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** ALCOHOL / ADDICTION / ILLEGAL DRUGS News **
First analysis of global drug dependence reveals opioids responsible for the greatest burden of death and illness
http://mnt.to/a/4gxc
The first ever analysis of the global and regional prevalence of dependence upon the four major categories of illicit drugs - amphetamine, cannabis, cocaine, and opioids (such as heroin) - has revealed that opioid dependence causes the greatest health burden (overall death and illness) of all the illicit drugs.
Cannabis and the adolescent brain: Perception as a 'safe drug' is scientifically inaccurate
http://mnt.to/a/4gw5
The nature of the teenage brain makes users of cannabis amongst this population particularly at risk of developing addictive behaviors and suffering other long-term negative effects, according to researchers at the University of Montreal and New York's Icahn School of Medicine at Mount Sinai.
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** ALZHEIMER'S / DEMENTIA News **
Genome-wide survey examines recessive alzheimer disease gene
http://mnt.to/a/4gxH
Runs of homozygosity (ROHs, regions of the genome where the copies inherited from parents are identical) may contribute to the etiology (origin) of Alzheimer disease (AD), according to a study by Mahdi Ghani, Ph.
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** ANXIETY / STRESS News **
Math anxiety experienced by girls
http://mnt.to/a/4gwK
Girls report more math anxiety on general survey measures but are not actually more anxious during math classes and exams, according to new research forthcoming in Psychological Science, a journal of the Association for Psychological Science.
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** BACK PAIN News **
Spinal compression fractures - a common cause of back pain
http://mnt.to/a/4gxC
Spinal compression fractures are an often overlooked, but common cause of back pain. These small fractures in the bones that form your spine are frequently caused by osteoporosis. Fortunately, spinal compression fractures can be treated with pain medicine and bed rest.
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** BIOLOGY / BIOCHEMISTRY News **
Special challenges and opportunities of cyanobacteria for the emerging field of synthetic biology
http://mnt.to/a/4gxy
Development of a redesigned strain of light-harvesting cyanobacteria is a realistic goal that will have many applications in biotechnology, reports a review in Frontiers in Microbiology.The emerging field of synthetic biology has already successfully used genes from naturally occurring organisms to build safe and nonpolluting strains of microbes that can take photographs or produce antimalarial drugs.
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** BLOOD / HEMATOLOGY News **
Genomic sequencing leads to discovery of origin of hereditary east Texas bleeding disorder
http://mnt.to/a/4gwB
A severe hereditary bleeding disorder was described in a large family from east Texas in 2001. The affected family members routinely had bruising, nosebleeds, massive blood loss following injury or surgery, and often required blood transfusions.
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** BONES / ORTHOPEDICS News **
Spinal compression fractures - a common cause of back pain
http://mnt.to/a/4gxC
Spinal compression fractures are an often overlooked, but common cause of back pain. These small fractures in the bones that form your spine are frequently caused by osteoporosis. Fortunately, spinal compression fractures can be treated with pain medicine and bed rest.
Best practice standards for coordinator-based fracture liaison services
http://mnt.to/a/4gwP
Implementation of effective coordinator-based FLS services worldwide can reduce treatment gap by ensuring that fracture patients are identified and treated to reduce future fracture riskAn influential report published in the journal 'Osteoporosis International', recommends 13 best practice standards in the implementation of coordinator-based fracture liaison services (FLS).
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** BREAST CANCER News **
What is a breast biopsy?
http://mnt.to/a/4gzf
A breast biopsy is the surgical removal of a small sample of breast tissue or cells to be tested for breast cancer. The doctor may recommend a biopsy if the patient has an abnormal mammogram or a lump in the breast.
Terminology used to describe preinvasive breast cancer may affect patients' treatment preferences
http://mnt.to/a/4gxD
When ductal carcinoma in situ (DCIS, a preinvasive malignancy of the breast) is described as a high-risk condition rather than cancer, more women report that they would opt for nonsurgical treatments, according to a research letter by Zehra B.
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** CANCER / ONCOLOGY News **
Study suggests thyroid ultrasound imaging may be useful to reduce biopsies in patients with low risk of cancer
http://mnt.to/a/4gxF
Thyroid ultrasound imaging could be used to identify patients who have a low risk of cancer for whom biopsy could be postponed, according to a study by Rebecca Smith-Bindman, M.D., of the University of California, San Francisco, and colleagues.
Some stem cells are more susceptible to cancer than others
http://mnt.to/a/4gx6
Cells in the body wear down over time and die. In many organs, like the small intestine, adult stem cells play a vital role in maintaining function by replacing old cells with new ones. Learning about the nature of tissue stem cells can help scientists understand exactly how our organs are built, and why some organs generate cancer frequently, but others only rarely.
Microarray-based gene expression profiling reveals 3 subtypes of gastric cancer
http://mnt.to/a/4gx4
Stomach cancer, one of the leading causes of cancer death worldwide, actually falls into three broad subtypes that respond differently to currently available therapies, according to researchers at Duke-NUS Graduate Medical School Singapore.
Zealous imaging is fuelling unnecessary and harmful treatment of low risk thyroid cancers, warn experts
http://mnt.to/a/4gwY
New imaging techniques are fuelling an epidemic in diagnosis and treatment of thyroid cancers that are unlikely to ever progress to cause symptoms or death, warn experts on bmj.com.New technologies such as ultrasound, CT and MRI scanning can detect thyroid nodules as small as 2mm - many of these small nodules are papillary thyroid cancers.
Combating drug-resistant cancers
http://mnt.to/a/4gwD
Many cancer therapies function by activating proteins like Caspase-3 (CASP3) that promote cell death. Several forms of cancer develop resistance to these drugs by down regulating CASP3 through an unknown mechanism.
Software tool developed for cancer genomics
http://mnt.to/a/4gwh
Researchers at the Medical College of Wisconsin (MCW) have developed a new bioinformatics software tool designed to more easily identify genetic mutations responsible for cancers. The tool, called DrGaP, is the subject of a new paper published in the American Journal of Human Genetics.
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** CARDIOVASCULAR / CARDIOLOGY News **
Personalised management of atrial fibrillation in the future will reduce the associated excess mortality
http://mnt.to/a/4gwm
Personalised management is the only way to close the mortality gap for patients with atrial fibrillation (AF), according to an ESC consensus paper presented at ESC Congress 2013 by Professor Paulus Kirchhof (UK).
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** CERVICAL CANCER / HPV VACCINE News **
African-American women less likely to receive HPV vaccine than whites, even with access to health care, Pitt study finds
http://mnt.to/a/4gxw
Even with access to health care, African-American women are less likely to receive the vaccine for human papillomavirus (HPV), which reduces the risk for cervical cancer, according to a study by researchers at the University of Pittsburgh School of Medicine.
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** CHOLESTEROL News **
Heart disease risk reduced by early diabetes interventions
http://mnt.to/a/4gwT
Two treatments that slow the development of diabetes also may protect people from heart disease, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).
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** CLINICAL TRIALS / DRUG TRIALS News **
Boston Children's launches Phase I clinical trial of long-lasting local anesthetic derived from cyanobacteria
http://mnt.to/a/4gxz
Boston Children's Hospital has received Investigational New Drug (IND) approval from the US Food and Drug Administration (FDA) for neosaxitoxin, a new local anesthetic derived from cyanobacteria being developed in partnership with Proteus SA, of Santiago, Chile.
New treatments better than standard ones just over half the time
http://mnt.to/a/4gx3
USF Distinguished Professor Benjamin Djulbegovic, MD, PhD, has studied the ethics of randomized clinical trials and their effectiveness in evaluating the outcomes of new treatments for decades.
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** COLORECTAL CANCER News **
For colorectal cancer patients at VA, wait times up 78 percent
http://mnt.to/a/4gwf
A study published in the August print issue of the Journal of Oncology Practice shows that from 1998-2008, wait times for colorectal cancer operations at Veterans Administration hospitals increased from 19 to 32 days.
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** CROHN'S / IBD News **
New report shows improvement for patients with IBD following biological therapy
http://mnt.to/a/4gx5
Over half of patients saw an improvement after being treated with biological therapies for inflammatory bowel disease (IBD). Data from the first national report of biological therapies shows that 62% of adult patients and 73% of paediatric patients saw the severity of their disease decrease after 12 weeks of treatment with biological therapy.
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** DEPRESSION News **
Mental and substance use disorders 'leading cause of non-fatal illness'
http://mnt.to/a/4gyp
Researchers say that combined, mental and substance use disorders were the leading cause of non-fatal illness worldwide in 2010, according to a study published in the The Lancet.The study, conducted by researchers from Australia and the US, analyzed data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2010 (GBD 2010).
Depression affects men just as much as women
http://mnt.to/a/4gxv
Around the world, women are typically diagnosed with depression twice as often as men. But a recent study published in JAMA Psychiatry looks at these disparities in a new way by considering alternative symptoms of depression typically attributed to men.
A history of depression increases risk for future episodes following divorce
http://mnt.to/a/4gwH
Divorce is associated with an increased risk of future depressive episodes but only for those who already have a history of depression, according to a new study published in Clinical Psychological Science, a journal of the Association for Psychological Science.
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** DIABETES News **
What is the hemoglobin A1c test
http://mnt.to/a/4gzd
The hemoglobin A1c test is a common blood test used to determine how well patients are managing their diabetes. It is also called the HbA1c, glycohemoglobin, or glycated hemoglobin test. The test is commonly used to screen for type 1 and 2 diabetes.
Heart disease risk reduced by early diabetes interventions
http://mnt.to/a/4gwT
Two treatments that slow the development of diabetes also may protect people from heart disease, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).
Healthy metabolic status in some obese people likely explained by low inflammation
http://mnt.to/a/4gwS
Reduced levels of inflammation may explain how some obese people are able to remain metabolically healthy, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).
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** EATING DISORDERS News **
Mental and substance use disorders 'leading cause of non-fatal illness'
http://mnt.to/a/4gyp
Researchers say that combined, mental and substance use disorders were the leading cause of non-fatal illness worldwide in 2010, according to a study published in the The Lancet.The study, conducted by researchers from Australia and the US, analyzed data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2010 (GBD 2010).
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** ENDOCRINOLOGY News **
Study suggests thyroid ultrasound imaging may be useful to reduce biopsies in patients with low risk of cancer
http://mnt.to/a/4gxF
Thyroid ultrasound imaging could be used to identify patients who have a low risk of cancer for whom biopsy could be postponed, according to a study by Rebecca Smith-Bindman, M.D., of the University of California, San Francisco, and colleagues.
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** EYE HEALTH / BLINDNESS News **
Scientists discover drug that could combat migraines
http://mnt.to/a/4gwV
Researchers have discovered a new compound that could potentially treat migraines by blocking light sensors in the eyes, according to a study published in the journal Nature Chemical Biology.
Technique from astronomy will change the way eye care professionals think about vision correction
http://mnt.to/a/4gwJ
Techniques developed by astronomers seeking a clear view of objects in space are coming closer to home, as eye care professionals apply the concept of wavefront optics to understanding - and correcting - subtle visual abnormalities of the human eye, according to a special article in the September issue of Optometry and Vision Science*, official journal of the American Academy of Optometry.
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** FLU / COLD / SARS News **
New moms and obese people risk complications from influenza: McMaster study
http://mnt.to/a/4gxx
Although up to 500,000 people world-wide die of severe influenza each year, there has been no clear evidence about who is susceptible for influenza complications and it may not be who people think, says a study from McMaster University.
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** GASTROINTESTINAL / GASTROENTEROLOGY News **
Microarray-based gene expression profiling reveals 3 subtypes of gastric cancer
http://mnt.to/a/4gx4
Stomach cancer, one of the leading causes of cancer death worldwide, actually falls into three broad subtypes that respond differently to currently available therapies, according to researchers at Duke-NUS Graduate Medical School Singapore.
Newly developed testing strategy identifies more Australians at risk for coeliac disease
http://mnt.to/a/4gwQ
Australian researchers have developed a new approach to detecting coeliac disease, revealing this immune disorder is far more common than previously recognised.In a study of more than 2500 Victorians the researchers combined traditional antibody testing (measuring the immune response to gluten) with an assessment of specific genetic risk markers.
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** GENETICS News **
Scientists at Genome Institute of Singapore discover gene that controls the birth of neurons
http://mnt.to/a/4gxK
Scientists at A*STAR's Genome Institute of Singapore (GIS) have discovered an unusual gene that controls the generation of neurons[1]. This important finding, which is crucial in understanding serious diseases of the brain such as Alzheimer's disease, was reported in the 8th August 2013 issue of the prestigious scientific journal, Molecular Cell.
Genome-wide survey examines recessive alzheimer disease gene
http://mnt.to/a/4gxH
Runs of homozygosity (ROHs, regions of the genome where the copies inherited from parents are identical) may contribute to the etiology (origin) of Alzheimer disease (AD), according to a study by Mahdi Ghani, Ph.
Microarray-based gene expression profiling reveals 3 subtypes of gastric cancer
http://mnt.to/a/4gx4
Stomach cancer, one of the leading causes of cancer death worldwide, actually falls into three broad subtypes that respond differently to currently available therapies, according to researchers at Duke-NUS Graduate Medical School Singapore.
Some HIV-infected patients with certain gene at increased risk for fungal disease
http://mnt.to/a/4gwX
HIV-infected people who carry a gene for a specific protein face a 20-fold greater risk of contracting cryptococcal disease, according to a study published in mBio®, the online open-access journal of the American Society for Microbiology.
Prevention of preterm birth caused by gene-environment interactions
http://mnt.to/a/4gwz
New research in the Journal of Clinical Investigation provides evidence that gene-environment interactions are a major contributor to preterm birth and that using a combinatory treatment strategy can prevent preterm delivery in a mouse model.
The molecular process behind a form of non-syndromic deafness
http://mnt.to/a/4gwx
Researchers identify an underlying molecular process that causes a genetic form of non-syndromic deafness in a new study that also suggests affected families may be at risk of damage to other organs.
Software tool developed for cancer genomics
http://mnt.to/a/4gwh
Researchers at the Medical College of Wisconsin (MCW) have developed a new bioinformatics software tool designed to more easily identify genetic mutations responsible for cancers. The tool, called DrGaP, is the subject of a new paper published in the American Journal of Human Genetics.
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** HEADACHE / MIGRAINE News **
Migraines can alter brain structure permanently
http://mnt.to/a/4gxd
Scientists have discovered that migraines may affect the long-term structure of the brain and increase the risk of brain lesions, according to a study published in the journal Neurology.Researchers from the University of Copenhagen in Denmark analyzed six population-based studies and 13 clinic-based studies to see whether there was a link between migraines and brain lesions, silent abnormalities or brain volume changes.
Scientists discover drug that could combat migraines
http://mnt.to/a/4gwV
Researchers have discovered a new compound that could potentially treat migraines by blocking light sensors in the eyes, according to a study published in the journal Nature Chemical Biology.
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** HEARING / DEAFNESS News **
The molecular process behind a form of non-syndromic deafness
http://mnt.to/a/4gwx
Researchers identify an underlying molecular process that causes a genetic form of non-syndromic deafness in a new study that also suggests affected families may be at risk of damage to other organs.
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** HEART DISEASE News **
Wireless fitness monitor 'can help heart surgery recovery'
http://mnt.to/a/4gxL
A simple wireless "off-the-shelf" fitness monitor could help the recovery of patients who have had heart surgery, according to a study to be published in The Annals of Thoracic Surgery.Researchers from the Mayo Clinic in Rochester, MN, analyzed a number of patients over the age of 50 who had undergone elective heart surgery.
Heart disease risk reduced by early diabetes interventions
http://mnt.to/a/4gwT
Two treatments that slow the development of diabetes also may protect people from heart disease, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).
----------------------------------------------
** HIV / AIDS News **
Some HIV-infected patients with certain gene at increased risk for fungal disease
http://mnt.to/a/4gwX
HIV-infected people who carry a gene for a specific protein face a 20-fold greater risk of contracting cryptococcal disease, according to a study published in mBio®, the online open-access journal of the American Society for Microbiology.
It is essential to treat pediatric AIDS in the elimination agenda
http://mnt.to/a/4gwG
Scott Kellerman and colleagues argue that the scope of the current HIV elimination agenda must be broadened in order to ensure access to care and treatment for all children living with HIV.In 2011, despite the global initiative to eliminate mother-to-child transmission of HIV, 330,000 new pediatric infections were added worldwide to the existing pool of 3.
Multiple stages of the HIV-1 life cycle involved in protease inhibitor resistance
http://mnt.to/a/4gwC
HIV-1 protease inhibitors are very effective antiviral drugs. These drugs target HIV-1 proteases, which are required for viral replication. Despite the success of protease inhibitors for suppressing HIV-1, some patients do not respond to protease inhibitor therapy.
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** IMMUNE SYSTEM / VACCINES News **
Healthy metabolic status in some obese people likely explained by low inflammation
http://mnt.to/a/4gwS
Reduced levels of inflammation may explain how some obese people are able to remain metabolically healthy, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).
Newly developed testing strategy identifies more Australians at risk for coeliac disease
http://mnt.to/a/4gwQ
Australian researchers have developed a new approach to detecting coeliac disease, revealing this immune disorder is far more common than previously recognised.In a study of more than 2500 Victorians the researchers combined traditional antibody testing (measuring the immune response to gluten) with an assessment of specific genetic risk markers.
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** INFECTIOUS DISEASES / BACTERIA / VIRUSES News **
Shedding light on the origin and evolution of reticuloendotheliosis viruses
http://mnt.to/a/4gx2
A new study by Anna Maria Niewiadomska and Robert Gifford, of The Aaron Diamond AIDS Research Center, New York, reveals that reticuloendotheliosis viruses (REVs), which originated in mammals, spread to birds as a result of medical intervention.
Some HIV-infected patients with certain gene at increased risk for fungal disease
http://mnt.to/a/4gwX
HIV-infected people who carry a gene for a specific protein face a 20-fold greater risk of contracting cryptococcal disease, according to a study published in mBio®, the online open-access journal of the American Society for Microbiology.
Non-invasive transcranial direct current stimulation improves sleep in patients with post-polio syndrome
http://mnt.to/a/4gwd
Of the 15 million people around the world who have survived poliomyelitis, up to 80% report progressive deteriorating strength and endurance many years after infection, a condition known as post-polio syndrome (PPS).
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** LYMPHOMA / LEUKEMIA / MYELOMA News **
Halting the development of leukemia cells, demonstrating the potential viability of RUNX1 as a therapeutic target
http://mnt.to/a/4gwy
New research in the Journal of Clinical Investigation suggests that blocking a protein normally credited with suppressing leukemia may be a promising therapeutic strategy for an aggressive form of the disease called acute myeloid leukemia (AML).
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** MEDICAL DEVICES / DIAGNOSTICS News **
Kidney stone removal breakthrough combines robotic surgery with new cooling technique
http://mnt.to/a/4gwN
A first-ever technique using ice slush and minimally invasive robotic surgery to remove a particularly large type of kidney stone has been reported by urologists at Henry Ford Hospital.Dubbed RANL, for robotic anatrophic nephrolithotomy, the technique was devised to remove staghorn calculi - large kidney stones with sharp, craggy branches - that can cause disease and sometimes death if left untreated.
Technique from astronomy will change the way eye care professionals think about vision correction
http://mnt.to/a/4gwJ
Techniques developed by astronomers seeking a clear view of objects in space are coming closer to home, as eye care professionals apply the concept of wavefront optics to understanding - and correcting - subtle visual abnormalities of the human eye, according to a special article in the September issue of Optometry and Vision Science*, official journal of the American Academy of Optometry.
Software tool developed for cancer genomics
http://mnt.to/a/4gwh
Researchers at the Medical College of Wisconsin (MCW) have developed a new bioinformatics software tool designed to more easily identify genetic mutations responsible for cancers. The tool, called DrGaP, is the subject of a new paper published in the American Journal of Human Genetics.
----------------------------------------------
** MELANOMA / SKIN CANCER News **
Skin cancer an increased risk for recipients of donor kidneys
http://mnt.to/a/4gwF
Patients that receive kidney transplants have an increased risk of an invasive form of skin cancer. It is unclear if donor tissue contributes to cancer formation. In this issue of the Journal of Clinical Investigation, Philippe Ratajczak and colleagues at INSERM demonstrate that donor tissue can lead to cancer formation in transplant recipients.
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** MENTAL HEALTH News **
Mental and substance use disorders 'leading cause of non-fatal illness'
http://mnt.to/a/4gyp
Researchers say that combined, mental and substance use disorders were the leading cause of non-fatal illness worldwide in 2010, according to a study published in the The Lancet.The study, conducted by researchers from Australia and the US, analyzed data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2010 (GBD 2010).
Depression affects men just as much as women
http://mnt.to/a/4gxv
Around the world, women are typically diagnosed with depression twice as often as men. But a recent study published in JAMA Psychiatry looks at these disparities in a new way by considering alternative symptoms of depression typically attributed to men.
----------------------------------------------
** MRI / PET / ULTRASOUND News **
Study suggests thyroid ultrasound imaging may be useful to reduce biopsies in patients with low risk of cancer
http://mnt.to/a/4gxF
Thyroid ultrasound imaging could be used to identify patients who have a low risk of cancer for whom biopsy could be postponed, according to a study by Rebecca Smith-Bindman, M.D., of the University of California, San Francisco, and colleagues.
Zealous imaging is fuelling unnecessary and harmful treatment of low risk thyroid cancers, warn experts
http://mnt.to/a/4gwY
New imaging techniques are fuelling an epidemic in diagnosis and treatment of thyroid cancers that are unlikely to ever progress to cause symptoms or death, warn experts on bmj.com.New technologies such as ultrasound, CT and MRI scanning can detect thyroid nodules as small as 2mm - many of these small nodules are papillary thyroid cancers.
----------------------------------------------
** MRSA / DRUG RESISTANCE News **
Combating drug-resistant cancers
http://mnt.to/a/4gwD
Many cancer therapies function by activating proteins like Caspase-3 (CASP3) that promote cell death. Several forms of cancer develop resistance to these drugs by down regulating CASP3 through an unknown mechanism.
----------------------------------------------
** NEUROLOGY / NEUROSCIENCE News **
Parkinson's severity linked to brain inflammation
http://mnt.to/a/4gxT
A new study found markers of inflammation in the cerebrospinal fluid that protects the brain and spine from injury, linking these markers to symptoms like fatigue, depression and anxiety in patients with Parkinson's disease.
Scientists at Genome Institute of Singapore discover gene that controls the birth of neurons
http://mnt.to/a/4gxK
Scientists at A*STAR's Genome Institute of Singapore (GIS) have discovered an unusual gene that controls the generation of neurons[1]. This important finding, which is crucial in understanding serious diseases of the brain such as Alzheimer's disease, was reported in the 8th August 2013 issue of the prestigious scientific journal, Molecular Cell.
Scientists successfully grow 'mini-brains' from stem cells
http://mnt.to/a/4gxB
Scientists have successfully grown complex human brain tissue from stem cells using a new 3D culture system, according to a study published in the journal Nature.Researchers from the Institute of Molecular Biotechnology (IMBA) at the Austrian Academy of Sciences (OeAW) say the newly created tissue could be the start of developing model systems for the human brain.
Migraines can alter brain structure permanently
http://mnt.to/a/4gxd
Scientists have discovered that migraines may affect the long-term structure of the brain and increase the risk of brain lesions, according to a study published in the journal Neurology.Researchers from the University of Copenhagen in Denmark analyzed six population-based studies and 13 clinic-based studies to see whether there was a link between migraines and brain lesions, silent abnormalities or brain volume changes.
Non-invasive transcranial direct current stimulation improves sleep in patients with post-polio syndrome
http://mnt.to/a/4gwd
Of the 15 million people around the world who have survived poliomyelitis, up to 80% report progressive deteriorating strength and endurance many years after infection, a condition known as post-polio syndrome (PPS).
----------------------------------------------
** OBESITY / WEIGHT LOSS / FITNESS News **
New moms and obese people risk complications from influenza: McMaster study
http://mnt.to/a/4gxx
Although up to 500,000 people world-wide die of severe influenza each year, there has been no clear evidence about who is susceptible for influenza complications and it may not be who people think, says a study from McMaster University.
Healthy metabolic status in some obese people likely explained by low inflammation
http://mnt.to/a/4gwS
Reduced levels of inflammation may explain how some obese people are able to remain metabolically healthy, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).
----------------------------------------------
** OVARIAN CANCER News **
Gynecologic surgery patients benefit from enhanced recovery pathway
http://mnt.to/a/4gw9
Patients who had complex gynecologic surgery managed by an enhanced recovery pathway (ERP) resulted in decreased narcotic use, earlier discharge, stable readmission rates, excellent patient satisfaction and cost savings, according to a Mayo Clinic study.
----------------------------------------------
** PAIN / ANESTHETICS News **
Boston Children's launches Phase I clinical trial of long-lasting local anesthetic derived from cyanobacteria
http://mnt.to/a/4gxz
Boston Children's Hospital has received Investigational New Drug (IND) approval from the US Food and Drug Administration (FDA) for neosaxitoxin, a new local anesthetic derived from cyanobacteria being developed in partnership with Proteus SA, of Santiago, Chile.
----------------------------------------------
** PARKINSON'S DISEASE News **
Parkinson's severity linked to brain inflammation
http://mnt.to/a/4gxT
A new study found markers of inflammation in the cerebrospinal fluid that protects the brain and spine from injury, linking these markers to symptoms like fatigue, depression and anxiety in patients with Parkinson's disease.
Study examines cerebrospinal fluid biomarkers in early Parkinson disease
http://mnt.to/a/4gxJ
Cerebrospinal fluid (CSF) levels of tau proteins, a-synuclein, and β-amyloid 1-42 (Aβ1-42) appear to be associated with early stage Parkinson disease (PD) in a group of untreated patients compared with healthy patients, according to a study by Ju-Hee Kang, M.
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** PEDIATRICS / CHILDREN'S HEALTH News **
Excessive screen time affects children's well-being
http://mnt.to/a/4gxP
A sedentary lifestyle with too much time spent sitting in front of screens - such as watching TV, playing video games and surfing the Internet - is harming children's well-being and increasing their anxiety, according to a new briefing paper from Public Health England (PHE).
Interpretation of do-not-resuscitate order appears to vary among pediatric physicians, study suggests
http://mnt.to/a/4gxG
Clinicians use the do-not-resuscitate (DNR) order not only as a guide for therapeutic decisions during a cardiopulmonary arrest but also as a surrogate for broader treatment directives, according to a study by Amy Sanderson M.
Math anxiety experienced by girls
http://mnt.to/a/4gwK
Girls report more math anxiety on general survey measures but are not actually more anxious during math classes and exams, according to new research forthcoming in Psychological Science, a journal of the Association for Psychological Science.
It is essential to treat pediatric AIDS in the elimination agenda
http://mnt.to/a/4gwG
Scott Kellerman and colleagues argue that the scope of the current HIV elimination agenda must be broadened in order to ensure access to care and treatment for all children living with HIV.In 2011, despite the global initiative to eliminate mother-to-child transmission of HIV, 330,000 new pediatric infections were added worldwide to the existing pool of 3.
Cannabis and the adolescent brain: Perception as a 'safe drug' is scientifically inaccurate
http://mnt.to/a/4gw5
The nature of the teenage brain makes users of cannabis amongst this population particularly at risk of developing addictive behaviors and suffering other long-term negative effects, according to researchers at the University of Montreal and New York's Icahn School of Medicine at Mount Sinai.
----------------------------------------------
** PHARMA INDUSTRY / BIOTECH INDUSTRY News **
Special challenges and opportunities of cyanobacteria for the emerging field of synthetic biology
http://mnt.to/a/4gxy
Development of a redesigned strain of light-harvesting cyanobacteria is a realistic goal that will have many applications in biotechnology, reports a review in Frontiers in Microbiology.The emerging field of synthetic biology has already successfully used genes from naturally occurring organisms to build safe and nonpolluting strains of microbes that can take photographs or produce antimalarial drugs.
New treatments better than standard ones just over half the time
http://mnt.to/a/4gx3
USF Distinguished Professor Benjamin Djulbegovic, MD, PhD, has studied the ethics of randomized clinical trials and their effectiveness in evaluating the outcomes of new treatments for decades.
----------------------------------------------
** PREGNANCY / OBSTETRICS News **
Prevention of preterm birth caused by gene-environment interactions
http://mnt.to/a/4gwz
New research in the Journal of Clinical Investigation provides evidence that gene-environment interactions are a major contributor to preterm birth and that using a combinatory treatment strategy can prevent preterm delivery in a mouse model.
----------------------------------------------
** PRIMARY CARE / GENERAL PRACTICE News **
Interpretation of do-not-resuscitate order appears to vary among pediatric physicians, study suggests
http://mnt.to/a/4gxG
Clinicians use the do-not-resuscitate (DNR) order not only as a guide for therapeutic decisions during a cardiopulmonary arrest but also as a surrogate for broader treatment directives, according to a study by Amy Sanderson M.
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** PSYCHOLOGY / PSYCHIATRY News **
Interesting and useful musings are associated with a happy mood
http://mnt.to/a/4gwL
Mind wandering can be a sign of mental wellbeing, provided that your off-task musings are interesting and useful even if not related to the task at hand, finds a new study in Frontiers in Psychology.
A history of depression increases risk for future episodes following divorce
http://mnt.to/a/4gwH
Divorce is associated with an increased risk of future depressive episodes but only for those who already have a history of depression, according to a new study published in Clinical Psychological Science, a journal of the Association for Psychological Science.
Cannabis and the adolescent brain: Perception as a 'safe drug' is scientifically inaccurate
http://mnt.to/a/4gw5
The nature of the teenage brain makes users of cannabis amongst this population particularly at risk of developing addictive behaviors and suffering other long-term negative effects, according to researchers at the University of Montreal and New York's Icahn School of Medicine at Mount Sinai.
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** PUBLIC HEALTH News **
Excessive screen time affects children's well-being
http://mnt.to/a/4gxP
A sedentary lifestyle with too much time spent sitting in front of screens - such as watching TV, playing video games and surfing the Internet - is harming children's well-being and increasing their anxiety, according to a new briefing paper from Public Health England (PHE).
New treatments better than standard ones just over half the time
http://mnt.to/a/4gx3
USF Distinguished Professor Benjamin Djulbegovic, MD, PhD, has studied the ethics of randomized clinical trials and their effectiveness in evaluating the outcomes of new treatments for decades.
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** SLEEP / SLEEP DISORDERS / INSOMNIA News **
Non-invasive transcranial direct current stimulation improves sleep in patients with post-polio syndrome
http://mnt.to/a/4gwd
Of the 15 million people around the world who have survived poliomyelitis, up to 80% report progressive deteriorating strength and endurance many years after infection, a condition known as post-polio syndrome (PPS).
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** STEM CELL RESEARCH News **
Scientists successfully grow 'mini-brains' from stem cells
http://mnt.to/a/4gxB
Scientists have successfully grown complex human brain tissue from stem cells using a new 3D culture system, according to a study published in the journal Nature.Researchers from the Institute of Molecular Biotechnology (IMBA) at the Austrian Academy of Sciences (OeAW) say the newly created tissue could be the start of developing model systems for the human brain.
Some stem cells are more susceptible to cancer than others
http://mnt.to/a/4gx6
Cells in the body wear down over time and die. In many organs, like the small intestine, adult stem cells play a vital role in maintaining function by replacing old cells with new ones. Learning about the nature of tissue stem cells can help scientists understand exactly how our organs are built, and why some organs generate cancer frequently, but others only rarely.
Novel treatment for stroke and possibly other neurological diseases
http://mnt.to/a/4gw7
In the latest in a series of experiments testing the use of stem cells to treat neurological disease, researchers at Henry Ford Hospital have shown for the first time that microscopic material in the cells offers a "robust" treatment for crippling stroke.
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** STROKE News **
Novel treatment for stroke and possibly other neurological diseases
http://mnt.to/a/4gw7
In the latest in a series of experiments testing the use of stem cells to treat neurological disease, researchers at Henry Ford Hospital have shown for the first time that microscopic material in the cells offers a "robust" treatment for crippling stroke.
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** TRANSPLANTS / ORGAN DONATIONS News **
Skin cancer an increased risk for recipients of donor kidneys
http://mnt.to/a/4gwF
Patients that receive kidney transplants have an increased risk of an invasive form of skin cancer. It is unclear if donor tissue contributes to cancer formation. In this issue of the Journal of Clinical Investigation, Philippe Ratajczak and colleagues at INSERM demonstrate that donor tissue can lead to cancer formation in transplant recipients.
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** UROLOGY / NEPHROLOGY News **
Kidney stone removal breakthrough combines robotic surgery with new cooling technique
http://mnt.to/a/4gwN
A first-ever technique using ice slush and minimally invasive robotic surgery to remove a particularly large type of kidney stone has been reported by urologists at Henry Ford Hospital.Dubbed RANL, for robotic anatrophic nephrolithotomy, the technique was devised to remove staghorn calculi - large kidney stones with sharp, craggy branches - that can cause disease and sometimes death if left untreated.
Skin cancer an increased risk for recipients of donor kidneys
http://mnt.to/a/4gwF
Patients that receive kidney transplants have an increased risk of an invasive form of skin cancer. It is unclear if donor tissue contributes to cancer formation. In this issue of the Journal of Clinical Investigation, Philippe Ratajczak and colleagues at INSERM demonstrate that donor tissue can lead to cancer formation in transplant recipients.
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** WOMEN'S HEALTH / GYNECOLOGY News **
Math anxiety experienced by girls
http://mnt.to/a/4gwK
Girls report more math anxiety on general survey measures but are not actually more anxious during math classes and exams, according to new research forthcoming in Psychological Science, a journal of the Association for Psychological Science.
Gynecologic surgery patients benefit from enhanced recovery pathway
http://mnt.to/a/4gw9
Patients who had complex gynecologic surgery managed by an enhanced recovery pathway (ERP) resulted in decreased narcotic use, earlier discharge, stable readmission rates, excellent patient satisfaction and cost savings, according to a Mayo Clinic study.
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