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'Cutting Up Molecules' Enables Ultrafast Complex Molecular Simulations

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Two Japanese professors enable rapid simulations of molecules through their research. Professor Stephan Irle and Yoshio Nishimoto at the Institute of Transformative Bio-Molecules (ITbM) of Nagoya University and Dr. Dmitri Fedorov of the National Institute of Advanced Industrial Science and Technology (AIST, Tsukuba) have developed a novel ultrafast quantum chemical method enabling rapid simulations of molecules containing more than a million atoms without detrimental loss in ...

How Good is Your Grip Strength?

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Throwing new light on grip strength, Researchers from the Medical Research Council Lifecourse Epidemiology Unit (MRC LEU), University of Southampton have studied how strength changes across lifespan. Previous work has shown that people with weaker grip strength in midlife and early old age are more likely to develop problems, such as loss of independence and to have shorter life expectancy. However, there is little information on what might be considered a normal grip strength ...

OPP Database Should be Given Time to Improve

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A 'Viewpoint' published in JAMA urges readers to be patient with the new federal Open Payments Program (OPP) database. The site has been designed to report drug and device industry payments to physicians. When the database produced by the Centers for Medicare and Medicaid Services went online on Sept. 30 it was found to be substantially incomplete. OPP would be most useful to patients if its data were available within other sites that report other indicators ...

Hypertension Leads to Poor Semen Quality in Men, Study Reveals

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A recent study among 9,000 men reveals that male fertility problems have a correlation between the number of different defects in male semen and other health problems in his body. The study, conducted by investigators at the Stanford University School of Medicine, also links poor semen quality to a higher chance of having various specific health conditions, such as hypertension, and more generally to skin and endocrine disorders. The findings, to be ...

Warm Water Rising from Below Threatens Antarctic Ice Sheets

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A team of scientists has observed rising temperatures on the West Antarctic shelf. The Antarctic ice sheet is a giant water reservoir. The ice cap on the southern continent is on average 2,100 meters thick and contains about 70 percent of the world's fresh water and if this ice mass were to melt completely, it could raise the global sea level by 60 meters. Lead author Sunke Schmidtko said that there are many large glaciers in the area and the elevated ...

Chemical Modifications On RNA Determine Embryonic Stem Cell Ability

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Researchers have recently discovered a novel mechanism of RNA regulation in embryonic stem cells. The findings are strong evidence that a specific chemical modification, or "tag," on RNA plays a key role in determining the ability of embryonic stem cells to adopt different cellular identities. The team also included scientists from Harvard Medical School, Massachusetts General Hospital and Stanford University. Published in the journal iCell Stem Cell/i, ...

Ranbp9 Gene Important for Male Fertility

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Ranbp9, the gene expressed in testis, plays a major role in male fertility by controlling the correct expression of thousands of genes required for successful sperm production. A group of researchers led by Professor Wei Yan, at the University of Nevada School of Medicine has discovered that a loss of function of Ranbp9 leads to severely reduced male fertility due to disruptions in sperm development. A paper reporting this finding was published in iPLOS Genetics/i on December ...

Human Immune System - Similar to the Weather, Ask Scientists

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Recently scientists have looked into studying whether the human immune system is similar to the weather and if it can be modeled based on past conditions to predict future states. Scientists at VCU Massey Cancer Center's award-winning Bone Marrow Transplant (BMT) Program believe it is, and they recently published several studies that support the possibility of using next-generation DNA sequencing and mathematical modeling to not only understand the variability observed in clinical ...

BGRF to Present Research on Longevity Expectations in the Pension Fund, Insurance, Employee Benefits Industry

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The Biogerontology Research Foundation (BGRF) will present new economic longevity research 'longevity expectations in the pension fund, insurance, and employee benefits industry' at the second Big Data Science in Medicine (BDSM) congress in Oxford on December 8. BGRF a UK-based charity was founded to support ageing research and address the challenges of a rapidly ageing population. Alex Zhavoronkov, Director of the BGRF and CEO of InSilico Medicine said, "The progress ...

Altered Thyroid Levels During Pregnancy Can Impact Fetal Brain Development

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Endocrine disrupting chemicals like polychlorinated biphenyls (PCB) can interfere with thyroid hormone action in pregnant women and may travel across the placenta to affect the fetus. The polychlorinated biphenyls (PCB) are found in flame retardant cloth, paint, adhesives and electrical transformers. This new study was led by biologist R. Thomas Zoeller of the University of Massachusetts Amherst. Results appeared in an early online edition and in the December print ...

No Delay in Referral and Treatment When Using Teleophthalmology

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Research has revealed that there was no delay between referral and treatment when teleophthalmology was used for screening suspected age-related macular degeneration (AMD). While teleophthalmology monitoring for recurrence of AMD did result in an average longer wait time for treatment reinitiation, it did not result in worse visual outcomes, according to a study published online by JAMA Ophthalmology. AMD is a common cause of visual impairment in older adults. ...

Broccoli Pill can Fight Cancer

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A pill that can fight cancer has been developed from broccoli by scientists of drug company Evgen. The pill acts by slowing the cancer growth and halting its spread. Sulforaphane, a naturally occurring but highly unstable compound found in broccoli and other vegetables of the brassica family, including brussels sprouts, cauliflower and cabbage has anti-cancer and neuroprotective properties. Eygen has a patent for the drug. A stabilized version of ...

Treatment Outcomes for TB Patients Predicted by Imaging Techniques

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Positron emission tomography (PET) and computed tomography (CT) are two medical imaging techniques can be reliably used together as a biomarker to help predict the effectiveness of antibiotic drug regimens. This is being tested to treat tuberculosis (TB) patients, according to researchers at the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health. With multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis ...

Why are Crows Left or Right Beaked When Wielding Tools?

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Known for their impressive stick-wielding abilities, New Caledonian crows show preferences when it comes to holding their tools on the right or the left sides of their beaks, in much the same way that people are left or right-handed. Now researchers reporting in the Cell Press journal emCurrent Biology/em on December 4 suggest that those bill preferences allow each bird to keep the tip of its tool in view of the eye on the opposite side of its head. Crows aren't so much left- ...

High-data Rate Wireless Brain Sensor a Breakthrough in Neuroscience

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Scientists have described a new high data-rate, low-power wireless brain sensor, in a study in journal iNeuron/i. The technology is designed to enable neuroscience research that cannot be accomplished with current sensors that tether subjects with cabled connections. Experiments in the paper confirm that new capability. The results show that the technology transmitted rich, neuroscientifically meaningful signals from animal models as they slept and woke or exercised. ...

Coordinating Care of Seniors Moving Across Treatment Still Remains a Problem

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A team led by a Johns Hopkins geriatrician has further documented hindrances to better care of older adults as they are transferred from hospital to rehabilitation center to home, and too often back again. This is believed to be the first interview-style qualitative study of its kind among health care providers in the trenches Using comments and concerns drawn from in-depth interviews of 18 physicians and two home health care agency administrators - all ...

German Hospital Cures Ugandan Doctor for Ebola

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After seven weeks of intensive treatment, a Ugandan doctor who contracted Ebola in Sierra Leone has been released from a German hospital, the clinic in Frankfurt said Thursday. The employee of an Italian charity had been hospitalised on October 3 in an isolation unit of the infectious disease center at Frankfurt University Hospital and was released on November 19. He had suffered "critical multi-organ failure" and required intensive medical therapy including ...

Taser-like Shocks in Electric Eels Help in Striking Prey Easily

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By overwhelming the nerves that control the muscles in the target's body, the Taser works. This causes the muscles to involuntarily contract. To determine if the eel's electrical discharge had the same effect, Catania walled off part of the aquarium with an electrically permeable barrier. He placed a pithed fish on other side of the barrier from the eel and then fed the eel some earthworms, which triggered its electrical volleys. The volleys that passed through the ...

Female Sex Hormones can Prevent Blood Disorders

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The path-breaking discovery that Female sex hormones can protect against the development of some blood disorders brings a sigh of relief to large number of people. Currently, there is no cure of most blood disorders. The study was led by Dr. Simon Mendez-Ferrer of the CNIC, working in partnership with the laboratories of Doctors Jurg Schwaller and Radek Skoda of the University Hospital in Basel (Switzerland). The study's authors have demonstrated in mice that tamoxifen, ...

Rice is More Effective Than Glucose in Treating Cholera

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Bacterium iVibrio cholerae/i infects small intestine and causes cholera. Severe diarrhea and vomiting can result in dehydration and even death. The main treatment involves oral rehydration therapy, where the patient drinks water mixed with salts and glucose. But although proven to be enormously effective, there are concerns that the glucose content might actually worsen the disease. EPFL scientists have now shown that this is indeed the case, as glucose increases ...

Health Officials Call for Flu Preparedness

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US health authorities warned on Thursday that flu season could be especially severe this year. They also added that, due to genetic mutations, vaccine won't be as effective against some of the most prevalent flu strains. So far this season, most flu patients in the United States have contracted seasonal influenza A H3N2 viruses. This group of viruses was also the most common in the three deadliest flu seasons over the past decade, said officials at the ...

New Smart Clothes can Help Keep a Tab on Health

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Smart clothes that can monitor and transmit your biomedical information through wireless or cellular networks have been developed by scientists. The technological breakthrough by researchers at Universite Laval, clears a path for a host of new developments for people suffering from chronic diseases, elderly people living alone, and even firemen and police officers. A team under the supervision of Professor Younes Messaddeq created the smart fabric by ...

How Grip Strength Changes As We Age

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A new research has shed light on how grip strength changes across life. Previous work has shown that people with weaker grip strength in midlife and early old age are more likely to develop problems, such as loss of independence and to have shorter life expectancy. However, there is little information on what might be considered "normal" grip strength at different ages. This research from the Medical Research Council Lifecourse Epidemiology ...

Focus on Hot Zones to Stop Spread of HIV: UCLA Study

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The sub-Saharan Africa and rest of the world has been recently affected adversely by a recent HIV epidemic. Globally, more than 34 million people are infected with HIV; in sub-Saharan Africa alone, 3 million new infections occur annually. In an attempt to stop the spread of HIV, governments in the region are considering providing antiretroviral drugs to people who do not have the virus but are at risk for becoming infected. Such drugs are known as pre-exposure prophylaxis, ...

Quiz on Perimenopause

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Perimenopause stage is when a woman undergoes the transition from her fertility period of life to menopause. Test your knowledge on perimenopause by taking this quiz.

Going Needle-less: Pediatric Pain Treatable With Intranasal Ketamine, Say Doctors

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Children in emergency departments can now be treated using intranasal ketamine for limb injuries. This drug is more typically used for sedation, according to the results of the first randomized, controlled trial comparing intranasal analgesics in children in the emergency department. The study was published online last month in 'Annals of Emergency Medicine' ("The PICHFORK (Pain in Children Fentanyl OR Ketamine) Trial: A Randomized Controlled Trial Comparing Intranasal Ketamine ...

Pack your School Bag the Right Way - Slide Show

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Carrying heavy school bags is one of the major causes of back pain in children. Mild to severe back pain, mid back pain, neck pain and stiff back are some of the complaints.

Study Shows Encapsulation of Cancer Drugs Reduces Heart Damage

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A study, presented at EuroEcho-Imaging 2014 by Professor Jutta Bergler-Klein and Professor Mariann Gyongyosi from the Medical University of Vienna, Austria, has shown that a new technique which wraps chemotherapy drugs in a fatty cover (called a liposome) reduces heart damage. EuroEcho-Imaging is the annual meeting of the European Association of Cardiovascular Imaging (EACVI), a branch of the European Society of Cardiology (ESC), and is held 3-6 December in Vienna. ...

At Least 11 Indians Lose Eyesight After Undergoing Cataract Surgery

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At least 11 people have lost their sight after undergoing free cataract surgery in northern India, government authorities say, as fears grow the final figure will be far higher. Officials said 62 people had the surgery at a village camp run by a medical charity on November 4, and they were trying to ascertain how many people had lost their sight. "For now, there are 11 confirmed cases of patients from the camp who have lost their eyesight," said Abhinav ...

Friendly Gut Bacteria Help Fight Malaria

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A new study has revealed that specific bacterial components in the human gut microbiota can trigger a natural defense mechanism that is highly protective against malaria transmission. Bahtiyar Yilmaz, a PhD student of the Instituto Gulbenkian de Ciencia PhD programme in Miguel Soares' laboratory, found that the Plasmodium parasite, the causative agent of malaria, expresses a sugar molecule called alpha-gal, which is also expressed at the surface of a strain of E. ...

Important Facts of Ebola

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Ebola or Ebola hemorrhagic fever is a rare and fatal disease. Humans and nonhuman primates can be affected by the virus. Infection with virus belonging to Filoviridae family causes Ebola disease.

Breast Cancer Drug Approval is Offering Hope for Treatment

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The number of male blood cancer patients clearly out-numbers that of females. However, it is not yet clear why this is the case. A study published by Cell Press December 4th in iCell Stem Cell/i provides an explanation, revealing that female sex hormones called estrogens regulate the survival, proliferation, and self-renewal of stem cells that give rise to blood cancers. Moreover, findings in mice with blood neoplasms - the excessive production of certain blood cells - ...

Obesity Clips Up To 8 Years Off Your Life

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Obesity and extreme obesity can reduce life expectancy by up to eight years and deprive people of as much as 19 years of good health, a new study has found. The research - a mathematical model based on US health data - should be a useful tool for doctors advising patients who are worryingly overweight, its authors said. The biggest area of concern is for people who become obese while they are young. "The pattern is clear," said Steven Grover, ...

Specific Bacteria in Microbiota Helps Protect from Malaria

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In a recent breakthrough research led by Miguel Soares, it was discovered that specific bacterial components in microbiota (human gut) can generate a natural defense mechanism to protect from malaria transmission. Over the past few years, the scientific community became aware that humans live under a continuous symbiotic relationship with a vast community of bacteria and other microbes that reside in the gut. These microbes, know as the gut microbiota, do not necessarily ...

Hypertension is Related to Obesity

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Over the years, it has been found that cardiovascular diseases are related to obesity. Obesity does lead to blood pressure and cardiovascular diseases and being overweight is a major risk factor. But, it has not been known how obesity increases the risk of high blood pressure, making it difficult to develop evidence based therapies for obesity, hypertension and heart disease. In a ground-breaking study, published today in the prestigious journal, 'Cell', researchers ...