Cervical Cancer
http://mnt.to/a/4dSk
A remarkably simple vinegar test in India has managed to lower the rate of cervical cancer deaths by one-third.Healthcare professionals have said that the outcome of the test has been "incredible", stating that it is capable of saving millions of lives.
Researchers Discover New Weapon In Fight Against Cervical Cancer
http://mnt.to/a/4dS6
Scientists at the University of Leeds have found a way to target and destroy a key protein associated with the development of cervical and other cancers.The E7 protein is produced early in the lifecycle of the human papillomavirus (HPV) and blocks the body's natural defences against the uncontrolled division of cells that can lead to cancer.
Long-Term Sex Partners Of People With HPV-Related Oral Cancers Not At Increased Risk Of Infection
http://mnt.to/a/4dRq
Spouses and long-term partners of patients with mouth and throat cancers related to infection with the human papilloma virus (HPV) appear to have no increased prevalence of oral HPV infections, according to results of a multicenter, pilot study led by Johns Hopkins investigators.
Personalized Strategies For Pretesting Cervical Tumors
http://mnt.to/a/4dR9
Doctors at Washington University School of Medicine in St. Louis have shown that testing cervical tumors before treatment for vulnerability to chemotherapy predicts whether patients will do well or poorly with standard treatment.
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** CHOLESTEROL News **
Statin Use May Be Linked To Musculoskeletal Conditions And Injuries
http://mnt.to/a/4dTC
The usage of statins, drugs to treat high cholesterol, may be linked to musculoskeletal conditions, joint diseases (arthropathies) and injuries, researchers from VA North Texas Health Care System, Dallas, reported in the journal JAMA Internal Medicine.
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** DEPRESSION News **
Ketamine Effective At Treating Depression
http://mnt.to/a/4dTP
Researchers at Mayo Clinic have found that the general anesthetic, Ketamine, is very effective at treating depression when administered over a long period.The study, published in the Journal of Psychopharmacology, revealed that prolonged, low-dose intravenous infusions of Ketamine, have excellent potential in reducing the symptoms of severe depression.
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** DERMATOLOGY News **
News From The Annals Of Internal Medicine: June 4, 2013
http://mnt.to/a/4dSp
1. Daily Sunscreen Use Slows Skin Aging - Even in Middle-AgeFor the first time, science proves that daily sunscreen use significantly slows skin aging, even in middle-aged men and women. Sunscreen and antioxidants have long been advocated to prevent skin aging, but to date, there has been no scientific evidence of their effectiveness.
Identification Of Growth Factor Responsible For Triggering Hair Follicle Generation During Wound Healing
http://mnt.to/a/4dRL
Researchers in the Perelman School of Medicine at the University of Pennsylvania have determined the role of a key growth factor, found in skin cells of limited quantities in humans, which helps hair follicles form and regenerate during the wound healing process.
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** EAR, NOSE AND THROAT News **
Can Oral Sex Cause Throat Cancer?
http://mnt.to/a/4dTN
Michael Douglas was diagnosed with throat cancer (oropharyngeal cancer) three years ago. He initially said it was caused by years of heavy smoking, alcohol abuse and stress. However, he recently told The Guardian newspaper that it was caused by oral sex (cunnilingus).
Long-Term Sex Partners Of People With HPV-Related Oral Cancers Not At Increased Risk Of Infection
http://mnt.to/a/4dRq
Spouses and long-term partners of patients with mouth and throat cancers related to infection with the human papilloma virus (HPV) appear to have no increased prevalence of oral HPV infections, according to results of a multicenter, pilot study led by Johns Hopkins investigators.
Sorafenib Stops Tumor Growth And Provides The First Effective Treatment For Thyroid Cancer Patients Who Progress Following Standard Therapies
http://mnt.to/a/4dRj
The kidney and liver cancer drug sorafenib holds metastatic thyroid cancer at bay for nearly twice as long as a placebo, according to results of a randomized phase III trial, which was presented by a researcher from the Abramson Cancer Center and the Perelman School of Medicine at the University of Pennsylvania in a plenary session during the American Society of Clinical Oncology's annual meeting (Abstract #4).
----------------------------------------------
** ENDOCRINOLOGY News **
Sorafenib Stops Tumor Growth And Provides The First Effective Treatment For Thyroid Cancer Patients Who Progress Following Standard Therapies
http://mnt.to/a/4dRj
The kidney and liver cancer drug sorafenib holds metastatic thyroid cancer at bay for nearly twice as long as a placebo, according to results of a randomized phase III trial, which was presented by a researcher from the Abramson Cancer Center and the Perelman School of Medicine at the University of Pennsylvania in a plenary session during the American Society of Clinical Oncology's annual meeting (Abstract #4).
----------------------------------------------
** EYE HEALTH / BLINDNESS News **
In Metastatic Uveal Melanoma, New Drug Improves Progression-Free Survival, Shrinks Tumors
http://mnt.to/a/4dRr
The experimental drug selumetinib is the first targeted therapy to demonstrate significant clinical benefit for patients with metastatic uveal melanoma, according to new Memorial Sloan-Kettering Cancer Center research presented at the 49th annual meeting of the American Society of Clinical Oncology (ASCO).
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** FIBROMYALGIA News **
Weather Conditions Do Not Affect Fibromyalgia Pain Or Fatigue
http://mnt.to/a/4dTG
Individual Patients May Experience Some Weather SensitivityDutch researchers report that weather conditions including temperature, sunshine, and precipitation have no impact on fibromyalgia symptoms in female patients.
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** GASTROINTESTINAL / GASTROENTEROLOGY News **
Poultry Contamination On Farm Linked To Contamination At Processing Plant
http://mnt.to/a/4dRD
Researchers at the University of Georgia, Athens, have identified a strong link between the prevalence and load of certain food-borne pathogens on poultry farms, and later downstream at the processing plant.
Body's Response To Intestinal Infections Controlled By Circadian Rhythms
http://mnt.to/a/4dRb
Circadian rhythms can boost the body's ability to fight intestinal bacterial infections, UC Irvine researchers have found.This suggests that targeted treatments may be particularly effective for pathogens such as salmonella that prompt a strong immune system response governed by circadian genes.
----------------------------------------------
** GENETICS News **
Unraveling Tumor Growth One Stem Cell At A Time
http://mnt.to/a/4dTy
Researchers at the University of Cambridge have discovered that a single mutation in a leukemia-associated gene reduces the ability of blood stem cells to make more blood stem cells, but leaves their progeny daughter cells unaffected.
News From The Journal Of Clinical Investigation: June 3, 2013
http://mnt.to/a/4dSr
A potential gene therapy for Mucopolysaccharidosis Type IIIAMucopolysaccharidosis Type IIIA (MPSIIIA) is a metabolic disorder in which the body is missing an enzyme that is required to break down long chains of sugars known as glycosaminoglycans.
A Grassy Trend In Human Ancestors' Diets
http://mnt.to/a/4dS2
Tooth Enamel Shows Surprising Change in Our Ancient BuffetMost apes eat leaves and fruits from trees and shrubs. New studies spearheaded by the University of Utah show that human ancestors expanded their menu 3.
Higher-Producing, Better-Tasting Chocolate Likely Following Genome Sequencing Of Cacao Plant
http://mnt.to/a/4dRT
The freshly sequenced genome of the most commonly cultivated cacao plant in the world is revealed in the open access journal Genome Biology. Researchers have utilised high quality DNA sequences to demonstrate the usefulness and quality of the sequence to identify genetic markers that can lead to higher yielding cocoa plants that still produce better tasting cocoa.
A Wide Variety Of Advanced Cancers Harbor Abnormalities In HER2 Gene
http://mnt.to/a/4dRM
The HER2 growth-factor gene is known to be over-active in breast and gastro-esophageal cancers. But now, irregularities in the genes 's expression - among them mutations, amplifications, substitutions, and translocations - have been found in 14 different advanced solid tumors.
Mass-Producing High-Quality DNA Molecules Using New Method
http://mnt.to/a/4dRJ
A new method of manufacturing short, single-stranded DNA molecules can solve many of the problems associated with current production methods. The new method, which is described in the scientific periodical Nature Methods, can be of value to both DNA nanotechnology and the development of drugs consisting of DNA fragments.
Splicing Process Hijacked By Oncogene Mutation To Promote Growth And Survival
http://mnt.to/a/4dRF
An international team of researchers - led by principal investigator Paul S. Mischel, MD, a member of the Ludwig Institute for Cancer Research and professor in the Department of Pathology at the University of California, San Diego School of Medicine - has found that a singular gene mutation helps brain cancer cells to not just survive, but grow tumors rapidly by altering the splicing of genes that control cellular metabolism.
Lung Cancer Outcomes Boosted By Targeted Therapy
http://mnt.to/a/4dRt
Thousands of patients with an advanced form of lung cancer that carries a specific dysfunctional gene are likely to fare better if treated with a targeted therapy than with traditional chemotherapy, report Dana-Farber Cancer Institute researchers and a team of international collaborators.
Lead Exposure May Trigger Schizophrenia
http://mnt.to/a/4dRc
Mice engineered with a human gene for schizophrenia and exposed to lead during early life exhibited behaviors and structural changes in their brains consistent with schizophrenia. Scientists at Columbia University's Mailman School of Public Health and the Johns Hopkins University School of Medicine say their findings suggest a synergistic effect between lead exposure and a genetic risk factor, and open an avenue to better understanding the complex gene-environment interactions that put people at risk for schizophrenia and other mental disorders.
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** HIV / AIDS News **
Mathematical Analysis Of Viral Blips
http://mnt.to/a/4dRC
Recurrent infection is a common feature of persistent viral diseases. It includes episodes of high viral production interspersed by periods of relative quiescence. These quiescent or silent stages are hard to study with experimental models.
Researchers Employ Mathematical Models To Better Combat HIV
http://mnt.to/a/4dRB
The first few hours to days following exposure to human immunodeficiency virus (HIV) can be of critical importance in determining if infection occurs in a patient. But the low numbers of viruses and infected cells at this stage makes it very difficult to study these events in humans or animal models.
HIV-Treated Drug Users' Deaths Linked To Food Insecurity
http://mnt.to/a/4dRz
Food insecurity increases the risk of death among injection drug users living with HIV/AIDS even when they are receiving life-prolonging antiretroviral therapy (ART), according to a new study involving Simon Fraser University.
Reduction In Child Mortality And Improvements In Maternal Health
http://mnt.to/a/4dRg
Rapid expansion of programs to prevent HIV transmission to babies and vaccinate children show how results can be achieved in relatively little timeSome of the world's poorest countries have managed to cut maternal and young child mortality rates by half or more, according to a new report from Countdown to 2015.
Advances In HIV Care And Increased Focus On LGBT Health Lead To Improvement In HIV Treatment Adherence And Outcomes
http://mnt.to/a/4dRf
HIV-positive transgender people are just as likely to stay in care, take their medication and have similar outcomes as other men and women living with the disease, according to new research from the Perelman School of Medicine at the University of Pennsylvania and published online May 30 in Clinical Infectious Diseases.
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** IMMUNE SYSTEM / VACCINES News **
In Multiple Sclerosis-like Disease, Enhanced White Blood Cells Heal Mice
http://mnt.to/a/4dRw
Genetically engineered immune cells seem to promote healing in mice infected with a neurological disease similar to multiple sclerosis (MS), cleaning up lesions and allowing the mice to regain use of their legs and tails.
Body's Response To Intestinal Infections Controlled By Circadian Rhythms
http://mnt.to/a/4dRb
Circadian rhythms can boost the body's ability to fight intestinal bacterial infections, UC Irvine researchers have found.This suggests that targeted treatments may be particularly effective for pathogens such as salmonella that prompt a strong immune system response governed by circadian genes.
----------------------------------------------
** INFECTIOUS DISEASES / BACTERIA / VIRUSES News **
Poultry Contamination On Farm Linked To Contamination At Processing Plant
http://mnt.to/a/4dRD
Researchers at the University of Georgia, Athens, have identified a strong link between the prevalence and load of certain food-borne pathogens on poultry farms, and later downstream at the processing plant.
Mathematical Analysis Of Viral Blips
http://mnt.to/a/4dRC
Recurrent infection is a common feature of persistent viral diseases. It includes episodes of high viral production interspersed by periods of relative quiescence. These quiescent or silent stages are hard to study with experimental models.
Progression Of Glioblastoma May Be Accelerated By Cytomegalovirus
http://mnt.to/a/4dRx
A virus that infects most Americans but that usually remains dormant in the body might speed the progression of an aggressive form of brain cancer when particular genes are shut off in tumor cells, new research shows.
Body's Response To Intestinal Infections Controlled By Circadian Rhythms
http://mnt.to/a/4dRb
Circadian rhythms can boost the body's ability to fight intestinal bacterial infections, UC Irvine researchers have found.This suggests that targeted treatments may be particularly effective for pathogens such as salmonella that prompt a strong immune system response governed by circadian genes.
----------------------------------------------
** IT / INTERNET / E-MAIL News **
Computer-Based ADHD Assessment Being Trialled In UK Prisons For The First Time
http://mnt.to/a/4dS5
Researchers hope that more accurate diagnosis and assessment can lead to improved inmate behavior and reduce offencesA new ADHD tool is being investigated in the UK prison population for the first time.
----------------------------------------------
** LIVER DISEASE / HEPATITIS News **
Groundbreaking Research - MIT Scientists Produce Artificial Liver Tissue
http://mnt.to/a/4dSn
Groundbreaking research conducted at MIT has found a way of growing liver cells in a lab dish, capable of producing new liver tissue.The liver is capable of regenerating itself if a part of it is removed.
Artificial Livers A Step Closer
http://mnt.to/a/4dRP
Prometheus, the mythological figure who stole fire from the gods, was punished for this theft by being bound to a rock. Each day, an eagle swept down and fed on his liver, which then grew back to be eaten again the next day.
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** LUNG CANCER News **
Crizotinib's Superiority To Chemotherapy For ALK-positive Lung Cancer Confirmed; First Crizotinib Resistance In ROS1-positive Lung Tumor
http://mnt.to/a/4dRv
Research teams led by Massachusetts General Hospital (MGH) Cancer Center investigators are publishing two important studies regarding use of the targeted cancer drug crizotinib for treatment of advanced lung cancer driven by specific genetic mutations.
Lung Cancer Outcomes Boosted By Targeted Therapy
http://mnt.to/a/4dRt
Thousands of patients with an advanced form of lung cancer that carries a specific dysfunctional gene are likely to fare better if treated with a targeted therapy than with traditional chemotherapy, report Dana-Farber Cancer Institute researchers and a team of international collaborators.
----------------------------------------------
** MEDICAL DEVICES / DIAGNOSTICS News **
Artificial Livers A Step Closer
http://mnt.to/a/4dRP
Prometheus, the mythological figure who stole fire from the gods, was punished for this theft by being bound to a rock. Each day, an eagle swept down and fed on his liver, which then grew back to be eaten again the next day.
MarginProbe System Makes Breast Cancer Surgery More Precise
http://mnt.to/a/4dRy
Any breast cancer surgeon who regularly performs lumpectomies confronts the question "Did I get it all?" Thirty to 60 percent of the time in the U.S., the answer is "no," requiring the patient to undergo a second surgery to remove the remaining tumor.
----------------------------------------------
** MEDICAL PRACTICE MANAGEMENT News **
News From The Annals Of Internal Medicine: June 4, 2013
http://mnt.to/a/4dSp
1. Daily Sunscreen Use Slows Skin Aging - Even in Middle-AgeFor the first time, science proves that daily sunscreen use significantly slows skin aging, even in middle-aged men and women. Sunscreen and antioxidants have long been advocated to prevent skin aging, but to date, there has been no scientific evidence of their effectiveness.
----------------------------------------------
** MELANOMA / SKIN CANCER News **
Daily Sunscreen Use Prevents Skin Aging
http://mnt.to/a/4dTM
Daily sunscreen use greatly reduces skin aging, even in middle-aged men and women, according to new research in the Annals of Internal Medicine.Sunscreen and antioxidants have historically been shown to prevent skin aging, however, there has been no scientific evidence of their effectiveness.
Promising New Treatment For Advanced Melanoma
http://mnt.to/a/4dRK
Researchers from UCLA's Jonsson Comprehensive Cancer Center report that a new drug in preliminary tests has shown promising results with very manageable side effects for treating patients with melanoma, the deadliest form of skin cancer.
In Metastatic Uveal Melanoma, New Drug Improves Progression-Free Survival, Shrinks Tumors
http://mnt.to/a/4dRr
The experimental drug selumetinib is the first targeted therapy to demonstrate significant clinical benefit for patients with metastatic uveal melanoma, according to new Memorial Sloan-Kettering Cancer Center research presented at the 49th annual meeting of the American Society of Clinical Oncology (ASCO).
----------------------------------------------
** MENTAL HEALTH News **
Surgery For Obsessive Compulsive Disorder Sufferers Is Safe And Effective
http://mnt.to/a/4dSb
Around half of patients with extreme OCD respond well to psychosurgery treatmentAround half of people with an extreme form of obsessive compulsive disorder responded well to a type of psychosurgery that proved to be safe and effective, according to research published online in the Journal of Neurology, Neurosurgery, & Psychiatry.
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** MRI / PET / ULTRASOUND News **
Cancer Pain Eased By Therapy That Heats And Destroys Bone Tumors
http://mnt.to/a/4dRN
Patients with cancer that has spread to their bones are often treated with radiation therapy to reduce pain. But if that treatment doesn't work, or can't be used again, a second, effective option now exists.
----------------------------------------------
** MULTIPLE SCLEROSIS News **
In Multiple Sclerosis-like Disease, Enhanced White Blood Cells Heal Mice
http://mnt.to/a/4dRw
Genetically engineered immune cells seem to promote healing in mice infected with a neurological disease similar to multiple sclerosis (MS), cleaning up lesions and allowing the mice to regain use of their legs and tails.
----------------------------------------------
** NEUROLOGY / NEUROSCIENCE News **
News From The Journal Of Clinical Investigation: June 3, 2013
http://mnt.to/a/4dSr
A potential gene therapy for Mucopolysaccharidosis Type IIIAMucopolysaccharidosis Type IIIA (MPSIIIA) is a metabolic disorder in which the body is missing an enzyme that is required to break down long chains of sugars known as glycosaminoglycans.
Progression Of Glioblastoma May Be Accelerated By Cytomegalovirus
http://mnt.to/a/4dRx
A virus that infects most Americans but that usually remains dormant in the body might speed the progression of an aggressive form of brain cancer when particular genes are shut off in tumor cells, new research shows.
Glioblastoma Patients Treated With Bevacizumab Experience Reduced Cognitive Function And Quality Of Life
http://mnt.to/a/4dRs
Many glioblastoma patients treated with bevacizumab (Avastin®) have significant deterioration in neurocognitive function, symptoms and quality of life. Not only that, the changes often predict treatment outcomes, according to new research from The University of Texas MD Anderson Cancer Center.
Identifying Glioblastoma Patients Most Likely To Benefit From Bevacizumab
http://mnt.to/a/4dRn
A new test may help identify newly diagnosed glioblastoma patients more likely to benefit from bevacizumab (Avastin®), according to new research from The University of Texas MD Anderson Cancer Center.
No Benefit Offered By Bevacizumab For Newly Diagnosed Glioblastoma
http://mnt.to/a/4dRm
The angiogenesis inhibitor bevacizumab (Avastin) failed to increase overall survival (OS) or statistically significant progression-free survival (PFS) for glioblastoma patients in the frontline setting, according to research led by researchers at The University of Texas MD Anderson Cancer Center.
----------------------------------------------
** NUTRITION / DIET News **
Increased TV Exposure Associated With Higher Consumption Of Sweetened Beverages Among Children
http://mnt.to/a/4dSG
More time in front of the TV set and higher exposure to TV adverts may lead to increased consumption of sweetened beverages among children. This is the conclusion of a new study from the University of Gothenburg, Sweden.
Vegetarians Live Longer Than Meat-Eaters
http://mnt.to/a/4dSm
Vegetarians may live longer than meat-eaters, according to a new study published in JAMA Internal Medicine.The research involved over 70,000 members of the Seventh-day Adventist Church and showed that vegetarian diets are linked to reduced death rates with more favorable results for males than females.
A Grassy Trend In Human Ancestors' Diets
http://mnt.to/a/4dS2
Tooth Enamel Shows Surprising Change in Our Ancient BuffetMost apes eat leaves and fruits from trees and shrubs. New studies spearheaded by the University of Utah show that human ancestors expanded their menu 3.
Higher-Producing, Better-Tasting Chocolate Likely Following Genome Sequencing Of Cacao Plant
http://mnt.to/a/4dRT
The freshly sequenced genome of the most commonly cultivated cacao plant in the world is revealed in the open access journal Genome Biology. Researchers have utilised high quality DNA sequences to demonstrate the usefulness and quality of the sequence to identify genetic markers that can lead to higher yielding cocoa plants that still produce better tasting cocoa.
HIV-Treated Drug Users' Deaths Linked To Food Insecurity
http://mnt.to/a/4dRz
Food insecurity increases the risk of death among injection drug users living with HIV/AIDS even when they are receiving life-prolonging antiretroviral therapy (ART), according to a new study involving Simon Fraser University.
----------------------------------------------
** OBESITY / WEIGHT LOSS / FITNESS News **
Increased TV Exposure Associated With Higher Consumption Of Sweetened Beverages Among Children
http://mnt.to/a/4dSG
More time in front of the TV set and higher exposure to TV adverts may lead to increased consumption of sweetened beverages among children. This is the conclusion of a new study from the University of Gothenburg, Sweden.
----------------------------------------------
** PAIN / ANESTHETICS News **
Experts Call For International Consensus On Determination Of Death
http://mnt.to/a/4dRS
The criteria used to diagnose both circulatory and brain death in a patient are subject to variability and as such can be controversial. Anaesthesiologists play an important role in procedures related to the determination of death, so should have specific knowledge about medical, ethical and legal criteria of brain death definition.
Cancer Pain Eased By Therapy That Heats And Destroys Bone Tumors
http://mnt.to/a/4dRN
Patients with cancer that has spread to their bones are often treated with radiation therapy to reduce pain. But if that treatment doesn't work, or can't be used again, a second, effective option now exists.
----------------------------------------------
** PALLIATIVE CARE / HOSPICE CARE News **
Less Than Half Of Dying Patients Are Placed On A Nationally Recommended Care Pathway
http://mnt.to/a/4dSc
Lack of knowledge and eligibility is stopping half of terminal patients from going on the Liverpool Care PathwayLess than half of terminally ill patients are placed on the Liverpool Care Pathway for the Dying Patient (LCP) despite it being recommended nationally, concludes UK research published online in the BMJ Supportive & Palliative Care journal.
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** PARKINSON'S DISEASE News **
Disease Mutations And The Parkin Protein
http://mnt.to/a/4dRd
Researchers at the MRC Laboratory of Molecular Biology in the United Kingdom have determined the crystal structure of Parkin, a protein found in cells that when mutated can lead to a hereditary form of Parkinson's disease.
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** PEDIATRICS / CHILDREN'S HEALTH News **
Increased TV Exposure Associated With Higher Consumption Of Sweetened Beverages Among Children
http://mnt.to/a/4dSG
More time in front of the TV set and higher exposure to TV adverts may lead to increased consumption of sweetened beverages among children. This is the conclusion of a new study from the University of Gothenburg, Sweden.
Europe In 2010: Concern Over The Health And Care Of Pregnant Women And Babies
http://mnt.to/a/4dRh
The burden of mortality and morbidity in the perinatal period - pregnancy, childbirth, and the postpartum - remains a major concern in Europe. Over 5 million women deliver babies in European countries every year.
Reduction In Child Mortality And Improvements In Maternal Health
http://mnt.to/a/4dRg
Rapid expansion of programs to prevent HIV transmission to babies and vaccinate children show how results can be achieved in relatively little timeSome of the world's poorest countries have managed to cut maternal and young child mortality rates by half or more, according to a new report from Countdown to 2015.
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** PHARMA INDUSTRY / BIOTECH INDUSTRY News **
Drug Companies' Patent-Extending Strategies Substantially Increases Health Care Costs
http://mnt.to/a/4dTF
Evergreening strategies--where pharmaceutical companies slightly change the formulation of their brand drug into "follow on" drugs by combining formulations or producing slow-release forms, for example, so that they can extend the patent--substantially contributed to an increase in overall healthcare costs in the Swiss canton of Geneva, according to a study by international researchers published in this week's PLOS Medicine.
Cancer Patients In The US Are Suffering From Drug Shortages
http://mnt.to/a/4dSj
Eighty-three percent of cancer doctors have documented that they have experienced oncology drug shortages. Most of them also say their patients' treatments have been affected, according to a study presented at the 2013 American Society of Clinical Oncology.
Mass-Producing High-Quality DNA Molecules Using New Method
http://mnt.to/a/4dRJ
A new method of manufacturing short, single-stranded DNA molecules can solve many of the problems associated with current production methods. The new method, which is described in the scientific periodical Nature Methods, can be of value to both DNA nanotechnology and the development of drugs consisting of DNA fragments.
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** PHARMACY / PHARMACIST News **
Cancer Patients In The US Are Suffering From Drug Shortages
http://mnt.to/a/4dSj
Eighty-three percent of cancer doctors have documented that they have experienced oncology drug shortages. Most of them also say their patients' treatments have been affected, according to a study presented at the 2013 American Society of Clinical Oncology.
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** PREGNANCY / OBSTETRICS News **
Europe In 2010: Concern Over The Health And Care Of Pregnant Women And Babies
http://mnt.to/a/4dRh
The burden of mortality and morbidity in the perinatal period - pregnancy, childbirth, and the postpartum - remains a major concern in Europe. Over 5 million women deliver babies in European countries every year.
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** PRIMARY CARE / GENERAL PRACTICE News **
Vitamin D Tests And Deficiency: New Patient Resource For GPs
http://mnt.to/a/4dS3
A new patient information leaflet on vitamin D deficiency will be available from next week for GPs to use with their patients. The leaflet is part of a suite of resources developed for the latest NPS MedicineWise educational program on preventive activities in general practice.
Symptoms Of Burnout Suffered By Many US Oncologists Despite High Career Satisfaction
http://mnt.to/a/4dRk
Even though a majority of U.S. oncologists report satisfaction with their careers, many say they have experienced at least one symptom of burnout, a Mayo Clinic-led study has found. The study was released during the American Society of Clinical Oncology's annual meeting in Chicago.
Tobacco Harm Reduction Affected By GP's Belief That Nicotine Is A Harmful Cigarette-Smoke Component
http://mnt.to/a/4dR8
A survey of GPs (general practitioners) in the UK and Sweden revealed that some hold the view that one of the greatest health risks from smoking is nicotine. This belief likely influences health advice to smokers when considering whether to recommend the use of alternative nicotine products.
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** PROSTATE / PROSTATE CANCER News **
News From The Journal Of Clinical Investigation: June 3, 2013
http://mnt.to/a/4dSr
A potential gene therapy for Mucopolysaccharidosis Type IIIAMucopolysaccharidosis Type IIIA (MPSIIIA) is a metabolic disorder in which the body is missing an enzyme that is required to break down long chains of sugars known as glycosaminoglycans.
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** PSYCHOLOGY / PSYCHIATRY News **
Symptoms Of Burnout Suffered By Many US Oncologists Despite High Career Satisfaction
http://mnt.to/a/4dRk
Even though a majority of U.S. oncologists report satisfaction with their careers, many say they have experienced at least one symptom of burnout, a Mayo Clinic-led study has found. The study was released during the American Society of Clinical Oncology's annual meeting in Chicago.
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** PUBLIC HEALTH News **
Drug Companies' Patent-Extending Strategies Substantially Increases Health Care Costs
http://mnt.to/a/4dTF
Evergreening strategies--where pharmaceutical companies slightly change the formulation of their brand drug into "follow on" drugs by combining formulations or producing slow-release forms, for example, so that they can extend the patent--substantially contributed to an increase in overall healthcare costs in the Swiss canton of Geneva, according to a study by international researchers published in this week's PLOS Medicine.
Experts Call For International Consensus On Determination Of Death
http://mnt.to/a/4dRS
The criteria used to diagnose both circulatory and brain death in a patient are subject to variability and as such can be controversial. Anaesthesiologists play an important role in procedures related to the determination of death, so should have specific knowledge about medical, ethical and legal criteria of brain death definition.
Relationship Between Shift Work, Sleep And Health Amongst Shift Workers
http://mnt.to/a/4dRG
The study indicates that it isn't only the shift system itself, but rather long working days over a two-week period in the North Sea that affect sleep, says Siri Waage. During a typical 14-day work period in the North Sea, the workers will work twelve hours a day whether doing night or day shift.
Poultry Contamination On Farm Linked To Contamination At Processing Plant
http://mnt.to/a/4dRD
Researchers at the University of Georgia, Athens, have identified a strong link between the prevalence and load of certain food-borne pathogens on poultry farms, and later downstream at the processing plant.
Clinical Practice Guidelines On Sleep Apnea And Driving Published By The American Thoracic Society
http://mnt.to/a/4dRp
The American Thoracic Society has released new clinical practice guidelines on sleep apnea, sleepiness, and driving risk on non-commercial drivers.The new guidelines, which are an update of a 1994 ATS statement on this topic, appear in the American Journal of Respiratory and Critical Care Medicine.
Flames Can Change The Sound Of A Firefighters' Personal Safety Alarm
http://mnt.to/a/4dR7
The PASS, short for "Personal Alert Safety System," has been used by firefighters for thirty years to help track members of their team who might be injured and need assistance to escape a fire.
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** REGULATORY AFFAIRS / DRUG APPROVALS News **
Inostics' Blood-Based Mutation Testing Receives CLIA Certification
http://mnt.to/a/4dS4
Inostics, a molecular diagnostics company that provides blood-based mutation testing,received CLIA (Clinical Laboratory Improvement Amendments) licensure for its clinicallaboratory located in Baltimore, MD.
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** SCHIZOPHRENIA News **
Lead Exposure May Trigger Schizophrenia
http://mnt.to/a/4dRc
Mice engineered with a human gene for schizophrenia and exposed to lead during early life exhibited behaviors and structural changes in their brains consistent with schizophrenia. Scientists at Columbia University's Mailman School of Public Health and the Johns Hopkins University School of Medicine say their findings suggest a synergistic effect between lead exposure and a genetic risk factor, and open an avenue to better understanding the complex gene-environment interactions that put people at risk for schizophrenia and other mental disorders.
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** SENIORS / AGING News **
Daily Sunscreen Use Prevents Skin Aging
http://mnt.to/a/4dTM
Daily sunscreen use greatly reduces skin aging, even in middle-aged men and women, according to new research in the Annals of Internal Medicine.Sunscreen and antioxidants have historically been shown to prevent skin aging, however, there has been no scientific evidence of their effectiveness.
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** SEXUAL HEALTH / STDS News **
Can Oral Sex Cause Throat Cancer?
http://mnt.to/a/4dTN
Michael Douglas was diagnosed with throat cancer (oropharyngeal cancer) three years ago. He initially said it was caused by years of heavy smoking, alcohol abuse and stress. However, he recently told The Guardian newspaper that it was caused by oral sex (cunnilingus).
Long-Term Sex Partners Of People With HPV-Related Oral Cancers Not At Increased Risk Of Infection
http://mnt.to/a/4dRq
Spouses and long-term partners of patients with mouth and throat cancers related to infection with the human papilloma virus (HPV) appear to have no increased prevalence of oral HPV infections, according to results of a multicenter, pilot study led by Johns Hopkins investigators.
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** SLEEP / SLEEP DISORDERS / INSOMNIA News **
Relationship Between Shift Work, Sleep And Health Amongst Shift Workers
http://mnt.to/a/4dRG
The study indicates that it isn't only the shift system itself, but rather long working days over a two-week period in the North Sea that affect sleep, says Siri Waage. During a typical 14-day work period in the North Sea, the workers will work twelve hours a day whether doing night or day shift.
Clinical Practice Guidelines On Sleep Apnea And Driving Published By The American Thoracic Society
http://mnt.to/a/4dRp
The American Thoracic Society has released new clinical practice guidelines on sleep apnea, sleepiness, and driving risk on non-commercial drivers.The new guidelines, which are an update of a 1994 ATS statement on this topic, appear in the American Journal of Respiratory and Critical Care Medicine.
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** SMOKING / QUIT SMOKING News **
Staff Who Smoke Cost Companies Thousands Of Pounds More To Employ
http://mnt.to/a/4dS9
Average employee who smokes costs around £4,000 more a year than a non-smoker due to time off, smoking breaks and healthcare costsEmployers have to pay around £4,000 more a year to employ a member of staff who smokes compared to a non-smoking employee, finds research published online in the Tobacco Control journal.
Tobacco Harm Reduction Affected By GP's Belief That Nicotine Is A Harmful Cigarette-Smoke Component
http://mnt.to/a/4dR8
A survey of GPs (general practitioners) in the UK and Sweden revealed that some hold the view that one of the greatest health risks from smoking is nicotine. This belief likely influences health advice to smokers when considering whether to recommend the use of alternative nicotine products.
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** STATINS News **
Statin Use May Be Linked To Musculoskeletal Conditions And Injuries
http://mnt.to/a/4dTC
The usage of statins, drugs to treat high cholesterol, may be linked to musculoskeletal conditions, joint diseases (arthropathies) and injuries, researchers from VA North Texas Health Care System, Dallas, reported in the journal JAMA Internal Medicine.
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** STEM CELL RESEARCH News **
Unraveling Tumor Growth One Stem Cell At A Time
http://mnt.to/a/4dTy
Researchers at the University of Cambridge have discovered that a single mutation in a leukemia-associated gene reduces the ability of blood stem cells to make more blood stem cells, but leaves their progeny daughter cells unaffected.
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** TRANSPLANTS / ORGAN DONATIONS News **
Groundbreaking Research - MIT Scientists Produce Artificial Liver Tissue
http://mnt.to/a/4dSn
Groundbreaking research conducted at MIT has found a way of growing liver cells in a lab dish, capable of producing new liver tissue.The liver is capable of regenerating itself if a part of it is removed.
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** UROLOGY / NEPHROLOGY News **
Kidney Expert Warns People Are 'In Denial' About Dehydration
http://mnt.to/a/4dS8
A leading surgeon is warning many people in the UK are "in denial" about the consequences of dehydration - resulting in thousands of new cases of kidney stones every year.Mr Bhaskar Somani, a consultant urological surgeon at Southampton General Hospital, said a lack of awareness around regular daily fluid intake was responsible for an annual increase in renal stone admissions.
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** VASCULAR News **
News From The Annals Of Internal Medicine: June 4, 2013
http://mnt.to/a/4dSp
1. Daily Sunscreen Use Slows Skin Aging - Even in Middle-AgeFor the first time, science proves that daily sunscreen use significantly slows skin aging, even in middle-aged men and women. Sunscreen and antioxidants have long been advocated to prevent skin aging, but to date, there has been no scientific evidence of their effectiveness.
Revascularization Procedures Saving Limbs Of More Peripheral Arterial Disease Patients
http://mnt.to/a/4dR6
Peripheral arterial disease is a common circulation problem in which reduced blood flow can lead to complications that jeopardize the limbs, possibly even requiring amputation. Procedures known as have reduced the need for amputations 40 percent over two decades, Mayo Clinic research shows.
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** WATER - AIR QUALITY / AGRICULTURE News **
Higher-Producing, Better-Tasting Chocolate Likely Following Genome Sequencing Of Cacao Plant
http://mnt.to/a/4dRT
The freshly sequenced genome of the most commonly cultivated cacao plant in the world is revealed in the open access journal Genome Biology. Researchers have utilised high quality DNA sequences to demonstrate the usefulness and quality of the sequence to identify genetic markers that can lead to higher yielding cocoa plants that still produce better tasting cocoa.
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** WOMEN'S HEALTH / GYNECOLOGY News **
Europe In 2010: Concern Over The Health And Care Of Pregnant Women And Babies
http://mnt.to/a/4dRh
The burden of mortality and morbidity in the perinatal period - pregnancy, childbirth, and the postpartum - remains a major concern in Europe. Over 5 million women deliver babies in European countries every year.
Reduction In Child Mortality And Improvements In Maternal Health
http://mnt.to/a/4dRg
Rapid expansion of programs to prevent HIV transmission to babies and vaccinate children show how results can be achieved in relatively little timeSome of the world's poorest countries have managed to cut maternal and young child mortality rates by half or more, according to a new report from Countdown to 2015.
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