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Scientists Discover a Better Way to Make Unnatural Amino Acids

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At The Scripps Research Institute (TSRI), chemists have devised a greatly improved technique for making amino acids not found in nature. These "unnatural" amino acids traditionally have been very difficult to synthesize, but are sought after by the pharmaceutical industry for their potential medical uses. "This new technique offers a very quick way to prepare unnatural amino acids, many of which are drug candidates or building blocks for peptide drugs," ...

Forgetting is Actively Regulated in Our Brain

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The human brain requires the ability not only to store but also to forget in order to function properly: Through memory loss, unnecessary information is deleted and the nervous system retains its plasticity. A disruption of this process can lead to serious mental disorders. Basel scientists have now discovered a molecular mechanism that actively regulates the process of forgetting. The renowned scientific journal "iCell/i" has published their results. The ...

Water may Not Aid Weight Loss

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There is no enough evidence that shows drinking lots of water will aid in weight loss, says a researcher. Beth Kitchin, Ph.D., R.D., assistant professor of nutrition sciences, said that there is very little evidence that drinking water promotes weight loss; it is one of those self-perpetuating myths. Kitchin said that another water myth is the consumption rule: eight 8-ounce glasses of water per day. A final water myth Kitchin wants ...

Saudi MERS Death Toll Rises to 63, Report Sources

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Death toll from the MERS coronavirus in the worst-hit country to 63, report Saudi health authorities. The 19-year-old national, who died in Riyadh, had been suffering from chronic illnesses, the health ministry said. Four other people began suffering from the Middle East Respiratory Syndrome after coming into contact with infected people, the ministry said. Among them were two women, aged 18 and 22. That brought the total number of cases ...

Angry People Really Do 'See Red'

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Angry people really do "see red" where others don't, reveals new research. The study examined humankind's ancient association of the colour red with anger, aggression and danger, and the researchers found that, when shown images that were neither fully red nor fully blue, people with hostile personalities were likelier to see red, the Independent reported. According to the scientists, the connection could be linked to humans' evolution from ancestral ...

'Fatty Folds' of the Body Could Fight Kidney Failure!

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When fused to diseased kidneys, the fatty tissue of the abdomen, which is a rich source of stem cells, could help prevent kidney failure, a new study found. The findings, which appear in an upcoming issue of thei Journal of the American Society of Nephrology/i (JASN), suggest that stem cells from within a chronic kidney disease patient''s own abdomen could be used to preserve and possibly improve kidney function. Although adult stem cells have shown promise ...

Fungal Yeast may Help Prevent Thrush!

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A beneficial fungal yeast iPichia/i could actually prevent the growth of iCandida/i, a new study has recently found. i Candida/i is the culprit in oral candidiasis, a painful mouth infection known as thrush. The hope for this finding is that components in iPichia/i could one day become therapeutic agents to stave off not only thrush, but also other life-threatening systemic fungal infections. Research findings about the effect of oral iPichia/i on iCandida/i ...

Scientists Find New Way to Save Brain Cells After Stroke

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A major reduction in disability after a stroke has been observed after using a compound to block the body's immune response. The study by scientists from the University of Wisconsin School of Medicine and Public Health also showed that particular immune cells - CD4+ T-cells produce a mediator, called interleukin (IL) -21 that can cause further damage in stroke tissue. Moreover, normal mice, ordinarily killed or disabled by an ischemic stroke, were given a shot of ...

New Reversible Mechanism to Increase Muscle Elasticity Discovered

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How exactly does yoga improve flexibility? In the Mar 13 cover story of iCell/i, Columbia University biological sciences professor Julio Fernandez and team report the discovery of a new form of mechanical memory that adjusts the elasticity of muscles to their history of stretching. Using highly sensitive atomic force microscopes, the researchers detected a chemical reaction that increases the elasticity of muscle proteins. Crucially, this reaction targets molecules ...

Oxygen Deficiency Linked to Brain Damage

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Lack of oxygen could cause brain damage in conditions like stroke and Alzheimer's disease, a new study found. The discovery, published today in iNeuron/i, brings researchers a step closer to finding potential targets to treat neurodegenerative disorders. Chronic inflammation and hypoxia, or oxygen deficiency, are hallmarks of several brain diseases, but little was known about how they contribute to symptoms such as memory loss. The study ...

Large Waist Could Spell Poor Health, BMI Doesn't Count

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Despite a healthy body mass, having a big belly could have detrimental impacts on health. It's detrimental to your health, even if you have a healthy body mass index (BMI), a new international collaborative study led by a Mayo Clinic researcher found. Men and women with large waist circumferences were more likely to die younger, and were more likely to die from illnesses such as heart disease, respiratory problems, and cancer after accounting for body mass index, ...

Nail Biting Could Actually be Fatal!

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Nail biting could actually cause septic infection and may even lead to death- John Gardner, a British man, seems to have the same fate. John Gardener had contracted a septic infection because of his habit and died while he was recuperating from a surgery to remove the tip of a finger, Metro.co.uk reported. Gardener's doctor said that the former amateur football referee's fingernails were always in a 'bad condition' and he had lost a lot of sensation ...

Diabetes Ups Pancreatic Cancer Risk

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A link between diabetes and pancreatic cancer has been discovered by scientists. "The study revealed the risk of pancreatic cancer was greatest after the diagnosis of diabetes but remained elevated long after the diagnosis," said Mehrdad Nikfarjam, liver, pancreas and biliary specialist at the University of Melbourne. "The presence of diabetes remains a modest risk factor for the development of a cancer later in life," he said. A team ...

Cancer Patients With Insulin-Treated Diabetes Have 4 Times Higher Mortality Rate

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People who have diabetes at the time they are diagnosed with cancer are more likely to die early than those without diabetes. This was concluded by a research published in iDiabetologia/i (the journal of the European Association for the Study of Diabetes). The research is by Kristina Ranc, University of Copenhagen and Steno Diabetes Center, Gentofte, Denmark, and colleagues. The researchers conclude that patients with both diabetes and cancer constitute a particularly ...

Ferrari to Open 100-Million-Euro Amusement Park in Spain

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Ferrari, the Italian luxury sports car maker announced that it will open a 100-million-euro ( (Dollar) 139 million) amusement park in 2016 with rides and a five-star hotel in Spain, its first such venture in Europe. Spread over 75,000 square metres (800,000 square feet) within the PortAventura resort near Barcelona, Ferrari Land will feature Europe's highest and fastest "vertical accelerator", a driving simulator, restaurants, and a 250-room five-star hotel, it said. Ferrari, ...

Michael Schumacher's Family Says F1 Legend Showing Small, Encouraging Signs

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Formula One legend Michael Schumacher's family has revealed that the comatose former racer as been showing 'small, encouraging signs' in his fight for recovery. Doctors in France have been working to bring the seven-time German champion out of a medically induced coma after he suffered a severe head injury in a skiing accident in the French Alps on December 29. According to the BBC, Schumacher's manager Sabine Kehm released a statement on behalf of ...

Facebook Feelings are Contagious: Study

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You can't catch a cold from a friend online. But can you catch a mood? It would seem so, suggests new research from the University of California, San Diego. Published in iPLOS ONE/i, the study analyzes over a billion anonymized status updates among more than 100 million users of Facebook in the United States. Positive posts beget positive posts, the study finds, and negative posts beget negative ones, with the positive posts being more influential, or more ...

Crohn's Disease Patients Show Imbalance in Intestinal Microbial Population

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A multi-institutional study has identified how the intestinal microbial population of newly diagnosed Crohn's disease patients differs from that of individuals free of inflammatory bowel disease (IBD). The study was led by investigators from Massachusetts General Hospital (MGH) and the Broad Institute. In their paper in the March 12 issue of iCell Host and Microbe/i, the researchers report that Crohn's patients showed increased levels of harmful bacteria and ...

PD-L1 Plays an Important Role in the Pathogenesis of Multiple Sclerosis

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Experimental allergic encephalomyelitis is a mouse model of human multiple sclerosis with similar pathogenesis and pathology. Th1 cells play an important role in the pathogenesis of experimental allergic encephalomyelitis. Therefore, Qun Xue, Fanli Dong and co-workers from the First Affiliated Hospital of Soochow University in China speculated that programmed cell death 1 ligand 1 (PD-L1) plays an important role in the pathogenesis of multiple sclerosis. A ...

Peripheral Nerve Regeneration Using Fibrin Glue Membrane

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Following peripheral nerve damage, complete regeneration is usually very difficult, though microsurgical techniques have vastly increased the success rate of surgery to repair the injured nerve. This occurs possibly because of a lack of neurotrophic factors and extracellular matrix in the injured region, which results in a microenvironment that is not optimal for peripheral nerve regeneration. Nerve growth factor (NGF) was the first neurotrophic factor identified ...

Cytotoxicity is a Risk Factor for Diabetic Peripheral Neuropathy

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Iron overload can lead to cytotoxicity, which in turn is a risk factor for diabetic peripheral neuropathy. However, the underlying mechanism remains unclear. Prof. Shi Zhao and team conjectured that iron overload-induced neurotoxicity might be associated with oxidative stress and the NF-E2-related factor 2 (Nrf2)/ARE signaling pathway. As an in vitro cellular model of diabetic peripheral neuropathy, PC12 cells exposed to high glucose concentration were ...

Beauty Treatments can be Injurious to Health: Research

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Despite maintaining the highest levels of hygiene during cosmetic surgery, customers experience unpleasant side effects in the form of tender subcutaneous lumps that are difficult to treat. In isolated cases these complications also lead to lesions that simply will not heal. Injections of fillers were previously reserved exclusively for trauma treatment - when rebuilding a face disfigured in a traffic accident, for example. However, the ...

New Drug to Stop Heart Attack With No Side Effects

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Researchers at the Monash University are a step closer to creating a new drug to stop a heart attack in its tracks and reduce the damage caused, without any side effects. The research offers new hope to thousands of people who experience heart attacks and heart failure - one of the major causes of death worldwide. Professors Arthur Christopoulos and Peter Scammells from the Monash Institute of Pharmaceutical Sciences (MIPS) led a team of scientists ...