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Reintroducing Aprotinin in Cardiac Surgery is Risky for Patients

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Health Canada and European Medicines Agency have decided to reintroduce the use of aprotinin after its withdrawal from the worldwide market in 2007. However, this puts the cardiac surgery patients at risk.The authors of a previous major trial that found a substantially increased risk of death associated with the drug. In an analysis in emCMAJ (Canadian Medical Association Journal/em), the authors refute three major criticisms of the trial made by the regulatory bodies. ...

Fear of Arrest and Abuse in Malaysian Transgenders

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Malaysian Islamic-purity enforcers burst in as Aryana was just returning to her home one night in June, ransacked her apartment and arrested her for cross-dressing. Using a pseudonym to protect her identity, Aryana is transgender -- born a man but identifying as a woman -- and part of a substantial community that complains of rising persecution in the Muslim-majority Southeast Asian country. The 30 year-old was detained for several hours, during which ...

Dialysis for Kidney Injury After Cardiac Surgery

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Infusion with the antihypertensive agent fenoldopam does not reduce the need for dialysis or risk of death at 30 days, among patients with acute kidney injury after cardiac surgery, compared to placebo. But the drug was found to be associated with an increased rate of abnormally low blood pressure, reports a study published in iJAMA/i. The study is being posted early online to coincide with its presentation at the European Society of Intensive Care Medicine ...

Life Extended in Advance Melanoma Patients With Targeted Combination Therapy

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Major declines in the risk of disease progression and death in people with metastatic melanoma was reported as the effect of a targeted combination drug therapy. A world-first study in today's iNew England Journal of Medicine/i heralds the efficacy of this targeted combination drug therapy. The multi-centre, double-blind, randomized, phase 3 trial compared oral dabrafenib (150 mg twice daily) and oral trametinib (2 mg once daily) combination therapy with oral ...

'Hibernator'- Breakfast Packed With 8K Calories Makes You Sleep For A Year

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A beastly breakfast packed with 8,000 calories has been created by a Brit Chef, which he claims can put the person eating it to sleep. Mark Winder of the Bear Grills Cafe in Congleton, Cheshire, has made a breakfast that includes eight rashers of bacon, eight sausages, four hash browns, four fried eggs, a four-egg cheese omelette, four waffles, four pieces of toast, four pieces of fried bread, four black pudding, two ladles of beans, two ladles of tomatoes, mushrooms, ...

Shining Cells Responsible for Developing Tumors Discovered

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A new specific marker for cancer stem cells: riboflavin, or vitamin B2, a pigment that emits green fluorescence as a result of its accumulation inside intracellular vesicles has been discovered by Spanish National Cancer Research Centre researchers. Results from the research, headed by scientists Irene Miranda, Bruno Sainz and Christopher Heeschen, are published today in the journal iNature Methods/i. "The discovery of this new marker is a breakthrough, ...

Characterization of Molecular Mechanism Involved in Cellular Proliferation

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The molecular interaction between TACC3 and chTOG has been uncovered. These are the key proteins in forming the internal cellular framework that enables and sustains cell division. This study was done by researchers from Guillermo Montoya's team at the Spanish National Cancer Research Centre (CNIO), in collaboration with Isabelle Vernos' Group from the Centre for Genomic Regulation (CRG). Published today in iNature Communications/i, the observations may help to optimize ...

Standard Care for HER2-Positive Breast Cancer: Trastuzumab

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Trastuzumab, Herceptin, should remain the standard of care for HER2-positive breast cancer, says a Mayo Clinic researcher, after analysis of more than 8,000 women with the cancer. These women participated in the world's largest study of two treatments for HER2-positive breast cancer. This study, being presented at the European Society for Medical Oncology (ESMO) 2014 Congress in Madrid, reveals that when used as a single HER2-targeted therapy in addition to standard ...

Targeted Approaches to Certain Lung Cancer Show Promising Results

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After chemotherapy disease progresses in some of the patients with advanced BRAF V600E mutant non-small cell lung cancer. The BRAF inhibitor dabrafenib was found to have significant anti-tumour activity in such patients. Phase II data presented at the ESMO 2014 Congress in Madrid, Spain revealed the results. "Reports of lung cancers bearing mutations in BRAF have generated considerable interest because these mutations may be associated with increased sensitivity ...

Endoscopists Recommend Frequent Colonoscopies, Leading to Its Overuse: Study

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A new research reveals an overuse of colonoscopies for colorectal cancer screening and surveillance. The study demonstrated that endoscopists commonly recommended shorter follow-up intervals than established guidelines support, and these recommendations were strongly correlated with subsequent colonoscopy overuse. "Our study shows that a high percentage of follow-up colonoscopies are being performed too early, resulting in use of scarce health care resources ...

Infections From Intestinal Superbug Doubled in Ten Years

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A study published in the iAmerican Journal of Infection Control/i, revealed that cases of infections with the intestinal superbug IC. difficile/I nearly doubled from 2001 to 2010 in U.S. hospitals without noticeable improvement in patient mortality rates or hospital lengths of stay. This study was carried out on 2.2 million IC. difficile/I infection (CDI) patients. In this retrospective study from The University of Texas College of Pharmacy, researchers ...

Gut Bacteria Promote Obesity

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A new study published in mBio finds iClostridium ramosum/i coupled with a high-fat diet, may cause animals to gain weight. A research team from the German Institute of Human Nutrition Potsdam-Rehbruecke in Nuthetal observed that mice harboring human gut bacteria including IC. ramosum/I gained weight when fed a high-fat diet. Mice that did not have IC. ramosum/I were less obese even when consuming a high-fat diet, and mice that had IC. ramosum/I ...

Finding Paves Way for New Antiviral Therapies

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Viruses that cause infection undergo a change in the DNA structure from rigid crystalline structure into a fluid-like structure. This change in the DNA structure facilitates infection. The findings, published in iNature Chemical Biology/i and the iProceedings of the National Academy of Sciences/i (iPNAS/i), provide a promising new target for antiviral therapies. Most antiviral drugs work by deactivating viral proteins, but viruses often evolve and ...

'Gold of Pleasure' - Oilseed Could Help In Liver Detoxification

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Compounds that boost liver detoxification enzymes nearly fivefold have been found in the most unlikely of places - the crushed seeds left after oil extraction from an oilseed crop used in jet fuel, said scientists at University of Illinois. "The bioactive compounds in iCamelina sativa/i seed, also known as Gold of Pleasure, are a mixture of phytochemicals that work together synergistically far better than they do alone. The seed meal is a promising nutritional ...

US Soldiers Return Home With Traumatic Brain Injuries

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Over 300,000 soldiers have returned to the United States post military conflicts in Iraq and Afghanistan, with traumatic brain injuries caused by exposure to bomb blasts and improvised explosive devices(IEDs). Mild, lingering headaches and nausea or even more severe impairments in memory and cognition are symptoms of such traumatic brain injuries. Since 2007, the U.S. Department of Defense has recognized the critical importance and complexity of this problem, and ...

Fatty Liver Disease: A Growing Health Problem in India

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Non alcoholic fatty liver disease (NAFLD) is the leading cause of liver dysfunction worldwide and is a rapidly growing health problem in India.

Almond Milk - Properties and Benefits

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What is almond milk? Is almond milk good for you? This plant based alternative to dairy milk has health benefits aside from alleviating symptoms of lactose intolerance, which will be discussed in this article.

Key Component In Household Vinegar Could Treat Anemia

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Researchers at UT Southwestern Medical Center have found that giving acetate, a key component in household vinegar, to anemic mice stimulated the formation of new red blood cells. The study sought novel ways to treat anemia. Currently, the hormone erythropoietin is administered to treat anemia, but this treatment carries with it side effects such as a href="http:www.utswmedicine.org/conditions-specialties/heart/programs/general/high-blood-pressure/" target="_blank"hypertension/a ...

Ice Storm Babies Show DNA Signature

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Epigentic profile of a child born after the Quebec's Ice Storm (1998) could be predicted by the number of days an expectant mother was deprived of electricity during the storm, finds a new study. Scientists from the Douglas Mental Health University Institute and McGill University have detected a distinctive 'signature' in the DNA of children born in the aftermath of the massive Quebec ice storm. Five months after the event, researchers recruited women who had been ...

Administering Antibiotics Before Age Two Could Cause Obesity in Children

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A new study in the US said that children who are treated with a wide range of antibiotics before they are two years old are at higher risk of childhood obesity. The research in the Journal of the American Medical Association (JAMA) Pediatrics is the latest to find a link between weight problems and antibiotics, which can eliminate bacterial infections but also the beneficial intestinal microflora that colonizes the gut. Experts at the Children's Hospital ...

Sudden Transformation of a 2-Month-Old into a Grown Man

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In Foquelleh, Panta district of Bong County, Liberia, a 2-month-old baby suddenly grew into a full grown man. He was on his way to farm with his mother when this happened. The mother of the child, Lorpu Kollie, told the Daily Observer that her baby spoke to her and asked her to put him down and as soon as she put the baby down, the two-month-old boy instantaneously began to grow into a full grown man. The 16-year-old mother continued that ...

Conservative Men Preferred by Rich Spinsters

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Rich single women are found to prefer men who are conservative rather than those who are liberals, in a new study. The survey conducted by an online dating service MillionaireMatch.com showed that found that millionaire singles of both sexes were more attracted to conservatives than liberals, Washington Times reported. According to the study, 40percent of single women verified as millionaires surveyed said that they preferred to be matched ...

'Weed' Should Not be Used by Teens

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Marijuana is thought to be a harmless drug by the public, but research shows that it can have a damaging effect on developing brains and may lead to a life long addiction. In a new study scientists have given reasons why marijuana can be harmful for teenagers. Whether states should legalize marijuana for recreational and medical use is a hot topic across the country. As the debates continue a potentially dangerous environment is being created where ...

Polio Vaccination to be Given to Over 33 Million Pak Kids

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Polio vaccine will be administered for over 33 million children in Pakistan from Monday through Thursday. The Dawn reports that a majority of the 7.6 million children in the country's Sindh Province will be inoculated against polio during the four-day campaign beginning on Monday. Dr. Zafar Ijaz, Director (Health) for the Karachi division, said arrangements to provide security to more than 6,000 teams in Karachi have been taken. Stringent ...

New Findings on Treatment Options for Mesothelioma

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Treating patients with high-dose radiotherapy after chemotherapy and surgery for malignant pleural mesothelioma does not achieve improvements in local relapse and overall survival. This is according to data from a prospective randomized phase II trial presented at ESMO 2014 Congress in Madrid. "Mesothelioma remains a difficult disease to find better treatment options for, so we asked whether high-dose hemithoracic radiotherapy would decrease the rate ...